Inhibitors of thymine nucleotide biosynthesis: Antimetabolites that provoke genetic change via primary non-DNA targets

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 355, Issue 1-2, 1996, Pages 129-140

  Kunz, Bernard A ^a  

^a DEAKIN UNIVERSITY   (Australia)

Author keywords

antifolate; deoxyribonucleotide pool; genetic instability; thymidylate synthase inhibitor

Indexed keywords

AMINOPTERIN; ANTIMETABOLITE; ENZYME INHIBITOR; FLOXURIDINE; FLUOROURACIL; FOLIC ACID ANTAGONIST; METHOTREXATE; METODICLOROFEN; PYRIMETHAMINE; SULFACETAMIDE; SULFANILAMIDE; SULFATHIAZOLE; SULFONAMIDE; TRIMETHOPRIM;

ANIMAL CELL; ANIMAL EXPERIMENT; GENETIC STABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALIA;

EID: 0030591659     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00026-7     Document Type: Article

References (134)

1. Aebersold, P.M. (1979) Mutation induction by 5-fluorodeoxyuridine in synchronous Chinese hamster cells, Cancer Res., 39, 808-810.
2. Ayusawa, D., H. Araki, Y. Wataya and T. Seno (1988) A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells, Mutation Res., 200, 221-230.
3. Bachmann, B., R. Hofmann and H. Follmann (1983) Tight coordination of ribonucleotide reduction and thymidylate synthesis in synchronous algae, FEBS Letts., 152, 247-250.
4. Badr, A. (1972) Cytogenetic activities of 3 sulphonamides, Mutation Res., 104, 95-100.
5. Banerjee, A. and W.F. Benedict (1979) Production of sister chromatid exchanges by various cancer chemotherapeutic agents, Cancer Res., 39, 797-799.
6. Barclay, B.J., B.A. Kunz, J.G. Little and R.H. Haynes (1982) Genetic and biochemical consequences of thymidylate stress, Can. J. Biochem., 60, 172-194.
7. Bazin, C., J. Silber and J.M. Goux (1983) Etude de l'action de l'aminopterine sur la recombinaison génétique chez Drosophila melanogaster, Genetica, 60, 119-122.
8. Bebenek, K. and T.A. Kunkel (1990) Frameshift errors initiated by nucleotide misincorporation, Proc. Natl. Acad. Sci. USA, 87, 4946-4950.
9. 1)C1-3 cells by cancer chemotherapeutic agents, Cancer Res., 37, 2202-2208.
10. Berger, H. (1965) Genetic analysis of T4D phage heterozygotes produced in the presence of 5-fluorodeoxyuridine, Genetics, 52, 724-756.
11. Berry, R.J. (1965) A reduced oxygen enhancement ratio for X-ray survival of HeLa cells in vitro, after treatment with 'Methotrexate', Nature (Lond.), 208, 1108-1110.
12. Bestwick, R.K., G.L. Moffett and C.K. Mathews (1982) Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite treated HeLa cells, J. Biol. Chem., 257, 9300-9304.
13. Bignami, M., G. Morpurgo, R. Pagliani, A. Carere, G. Conti and G. Di Giuseppe (1974) Non-disjunction and crossing-over induced by pharmaceutical drugs in Aspergillus nidulans, Mutation Res., 26, 159-170.
14. Biswas, S.B. and A. Kornberg (1984) Nucleoside triphosphate binding to DNA polymerase III holoenzyme of Escherichia coli, J. Biol. Chem., 259, 7990-7993.
15. Borchers, A.H. and J.A. Straw (1990) Characterization of repair inhibition by methotrexate of ethylmethanesulfonate and ultraviolet irradiation-induced DNA damage in Chinese hamster cells, Biochem. Pharmacol., 40, 1925-1928.
16. Borchers, A.H., K.A. Kennedy and J.A. Straw (1990) Inhibition of DNA excision repair by methotrexate in Chinese hamster ovary cells following exposure to ultraviolet irradiation or ethylmethanesulfonate, Cancer Res., 50, 1786-1789.
