Synthesis of functionalised cyclic pentapeptide analogues of the serine-threonine protein phosphatase inhibitor nodularin

Tetrahedron Letters

Volumn 37, Issue 38, 1996, Pages 6915-6918

  Mehrotra, Amit P ^a   Gani, David ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; ENZYME INHIBITOR; NODULARIN; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR;

ARTICLE; DRUG DESIGN; MASS SPECTROMETRY; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; REACTION ANALYSIS;

EID: 0030590397     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01515-8     Document Type: Article

References (14)

1. 1. Hunter, T. Cell, 1995, 80, 225.
2. 2. a) Cohen, P. Annu. Rev. Biochem., 1989, 58, 453;
3. b) Cohen, P. T. W.; Brewis, N. D.; Hughes, V.; Mann, D. J. FEBS Lett., 1990, 268, 355.
4. 3. Carmichael, W. W. J. Applied Bacteriol., 1992, 72, 445.
5. 4. Honkanen, R. E.; Zwiller, J.; Daily, S. L.; Khatra, B. S.; Dukelow, M.; Boynton, A. L. J. Biol. Chem., 1991, 266, 6614.
6. 5. Holmes, C. F. B.; Boland, M. P. Curr. Opin. Struct. Biol., 1993, 3, 934.
7. 6. Goldberg, J.; Huang, H. -B.; Kwon, Y. -G.; Greengard, P.; Nairn, A. C.; Kuriyan, J. Nature, 1995, 376, 745.
8. 7. Fujiki, H.; Suganuma, M.; Yatsunami, J.; Komori, A.; Okabe, S.; Nishiwaki-Matsushima, R.; Ohta, T. Gazz. Chim. Ital., 1993, 123, 309.
9. 8. Namikoshi, M.; Choi, B. W.; Sakai, R.; Rinehart, K. L.; Carmichael, W. W.; Evans, W. R.; Cruz, P.; Munro, M. H. G.; Blunt, J. W. J. Org. Chem., 1994, 59, 2349.
10. 9. Mehrotra, A. P. Ph. D. Thesis, University of St. Andrews, 1995.
11. 10. a) Runnegar, M.; Berndt, N.; Kong, S. -M.; Lee, E. Y. C.; Zhang, L. Biochem. Biophys. Res. Commun., 1995, 216, 162;
12. b) MacKintosh, R. W.; Dalby, K. N.; Campbell, D. G.; Cohen, P.; MacKintosh, C. FEBS Lett., 1995, 371, 236.
13. A, AHB), 5.68 (1H, d, J 7.9, NH, Glu), 6.67 (1H, d, J 7.3, NH, Phe), 7.17-7.33 (5H, m, aromatic), 7.37 (1H, d, J 6.5, NH, Asp) and 7.47 (1H, d, J 5.8, NH, AHB), full details will appear elsewhere.
14. 12. Valentekovich, R. J.; Schreiber, S. L. J. Am. Chem. Soc., 1995, 117, 9069.