Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression

Journal of Affective Disorders

Volumn 41, Issue 3, 1996, Pages 201-210

  Maes, Michael ^a,b   Vandoolaeghe, Eric ^a   Desnyder, Roger ^a  

^a Clinical Research Center for Mental Health of Antwerp   (Belgium)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

5 HT(1A) receptor; fluoxetine; pindolol; serotonin; trazodone; treatment resistant depression

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BUSPIRONE; CITALOPRAM; FLUOXETINE; IMIPRAMINE; LITHIUM; MAPROTILINE; MOCLOBEMIDE; NORTRIPTYLINE; OPIPRAMOL; PHENELZINE; PINDOLOL; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFICACY; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FLUOXETINE; HUMANS; MALE; MIDDLE AGED; PERSONALITY INVENTORY; PINDOLOL; SEROTONIN ANTAGONISTS; TRAZODONE;

EID: 0030590818     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(96)00089-4     Document Type: Article

References (51)

1. Amsterdam, J.D., Maislin, G. and Potter, L. (1994) Fluoxetine efficacy in treatment resistant depression. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 18, 243-261.
2. APA (1987) Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC.
3. Aranow, R.B., Hudson, J.I., Pope, H.G., Grady, T.A., Laage, T.A., Bell, I.R. and Cole, J.O. (1989) Elevated antidepressant plasma levels after addition of fluoxetine. Am. J. Psychiatry 146, 911-913.
4. IA receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely and chronically with citalopram. Naunyn-Schmiedeberg's Arch. Pharmacol. 352, 157-165.
5. Artigas, F., Perez, V. and Alvarez, E. (1994) Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch. Gen. Psychiatry 51, 248-251.
6. Artigas, F. (1995) Pindolol, 5-hydroxytryptamine, and antidepressant augmentation. Arch. Gen. Psychiatry 52, 969-971.
7. Bakish, D. (1994) Potentiation of fluoxetine by buspirone and trazodone in refractory depression, in W.A. Nolen, J. Zohar, S.P. Roose and J.A. Amsterdam (Eds.), Refractory Depression: Current Strategies and Future Directions. John Wiley & Sons, Chichester, pp. 143-146.
8. Beasly, C.M., Sayler, M.E., Cunningham, G.E., Weiss, A.M. and Masica, D.N. (1990) Fluoxetine in tricyclic refractory major depressive disorder. J. Affect. Disord. 20, 193-200.
9. Beasly, C.M., Masica, D.N. and Potvin, J.H. (1992) Fluoxetine: a review of receptors and functional effects and their clinical implications. Psychopharmacology 107, 1-10.
10. Blier, P., de Montigny, C. and Chaput, Y. (1988) Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5HT neurotransmission. Clin. Neuropharmacol. 11, 1-10.
11. Blier, P., de Montigny, G. and Chaput, Y. (1990) A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. J. Clin. Psychiatry 51, 14-20.
12. Briley, M. and Moret, C. (1993) Neurobiological mechanisms involved in antidepressant therapies. Clin. Neuropharmacol. 16, 387-400.
13. Chaput, Y., De Montigny, C. and Blier, P. (1991) Pre- and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments: an in vivo electrophysiological study in the rat. Neuropsychopharmacology 5, 219-227.
14. Charney, D.S., Heninger, G.R. and Sternberg, D.E. (1984) Serotonin function and mechanism of action of antidepressant treatment: effects of amitriptyline and desipramine. Arch. Gen. Psychiatry 41, 359-365.
15. Clements-Jewery, S. (1978) The development of cortical β-adren-oceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserin. Neuropharmacology 17, 779-781.
16. Cole, J.O., Schatzberg, A.F., Sniffin, C., Zolner, J. and Cole, J.P. (1981) Trazodone in treatment-resistant depression: an open study. J. Clin. Psychopharmacol. 1 (Suppl.), 49-54.
17. de Montigny, C. (1994) Lithium addition in refractory depression. In W.A. Nolen, J. Zohar, S.P. Roose and J.A. Amsterdam (Eds.), Refractory Depression: Current Strategies and Future Directions. John Wiley & Sons, Chichester, pp. 47-57.
18. Dowdall, M. and de Montigny, C. (1984) Pre- and postsynaptic effects of trazodone on serotonin neurotransmission: single cell studies in the rat. Psychother Drugs, Abstracts Sci. Neorosci. 10, 17.
19. Fuller, R.W. (1988) L-phenylpiperazines and related compounds as centrally acting serotonin agonists, in R.H. Resh and G.A. Gudelsky (Eds.), 5-HT Agonists as Psychotropic Drugs. NPP Books, Ann Arbor, MI, pp. 35-60.
20. Fuller, R.W. (1994) Minireview. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci. 55, 163-167.
21. Gorman, J.M. and Hatterer, J.A. (1994) The role of thyroid hormone in refractory depression. In W.A. Nolen, J. Zohar, S.P. Roose and J.A. Amsterdam (Eds.), Refractory Depression: Current Strategies and Future Directions. John Wiley & Sons, Chichester, pp. 121-128.