17. Bottura, C. and V. Coutinho (1965) The effect of pyrimethamine on the human chromosomes, Rev. Brasil. Biol., 25, 145-147.
18. Branda, R.F. and D.B. Blickensderfer (1993) Folate deficiency increases genetic damage caused by alkylating agents and γ-irradiation in Chinese hamster ovary cells, Cancer Res., 53, 5401-5408.
19. Bresler, S., M. Mosevitsky and L.G. Vyacheslavov (1973) Mutations as possible replication errors in bacteria growing under conditions of thymine deficiency, Mutation Res., 19, 281-293.
20. Brookwell, R., A. Daniel, G. Turner and J. Fishburn (1982) The fragile X(q27) form of X-linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts and amniocytes, Am. J. Med. Genet., 13, 139-148.
21. Bruce, W.R. and J.A. Meddle (1979) The mutagenic activity of 61 agents determined by the micronucleus, Salmonella, and sperm abnormality assays, Can. J. Genet. Cytol., 21, 319-334.
22. Caradonna, S.J. and Y.-C. Cheng (1980) The role of deoxyuridine triphosphate nucleotidhydrolase, uracil-DNA glycosylase, and DNA polymerase α in the metabolism of FUdR in human tumor cells, Mol. Pharmacol., 18, 513-520.
23. Clements, J., D. Howe and D. Quinn (1990) The genetic effects of the anti-cancer drug methotrexate in somatic and germline cells of Drosophila, Mutation Res., 234, 75 (Abstr.).
24. Cohen, S.S., J.G. Flaks, H.D. Barner, M.R. Loeb and J. Lichtenstein (1958) The mode of action of 5-fluorouracil and its derivatives, Proc. Natl. Acad. Sci. USA, 44, 1004-1012.
25. Cox, E.C. and D.L. Horner (1986) DNA sequence and coding properties of mutD (dnaQ) a dominant Escherichia coli mutator gene, J. Mol. Biol., 190, 113-117.
26. Davies, R. and D. Wimber (1964) cited in Bell, S. and S. Wolff (1964) Studies on the mechanism of the effect of fluorodeoxyuridine on chromosomes, Proc. Natl. Acad. Sci. USA, 51, 195-202.
27. de Serres, F.J. (Ed.) (1985) Genetic Consequences of Nucleotide Pool Imbalance, Plenum Press. New York.
28. Drake, J.W. and E.O. Greening (1970) Suppression of chemical mutagenesis in bacteriophage T4 by genetically modified DNA polymerases, Proc. Natl. Acad. Sci. USA, 66, 823-829.
29. Fogel, M. (1972) Induction of virus synthesis in polyoma-transformed cells by DNA antimetabolites and by irradiation after pretreatment with 5-bromodeoxyuridine, Virol., 49, 12-22.
30. Gadsden, M.H., E.M. McIntosh, J.C. Game, P.J. Wilson and R.H. Haynes (1993) dUTP pyrophosphatase is an essential enzyme in Saccbaromyces cerevisiae, EMBO J., 12, 4425-4431.
31. Galloway, S.M. (1977) Ataxia telangiectasia: The effects of chemical mutagens and X-rays on sister chromatid exchanges in blood lymphocytes, Mutation Res., 45, 343-349.
32. Genther, C.S., R.S. Schoeny, J.C. Loper and C.C. Smith (1977) Mutagenic studies of folic acid antagonists, Antimicrob. Agents Chemother., 12, 84-92.
33. Glover, T.W. (1981) FUdR induction of the X chromosome fragile site: Evidence for the mechanism of folic acid and thymidine inhibition, Am. J. Hum. Genet., 33, 234-242.
34. Goulian, M., B. Bliele and B.Y. Tseng (1980) Methotrexate-induced misincorporation of uracil into DNA, Proc. Natl. Acad. Sci. USA, 77, 1956-1960.
35. Griffiths, A.J.F. (1979) Neurospora prototroph selection system for studying aneuploid production, Environ. Health Perspect., 31, 75-80.
36. Gröbner, P. and P. Loidl (1982) Action of 5′-fluorodeoxyuridine on synchronous nuclear division and thymidylate synthetase activity of Physarum polycephalum, FEBS Lett., 140, 41-44.
