Exploitation of highly functionalised epoxides derived from asymmetrized tris(hydroxymethyl)methane (THYM*) in the synthesis of a fragment of lasalocide A and other related polyether ionofore antibiotics

Tetrahedron

Volumn 52, Issue 38, 1996, Pages 12631-12642

  Guanti, Giuseppe ^a   Narisano, Enrica ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IONOPHORE; LASALOCID; POLYETHER ANTIBIOTIC AGENT;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030590467     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4020(96)00751-X     Document Type: Article

References (24)

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6. 5. Actually, thank to enantiodivergency of THYM* derivatives, either enantiomeric form of epoxides 1 were used at times in this work, but, for sake of simplicity, the same enantiomer is generally used in Schemes and discussion.
7. 6. Stereoselective Deoxygenation of epoxides to olefins has been reported using lower valent tungsten halides, as well as other metals or metal derivatives (see Umbreit, M.; Sharpless, K. B. Org. Synth. 1981, 60, 29-33 and references therein).
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