Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA

Brain Research

Volumn 733, Issue 2, 1996, Pages 184-192

  Tersigni, Timothy J ^a   Rosenberg, Howard C ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

2 Hydroxypropyl cyclodextrin; Cannabinoid; Iontophoresis; Local drug delivery; Striatonigral; Substantia nigra; Aminobutyric acid inhibition

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 AMINOBUTYRIC ACID; BICUCULLINE; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; RIMONABANT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; ELECTROPHYSIOLOGY; INTRAVENOUS DRUG ADMINISTRATION; IONTOPHORESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

EID: 0030590437     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00533-1     Document Type: Article

References (43)

1. Abood M.E., Martin B.R. Neurobiology of marijuana abuse. Trends Pharmacol. Sci. 13:1992;201-206.
2. Anderson J.J., Kask A.M., Chase T.N. Effects of cannabinoid receptor stimulation and blockade on catalepsy produced by dopamine receptor agonists. Eur. J. Pharmacol. 295:1996;163-168.
3. 2 agonist in rats with unilateral lesions of the nigrostriatal pathway. Brain Res. 691:1995;106-114.
4. Baumeister A.A., Hawkins M.F., Anderson-Moore L.L., Anticich T.G., Higgins T.D., Griffin P. Effects of bilateral injection of GABA into the substantia nigra on spontaneous behavior and measures of analgesia. Neuropharmacology. 27:1988;817-821.
5. Devane W.A., Dysarz F.A. III, Johnson M.R., Melvin L.S., Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34:1988;605-613.
6. 9-tetrahydrocannabinol, CP 55,940 and Win 55,212-2. J. Pharmacol. Exp. Ther. 271:1994;1383-1390.
7. Fan F., Tao Q., Abood M., Martin B.R. Cannabinoid receptor down-regulation without alteration of the effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940 tolerant mice. Brain Res. 706:1996;13-20.
8. Feeney D.M., Marihuana and epilepsy: Paradoxical anticonvulsant and convulsant effects Adv. Biosci. 22-23:1978;643-657.
9. Frye G.D., Baumeister A.A., Crotty K., Newman K.D., Kotrla K.J. Evaluation of the role of antinociception in self-injurious behavior following intranigral injection of muscimol. Neuropharmacology. 25:1986;717-726.
10. Gale K. Progression and generalization of seizure discharge: anatomical and neurochemical substrates. Epilepsia. 29(S2):1988;S15-S34.
11. Glass M., Faull R.L.M., Dragunow M. Loss of cannabinoid receptors in the substantia nigra in Huntington's disease. Neuroscience. 56:1993;523-527.
12. 9-THC in the rat. Neuropharmacology. 17:1978;137-144.
13. 9 dopamine neuronal activity in the rat. NeuroReport. 6:1995;1293-1297.
14. Herkenham M., Lynn A.B., de Costa B.R., Richfield E.K. Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res. 547:1991;267-274.
15. Herkenham M., Lynn A.B., Little M.D., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. USA. 87:1990;1932-1936.
16. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. 11:1991;563-583.
17. Jansen E.M., Haycock D.A., Ward S.J., Seybold V.S. Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res. 575:1992;93-102.
18. Karler R., Tukanis S.A. Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice. Br. J. Pharmacol. 68:1980;479-484.
19. Kolasiewicz W., Cools A., Ossowska K., Wolfarth S. The neostriatal inhibition of catalepsy, but not of muscle rigidity, evoked from the substantia nigra pars reticulata. Pharmacol. Biochem. Behav. 28:1987;453-457.
20. Mailleux P., Vanderhaeghen J.J. Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neurons. Neurosci. Lett. 148:1992;173-176.
21. Mailleux P., Vanderhaeghen J.J. Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience. 48:1992;655-668.
22. 1 receptors on striatonigral terminals via a pertussis toxin-sensitive coupling pathway. J. Neurosci. 14:1994;4494-4508.
23. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
24. Mechoulm R., Hanus L., Martin B.R. Search for endogenous ligands of the cannabinoid receptor. Biochem. Pharmacol. 48:1994;1537-1544.
25. Melvin L.S., Milne G.M., Johnson M.R., Subramaniam B., Wilken G.H., Howlett A.C. Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs. Mol. Pharmacol. 44:1993;1008-1015.
26. Miller A.S., Walker J.M. Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata. Eur. J. Pharmacol. 279:1995;179-185.
27. 9-tetrahydrocannabinol: possible involvement of nigrostriatal dopaminergic alterations. Pharmacol. Biochem. Behav. 45:1993;291-298.
28. Olpe H.-R., Koella W.P., Wolfe P., Haas H.L. The action of baclofen on neurons of the substantia nigra and of the ventral tegmental area. Brain Res. 134:1977;577-580.
29. Oviedo A., Glowa J., Herkenham M. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain Res. 616:1993;293-302.
30. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1982.
31. Richfield E.K., Herkenham M. Selective vulnerability in Huntington's Disease: preferential loss of cannabinoid receptors in lateral globus pallidus. Ann. Neurol. 36:1994;577-584.
32. Rinaldi-Carmona M., Barth F., Heaulme M., Alonso R., Shire D., Congy C., Soubrie P., Breliere J.-C., Le Fur G. Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 55:1995;941-1947.
33. 9-tetrahydrocannabinol. Pharmacol. Biochem. Behav. 51:1995;731-737.
34. Rubino T., Massi P., Patrini G., Venier I., Giagnoni G., Parolaro D. Chronic CP 55940 alters cannabinoid receptor mRNA in the rat brain: an in situ hybridization study. NeuroReport. 5:1994;2493-2496.
35. Souilhac J., Poncelet M., Rinaldi-Carmona M., Le Fur G., Soubrie P. Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice. Pharmacol. Biochem. Behav. 51:1995;3-7.
36. Turski L., Havemann U., Kuschinsky K. GABAergic mechanisms in mediating muscular rigidity, catalepsy and postural asymmetry in rats: differences between dorsal and ventral striatum. Brain Res. 322:1984;49-57.
37. Turski L., Klockgether T., Turski W., Schwarz M., Sontag K. Substantia nigra and motor control in the rat: effect of intranigral α-kainate and γ-D-glutamylaminomethylsulphonate on motility. Brain Res. 424:1987;37-48.
38. Tyma J., Rosenberg H.C., Tietz E.I., Chiu T.H. Effects of chronic flurazepam treatment on firing rate of rat substantia nigra pars reticulata neurons. Brain Res. 453:1988;344-348.
39. Wada J.A., Osawa T., Corcoran M.E. Effects of tetrahydrocannabinols on kindled amygdaloid seizures and photogenic seizures in senegalese baboons. Papio papio, Epilepsia. 16:1975;439-448.
40. Waszczak B.L., Eng N., Walters J.R. Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons. Brain Res. 188:1980;185-197.
41. Zhang H., Rosenberg H.C., Tietz E.I. Injection of benzodiazepines but not GABA or muscimol into pars reticulata of substantia nigra suppresses pentylenetetrazol seizures. Brain Res. 488:1989;73-79.
42. Zhang H., Rosenberg H.C., Tietz E.I. Anticonvulsant actions and interactions of GABA agonists and a benzodiazepine in pars reticulata of substantia nigra. Epilepsy Res. 8:1991;11-20.
43. Zhang H., Weng X., Rosenberg H.C. Characterization of substantia nigra pars reticulata neurons based on response to iontophoretically applied GABA and flurazepam. Life Sci. 53:1993;1911-1919.