The effect of nasal drug formulations on ciliary beating in vitro

International Journal of Pharmaceutics

Volumn 135, Issue 1-2, 1996, Pages 137-145

  Romeijn, Stefan G ^a   Verhoef, J Coos ^a   Marttin, Emmeline ^a   Merkus, Frans W H M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Absorption enhancers; Ciliary beat frequency; Nasal (non )prescription drug formulations; Preservatives

Indexed keywords

BENZALKONIUM CHLORIDE; CHLORBUTOL; CYCLODEXTRIN; DESMOPRESSIN; DIHYDROERGOTAMINE MESILATE; ESTRADIOL; OXYMETAZOLINE; SALCATONIN; XYLOMETAZOLINE;

ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CILIARY MOTILITY; DRUG ABSORPTION; DRUG EFFECT; DRUG FORMULATION; DRUG POTENTIATION; EMBRYO; NONHUMAN; PRIORITY JOURNAL; TRACHEA;

EID: 0030591401     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04460-2     Document Type: Article

References (24)

1. Ainge, G., Bowles, J.A.K., Mc Cormick, S.G., Richards, D.H. and Scales, M.D.C., Lack of deleterious effects of corticosteroid sprays containing benzalkonium chloride on nasal ciliated epithelium in vivo results in laboratory animals. Drug. Invest., 8 (1994) 127-133.
2. Andersen, I. and Proctor, D.F., Measurement of nasal mucociliary clearance. Eur. J. Resp. Dis., 64 (1983) 37-40.
3. Batts, A.H., Marriott, C., Martin, P., Wood, C.F., and Bond, W., The effect of some preservatives used in nasal preparations on the mucus and ciliary components of mucociliary clearance. J. Pharm. Pharmacol., 42 (1990) 145-151.
4. Cervin, A., Bende, M., Lindberg, S., Mercke, U. and Olsen, P., Relations between blood flow and mucociliary activity in the rabbit maxillary sinus. Acta Otolaryngol., 105 (1988) 350-356.
5. Chien, Y.W., Su, K.S.E. and Chang, S.F., Nasal Systemic Drug Delivery. Marcel Dekker, New York, 1989.
6. Critchley, H., Davis, S.S., Farraj, F. and Illum, L., Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J. Pharm. Pharmacol., 46 (1994) 651-656.
7. Fan, T.Y. and Wall, G.M., Determination of benzalkonium chloride in ophthalmic solutions containing tyloxapol by solid-phase extraction and reversed-phase high-performance liquid chromatography. J. Pharm. Sci., 82 (1993) 1172-1175.
8. Heinrichs, C., Craen, M., Vanderschueren-Lodeweyckx, M., Malvaux, P., Fawe, L. and Bourguignon, J.P., Variations in pituitary-gonadal suppression during intranasal buserelin and intramuscular depot-triptorelin therapy for central precocious puberty. Acta Paediatr., 83 (1994) 627-633.
9. Hermens, W.A.J.J., Hooymans, P.M., Verhoef, J.C. and Merkus, F.W.H.M., Effects of absorption enhancers on human nasal tissue ciliary movement in vitro. Pharm. Res., 7 (1990) 144-146.
10. Illum, L. and Davis, S.S., Intranasal insulin-clinical pharmacokinetics. Clin. Pharmacokinet., 23 (1992) 30-41.
11. Ingels, K.J.A.O., Kortman, M.J.W., Nijziel, M.R., Graamans, K. and Huizing, E.H., Factors influencing ciliary beat measurements. Rhinology, 29 (1991) 17-26.
12. Jacobs, M.A.J.M., Schreuder, R.H., Jap-A-Joe, K., Nauta, J.J., Andersen, P.M. and Heine, R.J., The pharmacodynamics and activity of intranasally administered insulin in healthy male volunteers. Diabetes, 42 (1993) 1649-1655.
13. Lansley, A.B., Mucociliary clearance and drug delivery via the respiratory tract. Adv. Drug. Deliv. Rev., 11 (1993) 299-327.
14. Lee, V.H.L., Yamamoto, A. and Kompella, U.B., Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit. Rev. Ther. Drug. Carrier Syst., 8 (1991) 91-192.
15. Marttin, E., Verhoef, J.C., Romeijn, S.G. and Merkus, F.W.H.M., Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity. Pharm. Res., 12 (1995) 1151-1157.
16. Merkus, F.W.H.M., Schipper, N.G.M., Hermens, W.A.J.J., Romeijn, S.G. and Verhoef, J.C., Absorption enhancers in nasal drug delivery: efficacy and safety. J. Controlled Release, 24 (1993) 201-208.
17. Overgaard, K., Angusdei, D., Hansen, M.A., Maioli, E., Christiansen, C. and Gennari, C., Dose-response bioactivity and bioavailability of salmon calcitonin in premenopausal and postmenopausal women. J. Clin. Endocrinol. Metab., 72 (1991) 344-349.
18. Rusznak, C., Devalia, J.L., Lozewicz, S. and Davies, R.J., The assessment of nasal mucociliary clearance and the effect of drugs. Resp. Med., 88 (1994) 89-101.
19. Schipper, N.G.M., Verhoef, J.C., Romeijn, S.G. and Merkus, F.W.H.M., Methylated ß-cyclodextrins are able to improve the nasal absorption of salmon calcitonin. Calcif. Tissue Int., 56 (1995) 280-282.
20. Stanley, P.J., Griffin, W.M., Wilson, R., Greenstone, M.A., Mackay, I.S. and Cole, P.J., Effect of betamethasone and betamethasone with neomycin nasal drops on human nasal mucociliary clearance and ciliary beat frequency. Thorax, 40 (1985) 607-612.
21. Su, X.Y., Li Wan Po, A. and Millership, J.S., Ciliotoxicity of intranasal formulations: menthol enantiomers. Chirality, 5 (1993) 58-60.
22. Van de Donk, H.J.M., Muller-Plantema, I.P., Zuidema, J. and Merkus, F.W.H.M., The effects of preservatives on the ciliary beat frequency of chicken embryo tracheas. Rhinology, 18 (1980) 119-133.
23. Van de Donk, H.J.M., Zuidema, J. and Merkus, F.W.H.M., The effect of nasal drops on the ciliary beat frequency of chicken embryo tracheas. Rhinology, 19 (1981) 215-230.
24. Van de Donk, H.J.M., Zuidema, J. and Merkus, F.W.H.M., Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs. Rhinology, 20 (1982) 81-87.