37. Hansmann, I. (1974) Chromosome aberrations in metaphase II-oocytes, stage sensitivity in the mouse oogenesis to amethopterin and cyclophosphamide, Mutation Res., 22. 175-191.
38. Haynes, R.H. and B.A. Kunz (1986) The influence of thymine nucleotide depletion on genetic stability and change in eukaryotic cells, Curr. Sci., 55, 1-11.
39. Haynes, R.H., F. Eckardt and B.A. Kunz (1984) The DNA damage-repair hypothesis in radiation biology: comparisons with classical hit theory, Br. J. Cancer, Suppl. VI, 81-90.
40. Henderson, J.F., F.W. Scott and J.K. Lowe (1980) Toxicity of naturally occurring purine deoxyribonucleosides, Pharmacol. Ther., 8, 573-604.
41. Hoar, D.I. and L.S. Dimnik (1985) Induction of mitochondrial mutations in human cells by methotrexate, in: F.J. de Serres (Ed.), Genetic Consequences of Nucleotide Pool Imbalance, Plenum Press, New York, pp. 265-282.
42. Hsu, T.C., R.M. Humphrey and C.E. Somers (1964) Response of Chinese hamster and L cells to 2′-deoxy-5-fluorouridine and thymidine, J. Natl. Cancer Inst., 32, 839-855.
43. Ingraham, H.A., B.Y. Tseng and M. Goulian (1980) Mechanism for exclusion of 5-fluorouracil from DNA, Cancer Res., 40, 998-1001.
44. Ingraham, H.A., B.Y. Tseng and M. Goulian (1982) Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine, Mol. Pharmacol., 21, 211-216.
45. Jacky, P.B. and G.R. Sutherland (1983) Thymidylate synthetase inhibitors and fragile site expression in lymphocytes, Am. J. Hum. Genet., 35, 1276-1283.
46. 1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides, Cancer Res., 36, 101-107.
47. Jones, S., E. Willmore and B.W. Durkacz (1994) The effects of fluropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elution, Carcinogenesis, 15, 2435-2438.
48. Kefford, R.F., and R.M. Fox (1982) Deoxycoformycin-induced response in chronic lymphocytic leukaemia: Deoxyadenosine toxicity in non-replicating lymphocytes, Br. J. Haematol., 50, 627-636.
49. Kihlman, B.A. (1962) The production of chromatid aberrations by 5-fluorodeoxyuridine alone and in combination with X-rays and 8-ethoxycaffeine, Caryologia, 15, 261-277.
50. Kozinski, A.W. and P.B. Kozinski (1964) Replicative fragmentation in T4 bacteriophage in DNA II. Biparental molecular recombination, Proc. Natl. Acad. Sci. USA, 52, 211-218.
51. Kremer, E.J., M. Pritchard, M. Lynch, S. Yu, K. Holman, E. Baker, S.T. Warren, D. Schlessinger, G.R. Sutherland and P.I. Richards (1991) Mapping of a DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n, Science, 252, 1711-1714.
52. Krogh Jensen, M. and A. Nyfors (1979) Cytogenetic effect of methotrexate on human cells in vivo, comparison between results obtained by chromosome studies on bone-marrow cells and blood lymphocytes and by the micronucleus test, Mutation Res., 64, 339-343.
53. Krumdieck, C.L. (1983) Role of folate deficiency in carcinogenesis, in: C.E. Butterworth and M.L. Hutchinson (Eds.), Nutritional Factors in the Induction and Maintenance of Malignancy, Academic Press, New York, pp. 225-245.
54. Kunkel, T.A. (1988) Exonucleolytic proofreading, Cell, 53, 837-840.
55. Kunz, B.A. (1982) Genetic effects of deoxyribonucleotide pool imbalances, Environ. Mutagenesis, 4, 695-725.
56. Kunz, B.A. (1988) Mutagenesis and deoxyribonucleotide pool imbalance, Mutation Res., 200, 133-147.
57. Kunz, B.A. and R.H. Haynes (1981) Phenomenology and genetic control of mitotic recombination in yeast, Annu. Rev. Genet., 15, 57-89.