22. Gurevich, E.V., Aleksandrova, I.A., Otmakhova, N.A., Katkov, Y.A., Nesterova, I.V., Bobkova, N.V. (1993) Effects of bulbectomy and subsequent antidepressant treatment on brain 5-HT2 and 5-HT1A receptors in mice. Pharmacol. Biochem. Behav. 45, 65-70.
23. Guscott, R. and Grof, P. (1991) The clinical meaning of refractory-depression: a review for the clinician. Am. J. Psychiatry 148, 695-704.
24. Hamik, P. and Peroutka, S. (1989) mCPP interactions with neuro-transmitter receptors in the human brain. Biol. Psychiatry 25, 569-575.
25. Hamilton, M. (1960) A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23, 56-61.
26. Hjorth, S. and Carlsson, A. (1986) Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors. Eur. J. Pharmacol. 129, 131-138.
27. Hjorth, S. (1992) Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J. Neurochem. 60, 776-779.
28. Hoes, MJ.AJ.M. (1984) Trazodon. Pharm. Weekbl. 119, 973-980.
29. Howell, D.C. (1982) Multiple comparisons among treatment means, in D.C. Howell (Ed.) Statistical Methods for Psychology. Duxbury Press, Boston, MA, pp. 289-307.
30. Kahn, R.S. and Wetzler, S. (1991) m-Chlorophenylpiperazine as a probe of serotonin receptors: a review. Biol. Psychiatry 30, 1139-1166.
31. Keller, M.B., Klerman, G.L., Lavori, P.W., et al. (1984) Long-term outcome of episodes of major depression: clinical and public health significance. J. Am. Med. Ass. 252, 758-792.
32. Maes, M. and Meltzer, H.Y.M. (1995) The serotonin hypothesis of major depression, in F.E. Bloom and D.J. Kupfer (Eds.) Psychopharmacology, the Fourth Generation of Progress. Raven Press, New York, NY, pp. 933-944.
33. Marek, G.J., McDougle, C.J., Price, L.H. and Seiden, L.S. (1992) A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. Psychopharmacology 109, 2-11.
34. Meltzer, H. Y., Maes, M. and Elkis, H. (1994) The biological basis of refractory depression, in W.A. Nolen, J. Zohar, S.P. Roose and J.A. Amsterdam (Eds.), Refractory Depression: Current Strategies and Future Directions. John Wiley & Sons, Chichester, pp. 177-198.
35. Meltzer, H.Y. and Maes, M. (1994) Effects of pindolol on 5-HTP-induced prolactin and cortisol responses. Psychopharmacology 114, 635-643.
36. Meltzer, H.Y. and Maes, M. (1995) Pindolol pretreatment blocks stimulation by mCPP of prolactin but not cortisol secretion in normal man. Psychiatr. Res. 58, 89-98.
37. Nierenberg, A.A., Cole, J.O. and Glass, L. (1992) Possible trazodone potentiation of fluoxetine: a case series. J. Clin. Psychiatry 53, 83-85.
38. Nilsen, O.G., Dale, O. and Husebo, B. (1993) Pharmacokinetics of trazodone during multiple dosing to psychiatric patients. Pharmacol. Toxicol. 72, 286-289.
39. 125I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments. J. Pharmacol. Exp. Ther. 257, 681-690.
40. Preskorn, S.H. and Magnus, R.D. (1994) Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care. Psychopharmacol. Bull. 30, 251-259.
41. Price, L.H., Charney, D.S., Delgado, P.L., et al. (1989) Effects of desipramine and fluvoxamine treatment of the prolactin response to tryptophan: serotonergic function and the mechanism of antidepressant action. Arch. Gen. Psychiatry 46, 625-631.
42. Reimherr, F.W., Wood, D.R., Byerly, B., Brainard, J. and Grosser, B. (1984) Characteristics of responders to fluoxetine. Psychopharmacol. Bull. 20, 70-73.
43. Riblet, L.A. and Taylor, D.P. (1981) Pharmacology and neurochemistry of trazodone. J. Clin. Psychopharmacol. 1, 17S-22S.
44. Roose, S.P., Classman, A.H., Walsh, B.T. and Woodring, S. (1986) Tricyclic nonresponders: phenomenology and treatment. Am. J. Psychiatry 143, 345-348.
45. Rosenthal, J.S., Kaswan, M.J., Hemlock, C. and Winston, A. (1991) Fluoxetine enhancement of heterocyclic antidepressants, in J.D. Amsterdam (Ed.), Advances in Neuropsychiatry and Psychopharmacology, Vol. 2, Refractory Depression. Raven Press, New York, NY, pp. 105-108.
46. Shapira, B., Cohen, J., Newman, M.E. and Lerer, B. (1992) Prolactin response to fenfluramine and placebo challenge following maintenance pharmacotherapy withdrawal in remitted depressed patients. Biol. Psychiatry 33, 531-535.
47. Solyom, L. and Gibson, R.E. (1990) Fluoxetine in refractory depression. Biol. Psychiatry 27, 461-463.
48. Spitzer, R.L., Williams, J.B.W., Gibbon, M. and First, M.B. (1990) Structured Clinical Interview according to DSM-III-R. American Press, New York, NY.
49. Sulser, F. (1983) Mode of action of antidepressant drugs. J. Clin. Psychiatry 44, 14-20.
50. Thase, M.E. and Rush, A.J. (1995) Treatment-resistant depression, in F.E. Bloom and D.J. Kupfer (Eds.), Psychopharmacology, the Fourth Generation of Progress. Raven Press, New York, NY, pp. 1081-1098.
51. Wong, D.T., Bymaster, F.P. and Engleman, E.A. (1995) Minireview. Prozac (Fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci. 51, 411-441.