Effects of hydroxymethylpropylcellulose (HPMC) moisture content on hydrochlorothiazide release from HPMC-based tablets

International Journal of Pharmaceutics

Volumn 135, Issue 1-2, 1996, Pages 147-149

  Mosquera, M J ^a   Cuna M ^a   Souto, C ^a   Concheiro, A ^a   Martinez Pacheco R ^a   Gomez Amoza J L ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Dissolution rate; Hydrochlorothiazide; Hydrophilic matrix tablets; Hydroxypropylmethylcellulose; Moisture content

Indexed keywords

CELLULOSE DERIVATIVE; EXCIPIENT; HYDROCHLOROTHIAZIDE;

ARTICLE; DRUG FORMULATION; DRUG SCREENING; HYDROPHILICITY; MOISTURE; PRIORITY JOURNAL; TABLET; TENSILE STRENGTH; VISCOSITY;

EID: 0030591417     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04467-1     Document Type: Article

References (7)

1. Fell, J.T. and Newton, J.M., Determination of tablet strength by diametral-compression test. J. Pharm. Sci., 59 (1970) 688-691.
2. nd Ed. Wade, A. and Weller, P.J. (Eds.), American Pharmaceutical Association and The Pharmaceutical Society of Great Britain, Washington, 1994, pp. 229-232.
3. Malamataris, S. and Karidas, T., Effect of particle size and sorbed moisture on the tensile strength of some tableted, hydroxypropyl methylcellulose (HPMC) polymers. Int. J. Pharm., 104 (1994) 115-123.
4. Malamataris, S., Karidas, T. and Goidas, P., Effect of particle size and sorbed moisture on the compression behaviour of some hydroxypropyl methylcellulose polymers. Int. J. Pharm., 103 (1994) 205-215.
5. Martínez-Pacheco, R., Gómez-Amoza, J.L. and Vila-Jato, J.L., Diseño de un sistema de registro de presión en máquinas de comprimir excéntricas. Cienc. Ind. Farm., 4 (1985) 207-211.
6. nd Ed., McGraw Hill, New York, 1988, pp. 206-212.
7. Vázquez, M.J., Pérez-Marcos, B., Gómez-Amoza, J.L., Martínez-Pacheco, R., Souto, C. and Concheiro, A., Influence of technological variables on release of drugs from hydrophyllic matrices. Drug Dev. Ind. Pharm., 18 (1992) 1355-1375.