58. Kunz, B.A. and R.H. Haynes (1982) DNA repair and the genetic effects of thymidylate stress in yeast, Mutation Res., 93, 353-375.
59. Kunz, B.A. and S.E. Kohalmi (1991) Modulation of mutagenesis by deoxyribonucleotide levels, Ann. Rev. Genet., 25, 339-359.
60. Kunz, B.A., B.J. Barclay, J.C. Game, J.G. Little and R.H. Haynes (1980) Induction of mitotic recombination in yeast by starvation for thymine nucleotides, Proc. Natl. Acad. Sci. USA, 77, 6057-6061.
61. Kunz, B.A., G.R. Taylor B. Konforti, B.W. Glickman and R.H. Haynes (1984) Inhibition of thymidylate biosynthesis induces mitotic unequal sister chromatid recombination in Saccharomyces cerevisiae, Curr. Genet., 8, 211-217.
62. Kunz, B.A., G.R. Taylor and R.H. Haynes (1985) Mating-type switching in yeast is induced by thymine nucleotide depletion, Mol. Gen. Genet., 199, 540-542.
63. Kunz, B.A., G.R. Taylor and R.H. Haynes (1986) Induction of intrachromosomal recombination in yeast by inhibition of thymidylate biosynthesis, Genetics, 114, 375-392.
64. Kunz, B.A, S.E. Kohalmi, T.A. Kunkel, C.K. Mathews, E.M. McIntosh and J.A. Reidy (1994) Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability, Mutation Res., 318, 1-64.
65. Kyprianou, N. and J.T. Issacs (1989) "Thymineless" death in androgen-independent prostatic cancer cells, Biochem. Biophys. Res. Commun., 165, 73-81.
66. Laird, C., E. Jaffe, G. Karpen, M. Lamb and R. Nelson (1987) Fragile sites in human chromosomes as regions of late-replicating DNA, Trends Genet., 3, 274-281.
67. Little, J.W. (1976) The effect of bromouracil on recombination in phage lambda, Virology, 72, 530-535.
68. Luchnik, N.V., E.V. Fesenko and V.G. Ovchinnikova (1976) Critical periods of the mitotic cycle: Influence of aminopterin and thymidine on production of chromosomal aberrations by radiation in Crepis capillaris, Mutation Res., 34, 367-388.
69. MacPhee, D.G., R.H. Haynes, B.A. Kunz and D. Anderson (Eds.) (1988) Genetic aspects of deoxyribonucleotide metabolism, Mutation Res., 200.
70. Maier, P. and W. Schmid (1976) Ten model mutagens evaluated by the micronucleus test, Mutation Res., 40, 325-338.
71. Markkanen, A., K. Heinonen, S. Knuutila and A. de la Chapelle (1982) Methotrexate-induced increase in gap formation in human chromosome band 3p14, Heriditas, 96, 317-319.
72. Matheson, D.S., B.J. Green, D.I. Hoar, S.J. Friedman and M. Inoue (1985) Agents which decrease thymidine pools cause an augmentation in human natural killer activity in vitro, in: F.J. de Serres (Ed.), Genetic Consequences of Nucleotide Pool Imbalance, Plenum Press, New York, pp. 461-464.
73. Mathews, C.K. (1989) Enzymes of DNA precursor synthesis and the control of DNA replication, in: K.W. Adolph (Ed.), Molecular Biology of Chromosome Function, Springer-Verlag, New York, pp. 461-470.
74. Maybaum, J., M.B. Cohen and W. Sadee (1981) In vivo rates of pyrimidine nucleotide metabolism in intact mouse T-lymphoma (S-49) cells treated with 5-fluorouracil, J. Biol. Chem., 256, 2126-2130.
75. McIntosh, E.M. and R.H. Haynes (1984) Isolation of a Saccharomyces cerevsiiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme, J. Bacteriol., 158, 644-649.
76. Melnyk, J., D.M. Duffy and R.S. Sparkes (1971) Human mitotic and meiotic chromosome damage following in vivo exposure to methotrexate, Clin. Genet., 11, 28-31.
