Augmented release of serotonin by adenosine A(2a) receptor activation and desensitization by CGS 21680 in the rat nucleus tractus solitarius

Brain Research

Volumn 733, Issue 2, 1996, Pages 155-161

  Barraco, Robin A ^a   Helfman, Carolyn Clough ^a   Anderson, Gordon F ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine A(2a) receptor; Adenosine receptor; CGS 21680; Nucleus tractus solitarius; Receptor desensitization; Serotonin

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 6 NITROQUIPAZINE; 8 (3 CHLOROSTYRYL)CAFFEINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; CAFFEINE DERIVATIVE; PRESYNAPTIC RECEPTOR; PROTRIPTYLINE; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SEROTONIN RELEASE; SOLITARY TRACT NUCLEUS;

EID: 0030590536     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00279-X     Document Type: Article

References (39)

1. 2a receptors associated with norepinephrine release and their desensitization in the rate nucleus tractus solitarius. J. Neurochem. 65:1995;1604-1611.
2. Barraco R.A., Janusz C.J., Polasek P.M., Parizon M., Roberts P.A. Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius. Brain Res. Bull. 20:1988;129-132.
3. Barraco R.A., El-Ridi M.R., Ergene E., Phillis J.W. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26:1991;59-84.
4. Barraco R., El-Ridi M., Ergene E., Parizon M., Bradley D. An atlas of the rat subpostremal nucleus tractus solitarius. Brain Res. Bull. 29:1992;703-765.
5. 3H]nitrobenzylthioinosine. J. Neurosci. 5:1985;554-550.
6. 2a receptors on soma and central terminals of rat vagal afferent neurons. Brain Res. 652:1994;137-144.
7. 2a-adenosine receptor of the rat motor nerve endings is positively coupled to adenylate cyclase. Naunyn-Schmiedeberg's Arch. Pharmacol. 350:1994;514-522.
8. 2a receptors in the rat hippocampus. Brain Res. 649:1994;208-216.
9. Fredholm B.B., Abbracchio N.P., Burnstock G., Daly J.W., Harden T.K., Jacobson K.A., Leff P., Williams M. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46:1994;143-156.
10. 2a adenosine receptors from rat striatum and rat pheochromocytoma PC 12 cells: Characterization with radioligand binding and by activation of adenylate cyclase. Mol. Pharmacol. 41:1992;352-359.
11. Itoh H., Bunag R.D. Cardiovascular and sympathetic effects of injecting serotonin into the nucleus tractus solitarius in rats. J. Pharmacol. Exp. Ther. 256:1991;1147-1153.
12. Jacobson K.A., van Galen P.J.M., Williams M. Adenosine receptors: Pharmacology, structure-activity relationships, and therapeutic potential. J. Med. Chem. 35:1992;407-422.
13. 2-adenosine antagonist in vitro and in vivo. FEBS Lett. 323:1993;141-144.
14. 2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices. J. Pharmacol. Exp. Ther. 267:1993;801-808.
15. 3H]CGS 21680 to rat cortex differs from its binding to rat striatum. Eur. J. Pharmacol. 247:1993;103-110.
16. 3H]acetylcholine release. J. Neurochem. 62:1994;960-966.
17. Kirkpatrick K.A., Richardson P.J. Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes. Br. J. Pharmacol. 110:1993;949-954.
18. Laguzzi, R., Serotonergic mechanisms in baroreceptor afferent processing and cardiovascular control by the NTS. In I.R. Barraco (Ed.), Nucleus of the Solitary Tract, CRC Press, Boca Raton, 1994, pp. 193-206.
19. 3H]Adenosine transport in rat dorsal brainstem using a crude synaptosomal preparation. Neurochem. Int. 25:1994;221-226.
20. Maley B., Elde R. Immunohistochemical localization of putative neurotransmitters with the feline nucleus tractus solitarius. Neuroscience. 7:1982;2469-2490.
21. 2+ ion. Biochim. Biophys. Acta. 1120:1993;76-84.
22. 2a receptor modulation of electrically evoked endogenous GABA release from slices of rat globus pallidus. J. Neurochem. 60:1993;2334-2337.
23. 2a adenosine receptor from guinea pig brain. Neurochem. Res. 19:1994;613-621.
24. 2 receptors in the nucleus tractus solitarius characterization and role in cardiovascular regulation in the rat. Brain Res. 575:1992;74-78.
25. Okada Y., Nishimura S., Miyamoto T. Excitatory effect of adenosine on neurotransmission in the slices of superior colliculus and hippocampus of guinea pig. Neurosci. Lett. 120:1990;205-208.
26. 2a adenosine receptor: Delineation of multiple processes. Mol. Pharmacol. 45:1994;1082-1094.
27. 1 MF-2 cells. Mol. Pharmacol. 40:1991;639-647.
28. Ruggiero, D.A., Pickel, V.M., Milner, T.A., Anwar, N., Otake, K., Ntui, E.P. and Park, D. Viscerosensory processing in nucleus tractus solitarii: structural and neurochemical correlates. In R. Barraco (Ed.), Nucleus of the Solitary Tract. CRC Press, Boca Raton, 1994, pp. 3-34.
29. 2 adenosine receptors in the rat hippocampus. Neurosci. Lett. 138:1992;41-44.
30. Schaffar N., Kessler J.P., Bosler O., Jean A. Central serotoninergic projections to the nucleus tractus solitarii: evidence form a double labeling study in the rat. Neuroscience. 26:1988;951-958.
31. Shvaloff A., Laguzzi R. Serotonin in the rat nucleus tractus solitarii and cardiovascular regulation. Eur. J. Pharmacol. 132:1986;283-288.
32. Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience. 6:1981;557-618.
33. Steinbusch H.W.M., Verhofstad A.A.J., Joosten H.W.J. Localization of serotonin in the central nervous system by immunohistochemistry: description of a specific and sensitive technique and some applications. Neuroscience. 3:1978;811-819.
34. Tao S., Abdel-Rahman A.A. Neuronal and cardiovascular responses to adenosine microinjection into the nucleus tractus solitarius. Brain Res. Bull. 32:1993;407-417.
35. Thor K.B., Hill K.M., Harrod C., Helke C.J. Immunohistochemical and biochemical analysis of serotonin and substance P colocalization in the nucleus tractus solitarii and associated afferent ganglia of the rat. Synapse. 2:1988;225-231.
36. Thor K.B., Helke C.J. Serotonin and substance P-containing projections to the nucleus tractus solitarii of the rat. J. Comp. Neurol. 265:1978;275-293.
37. Van Giersbergen P.L., Palkovits M., De Jong W. Involvement of neurotransmitters in the nucleus tractus solitarii in cardiovascular regulation. Physiol. Rev. 72:1992;789-824.
38. 3H]CGS 21680 to human and rat brain: Evidence for multiple affinity sites. J. Neurochem. 55:1990;1763-1771.
39. Wolf W.A., Kuhn D.M., Lovenberg W. Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. Eur. J. Pharmacol. 69:1981;291-299.