Molecular cloning and kinetic characterization of a flavin-containing monooxygenase from Saccharomyces cerevisiae

Archives of Biochemistry and Biophysics

Volumn 336, Issue 2, 1996, Pages 268-274

  Suh, Jung Keun ^a   Poulsen, Lawrence L ^a   Ziegler, Daniel M ^a   Robertus, Jon D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

bacterial expression; kinetic analysis; thiol metabolism

Indexed keywords

DIMETHYLANILINE MONOOXYGENASE; MERCAPTAMINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE; MOLECULAR CLONING; OPEN READING FRAME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FELIS CATUS; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0030589542     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1996.0557     Document Type: Article

References (22)

1. 1. Korzekwa, K. R., and Jones, J. P. (1993) Pharmacogenetics 3, 1-18.
2. 2. Coon, M. J., Ding, X. X., Pernecky, S. J., and Vaz, A. D. (1992) FASEB J. 6, 669-673.
3. 3. Ziegler, D. M. (1993) Annu. Rev. Pharmacol. Toxicol. 33, 1979-1999.
4. 4. Hines, R. N., Cashman, J. R., Philpot, R. M., Williams, D. E., and Ziegler, D. M. (1994) Toxicol. Appl. Pharmacol. 125, 1-6.
5. 5. Schlenk, D., and Buhler, D. R. (1989) Comp. Biochem. Physiol. 94, 469-75.
6. 6. Ziegler, D. M. (1991) In N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology (Hlavic, P., and Damani, L. A., Eds.), pp. 50-70, Chapman and Hall, London.
7. 7. Lemoine, A., Williams, D. E., Cresteil, T., and Leroux, J. P. (1991) Mol. Pharmacol. 40, 211-217.
8. 8. Poulsen, L. L., and Ziegler, D. M. (1995) Chem-Biol. Interact. 96, 57-73.
9. 9. Poulsen, L. L. (1991) In Chemistry and Biochemistry of Flavoenzymes (F. Miller, Ed.), Vol. 2, pp. 87-100, CRC Press, Boca Raton, FL.
10. 10. Poulsen, L. L., and Ziegler, D. M. (1979) J. Biol. Chem. 254, 6449-6455.
11. 11. Gasser, R., Tynes, R. E., Lawton, M. P., Korsmeyer, K. K., Ziegler, D. M., and Philpot, R. M. (1990) Biochemistry 29, 119-124.
12. 12. Dolphin, C., Shephard, E. A., Povey, S., Palmer, C. N., Ziegler, D. M., Ayesh, R., Smith, R. L., and Phillips, I. R. (1991) J. Biol. Chem. 266, 12379-12385.
13. 13. Lawton, M. P., Cashman, J. R., Cresteil, T., Dolphin, C. T., Elfarra, A. A., Hines, R. N., Hodgson, E., Kimura, T., Ozols, J., Phillips, I. R., et al. Arch. Biochem. Biophys. 308, 254-257.
14. 14. Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et al. (1994) Science 265, 2077-2082.
15. 15. Eckert, K. A., and Kunkel, T. A. (1990) Nucleic Acids Res. 18, 3739-3744.
16. 16. Birnboim, H. C., and Doly, J. (1979) Nucleic Acids Res. 7, 1513-1523.
17. 17. Glenn, E. D., Schonfeld, H. S., Langen, H., and Stieger, M. (1994) Protein Eng. 7, 925-931.
18. 18. Mittl, P. R., and Schulz, G. E. (1994) Protein Sci. 3, 799-809.
19. 19. Kemal, C., and Bruice, T. C. (1976) Proc. Natl. Acad. Sci. USA 73, 995-999.
20. 20. Ziegler, D.M. (1991) Adv. Exp. Med. Biol. 283, 41-50.
21. 21. Ziegler, D. M., and Poulsen, L. L. (1977) Trends Biochem. Sci. 2, 79-82.
22. 22. Salhany, J. M., Yamane, T., Shulman, R. G., and Ogawa, S. (1975) Proc. Natl. Acad. Sci. USA 72, 4966-4970.