77. Meuth, M. (1984) The genetic consequences of nucleotide precursor pool imbalance in mammalian cells, Mutation Res., 126, 107-112.
78. Meuth, M. (1989) The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells, Exp. Cell Res., 181, 305-316.
79. Meyer, J.R. (1948) Modification of mitosis by chemicals, Science, 108, 188.
80. Modrich, P. (1991) Mechanisms and biological effects of mismatch repair, Annu. Rev. Genet., 25, 229-253.
81. Mondello, C., R. Giorgi and F. Nuzzo (1984) Chromosomal effects of methotrexate on cultured human lymphocytes, Mutation Res., 139, 67-70.
82. Mukhopadhyay, P. and S. Palchaudhuri (1982) Trimethoprim-produced F-specific insertion mutations in Escherichia coli K-12, J. Bacteriol., 150, 755-761.
83. Neuhard, J. (1966) Studies on the acid-soluble nucleotide pool in thymine-requiring mutants of Escherichia coli during thymine starvation. III. On the regulation of the deoxyadenosine triphosphate and deoxycytidine triphosphate pools of Escherichia coli, Biochim. Biophys. Acta, 129, 104-115.
84. Norin, A.J. and E.P. Goldschmidt (1979) Effect of mutagens, chemotherapeutic agents and defects in DNA repair genes on recombination in F' partial diploid Escherichia coli, Mutation Res., 59, 15-26.
85. Nussbaum, R.L. and D.H. Ledbetter (1986) Fragile X syndrome: A unique mutation in man, Annu. Rev. Genet., 20, 109-145.
86. Ockey, C.H., T.C. Hsu and L.C. Richardson (1968) Chromosome damage induced by 5-fluoro-2′-deoxyuridine in relation to the cell cycle of the Chinese hamster, J. Natl. Cancer Inst., 40, 465-475.
87. O'Donovan, G.A., G. Edlin, J.A. Fuchs, J. Neuhard and E. Thomassen (1971) Deoxycytidine triphosphate deaminase: Characterization of an Escherichia coli mutant deficient in the enzyme, J. Bacteriol., 105, 666-672.
88. O'Dwyer, P.J., S.A. King, D.F. Hoth and B. Leyland-Jones (1987) Role of thymidine in biochemical modulation: A review, Cancer Res., 47, 3911-3919.
89. Ohta, T., M. Watanabe, R. Tsukamoto, Y. Shirasu and T. Kada (1986) Antimutagenic effects of 5-fluorouracil and 5-fluorodeoxyuridine on UV-induced mutagenesis in Escherichia coli, Mutation Res., 173, 19-24.
90. Pardo, E.G., P. Hernandez and C. Gutierrez (1987) The incorporation of deoxyuridine monophosphate into DNA increases the sister-chromatid exchange yield, Exp. Cell Res., 168, 507-517.
91. Parry, J.M. (1977) The detection of chromosome non-disjunction in the yeast Saccharomyces cerevisiae, in: D. Scott, B.A. Bridges and F.H. Sobels (Eds.), Progress in Genetic Toxicology, Elsevier/North Holland Biomedical Press, Amsterdam, pp. 223-229.
92. Perlman, D. and J.A. Huberman (1977) Asymmetric Okazaki synthesis during replication of simian virus 40 DNA in vivo, Cell, 12, 1029-1043.
93. Peterson, A.R., H. Peterson and P.V. Danenberg (1983) Induction of mutations by 5-fluorodeoxyuridine: A mechanism of self-potentiated drug resistance?, Biochem. Biophys. Res. Commun., 110, 573-577.
94. Peterson, A.R., P.V. Danenberg, L.L.V. Ibric and H. Peterson (1985) Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis, in: F.J. de Serres (Ed.), Genetic Consequences of Nucleotide Pool Imbalance, Plenum Press, New York, pp. 313-334.
95. Podgorski, G. and R.A. Deering (1984) Thymidine-requiring mutants of Dictyostelium discoideun, Mol. Cell. Biol., 4, 2784-2791.
96. Putrament, A. (1967) On the mechanism of mitotic recombination in Aspergillus nidulans I. Intragenic recombination and DNA replication, Mol. Gen. Genet., 100, 307-320.
97. Reichard, P. (1985) Ribonucleotide reductase and deoxyribonucleotide pools, in: F.J. de Serres (Ed.), Genetic Consequences of Nucleotide Pool Imbalance, Plenum Press, New York, pp. 33-46.
98. Reichard, P. (1988) Interactions between deoxyribonucleotide and DNA synthesis, Annu. Rev. Biochem., 57, 349-374.
99. Reidy, J.A. (1987) Folate-and deoxyuridine-sensitive chromatid breakage may result from DNA repair during G2, Mutation Res., 192, 217-219.
100. Reidy, J.A. (1988) Role of deoxyuridine incorporation and DNA repair in the expression of human chromosomal fragile sites, Mutation Res., 200, 215-220.
101. Reyland, M.E., I.R. Lehman and L.A. Loeb (1988) Specificity of proofreading by the 3′ → 5′ exonuclease of the DNA polymerase-primase of Drosophila melanogaster, J. Biol. Chem., 263, 6518-6524.
102. Richards, R.G., L.C. Sowers, J. Laszlo and W.D. Sedwick (1985) The occurrence and consequences of deoxyuridine in DNA, Adv. Enz. Reg., 22, 157-185.
103. Ritter, E.J., W.J. Scott, J.G. Wilson, B.G. Lampkin and J.E Neely (1980) Effect of 5-fluoro-2′-deoxyuridine on deoxyribonucleotide pools in vivo, J. Natl. Cancer. Inst., 65, 603-605.
104. Rodriguez Murcia, C. and J.J. Arroyo Nombela (1972) Cytological aberrations produced by methotrexate in mouse ascites tumours, Mutation Res., 14, 405-412.
105. Rogers, A.E., R. Akhtar and S.H. Zeisel (1990) Procarbazine carcinogenicity in methotrexate-treated or lipotrope-deficient male rats, Carcinogenesis, 11, 1491-1495.
106. Rueckert, R.R. and G.C. Mueller (1960) Studies of unbalanced growth in tissue culture I. Induction and consequences of thymidine deficiency, Cancer Res., 20, 1584-1591.
107. Ryan, T.J., M.M. Boddington and A.I. Spriggs (1965) Chromosomal abnormalities produced by folic acid antagonists, Br. J. Dermatol., 77, 541-555.
108. Sato, S., H. Takizawa and N. Inui (1993) Mouse strain differences in induction of micronuclei by base analogues and nucleosides, Mutation Res., 301, 45-49.
109. Sedwick, W.D., M. Kutler and O.E. Brown (1981) Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA: Inhibition of high molecular weight DNA synthesis in human lymphoblastoid cells, Proc. Natl. Acad. Sci. USA, 78, 917-921.
110. Sharma, C.B.S.R. (1971) Cytological effects of sulphanilamide on the root apices of Allium cepa, Ind. J. Biochem. Biophys., 8, 324-326.
111. Shklar, G., E. Cataldo and A.L. Fitzgerald (1966) The effect of methotrexate on chemical carcinogenesis of hamster buccal pouch, Cancer Res., 26, 2218-2224.
112. Sieber, S.M. and R.H. Adamson (1975) Toxicity of antineoplastic agents in man: Chromosomal aberrations, antifertility effects, congenital malformations and carcinogenic potential, Adv. Cancer. Res., 22, 57-155.
113. Silber, J., C. Bazin and A. Le Menn (1985) Inhibitors of thymidylate synthesis increase whereas thymidine decreases meiotic recombination in Drosophila melanogaster, Mol. Gen. Genet., 199, 53-54.
114. Smith, M.D., R.R. Green, L.S. Ripley and J.W. Drake (1973) Thymineless mutagenesis in bacteriophage T4, Genetics, 74, 393-403.
115. Sorensen, P.J. and M. Krogh Jensen (1981) Cytogenetic studies in patients treated with trimethoprim-sulfamethoxazole. Mutation Res., 89, 91-94.
116. Stone, A.B. and D. Wilkie (1974) Cellular and mitochondrial effects of folate antagonism by pyrimethamine in Saccharomyces cerevisiae, 83, 283-293.
117. Sutherland, G.R. (1979) Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture, Am. J. Hum. Genet., 31, 125-135.
118. Sutherland, G.R. (1985) The enigma of the fragile X chromosome, Trends Genet., 1, 108-112.
119. Sutherland, G.R. (1988) The rote of nucleotides in human fragile site expression, Mutation Res., 200, 207-213.
120. Tattersall, M.H.M. and K.R. Harrap (1973) Changes in the deoxribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil, Cancer Res., 33, 3086-3090.
121. Taylor, J.H., W.F. Haut and J. Tung (1962) Effects of fluorodeoxyuridine on DNA replication, chromosome breakage and reunion, Proc. Natl. Acad. Sci. USA, 48, 190-198.
122. Tommerup, N., H. Poulsen and K. Brondum-Nielsen (1981) 5-Fluoro-2′-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation, J. Med. Genet., 18, 374-376.
123. Traub, H.P. (1941) Effect of sulfanilamide and other sulfa-compounds, J. Hered., 32, 157-160.
124. Traut, H. (1978) The induction of X-chromosomal aneuploidy by 5-fluorodeoxyuridine (FUdR) fed to Drosophila melanogaster females, Can. J. Genet. Cytol., 20, 259-263.
125. Veigl, M.L., S. Schneiter, S. Mollis and W.D. Sedwick (1991) Specificities mediated by neighbouring nucleotides appear to underlie mutation induced by antifolates in E. coli, Mutation Res., 246, 75-91.
126. Verkerk, A.J.M.H., M. Pieretti, J.S. Sutcliffe, Y.-H. Fu, D.P.A. Kuhl, A. Pizzuti, O. Reiner, S. Richards, M.F. Victoria, F. Zhang, B.E. Eussen, G.-J.B. van Ommen, L.A.J. Blonden, G.J. Riggins, J.L. Chastain, C.B. Kunst, H. Galijaard, C.T. Caskey, D.L. Nelson, B.A. Oostra and S.L. Warren (1991) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in Fragile X Syndrome, Cell, 65, 905-914.
127. Voorhees, J.J., M.K. Janzen, E.R. Harrell and S.G. Chakrabarti (1969) Cytogenetic evaluation of methotrexate-treated psoriatic patients, Arch. Dermatol., 100, 269-274.
128. 12-deficient HL60 cells, Eur. J. Haematol., 50, 127-132.
129. Wintersberger, U. and J. Hirsch (1973a) Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate I. Studies on the mechanism of petite induction, Mol. Gen. Genet., 126, 61-70.
130. Wintersberger, U. and J. Hirsch (1973b) Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate II. Genetic analysis of the methotrexate-induced petites, Mol. Gen. Genet., 126, 71-74.
131. Würgler, F.E., U. Graf, H. Frei and H. Juon (1983) Genotoxic activity of the anti-cancer drug methotrexate in somatic cells of Drosophila melanogaster, Mutation Res., 122, 321-328.
132. Wurtz, E.A., J.E. Boynton and N.W. Gillham (1977) Perturbation of chloroplast DNA amounts and chloroplast gene transmission in Chlamydomonas reinhardtii by 5-fluorodeoxyuridine, Proc. Natl. Acad. Sci. USA, 74, 4552-4556.
133. Wurtz, E.A., B.B. Sears, D.K. Rabert, H.S. Shepherd, N.W. Gillham and J.E. Boynton (1979) A specific increase in chloroplast gene mutations following growth of Chlamydomonas in 5-fluorodeoxyuridine, Mol. Gen. Genet., 170, 235-242.
134. Yoshioka, A., S. Tanaka, O. Hiraoka, Y. Koyama, Y. Hirota, D. Ayusawa, T. Seno, C. Garrett and Y. Wataya (1987) Deoxyribonucleoside triphosphate imbalance: 5-fluorodeoxyuridine-induced DNA double-strand breaks in mouse FM3A cells and the mechanism of cell death, J. Biol. Chem., 262, 8235-8241.