Expression of neuronal nitric oxide synthase in spinal motoneurons in aged rats

Neuroscience Letters

Volumn 219, Issue 1, 1996, Pages 41-44

  Kanda, K ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Aging; Cell death; Motoneuron; Nicotinamide adenine dinucleotide phosphate diaphorase; Nitric oxide; Rat

Indexed keywords

NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ADOLESCENT; AGED; AGING; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; HISTOCHEMISTRY; MALE; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

AGING; ANIMALS; MALE; MOTOR NEURONS; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED F344; SPINAL CORD;

EID: 0030589187     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13170-0     Document Type: Article

References (34)

1. [1] Dawson, T.M., Bredt, D.S., Fotuhi, M., Hwang, P.M. and Snyder, S.H., Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues, Proc. Natl. Acad. Sci. USA, 88 (1991) 7797-7801.
2. [2] Dawson, T.M. and Dawson, V.L., Nitric oxide: actions and pathological roles, Neuroscientist (Preview issue), (1994) 9-20.
3. [3] Doherty, T.J., Vandervoort, A.A., Taylor, A.W. and Brown, W.F., Effects of motor unit losses on strength in older men and women, J. Appl. Physiol., 74 (1993) 868-874.
4. [4] Dun, N.J., Dun, S.L., Forstermann, U. and Tseng, L.F., Nitric oxide synthase immunoreactivity in rat spinal cord, Neurosci. Lett., 147 (1994) 217-220.
5. [5] Gonzalez, M.F., Sharp, F.R. and Sagar, S.M., Axotomy increases NADPH-diaphorase staining in rat vagal motor neurons, Brain Res. Bull., 18 (1987) 417-427.
6. [6] Gutmann, E., Hanzlíková, V. and Vyskocil, F., Age changes in cross striated muscle of the rat, J. Physiol., 216 (1971) 331-343.
7. [7] Hashizume, K. and Kanda, K., Differential effects of aging on motoneurons and peripheral nerves innervating the hindlimb and forelimb muscles of rats, Neurosci. Res., 22 (1995) 189-196.
8. [8] Hashizume, K., Kanda, K. and Burke, R.E., Medial gastrocnemius motor nucleus in the rat: Age-related changes in the number and size of motoneurons, J. Comp. Neurol., 269 (1988) 425-430.
9. [9] Hefti, F., Hartikka, J. and Knusel, B., Function of neurotrophic factors in the adult and aging b rain and their possible use in the treatment of neurodegenerative diseases, Neurobiol. Aging, 10 (1989) 515-533.
10. [10] Hope, B.T., Michael, G.J., Knigge, K.M. and Vincent, S.R., Neuronal NADPH diaphorase is a nitric oxide synthase, Proc. Natl. Acad. Sci. USA, 88 (1991) 2811-2814.
11. [11] Hope, B.T. and Vincent, S.R., Histochemical characterization of neuronal NADPH-diaphorase, J. Histochem. Cytochem., 37 (1989) 653-661.
12. [12] Johnson, E.M. Jr., Chang, J.Y., Kioke, T. and Martin, D.P., Why do neurons die when deprived of trophic factors?, Neurobiol. Aging, 10 (1989) 549-552.
13. [13] Johnson, H., Mossberg, K., Arvidsson, U., Piehl, F., Hökfelt, T. and Ulfhake, B., Increase in a-CGRP and GAP-43 in aged motoneurons: a study of peptides, growth factors, and ChAT mRNA in the lumbar spinal cord of senescent rats with symptoms of hindlimb incapabilities, J. Comp. Neurol., 359 (1995) 69-89.
14. [14] Johnson, I.P., Sears, T.A. and Hunter, A.S., Retrograde response to axotomy of motoneurons in the thoracic spinal cord of the aging cat, Neurobiol. Aging, 12 (1991) 151-160.
15. [15] Kanda, K. and Hashizume, K., Changes in properties of the medial gastrocnemius motor units in aging rat, J. Neurophysiol., 61 (1989) 737-746.
16. [16] Kanda, K., Hashizume, K., Miwa, T. and Miwa, Y., Overloading a muscle does not alter the rate of motoneuronal loss in aged rats, Neurobiol. Aging, 17 (1996) 613-617.
17. [17] Kawamura, Y. and Dyck, P.J., Permanent axotomy by amputation results in loss of motor neurons in man, J. Neuropathol. Exp. Neurol., 40 (1981) 658-666.
18. [18] Kawamura, Y., O'Brien, P., Okazaki, H. and Dyck, P.J., Lumbar motoneurons of man II: the number and diameter distribution of large-and intermediate-diameter cytons in 'motoneuron columns' of spinal cord of man, J. Neuropathol. Exp. Neurol., 36 (1977) 861-870.
19. [19] Koliatsos, V.E., Price, W.L., Pardo, C.A. and Price, D.L., Ventral root avulsion: an experimental model of death of adult motor neurons, J. Comp. Neurol., 342 (1994) 35-44.
20. [20] Kuno, M., Target dependence of motoneuronal survival: the current status, Neurosci. Res., 9 (1990) 155-172.
21. [21] McElhaney, M.R., Chandler, L.J. and Streif, W.J., Astrocytes but not microglia express NADPH-diaphorase activity after motor neuron injury in the rat, Neurosci. Lett., 180 (1994) 67-70.
22. [22] Novikov, L., Novikova, L. and Kellerth, J.-O., Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion, Neurosci. Lett., 200 (1995) 45-48.
23. [23] Saito, S., Kidd, G.J. and Trapp, B.D. et al., Rat spinal cord neurons contain nitric oxide synthase, Neuroscience, 59 (1994) 447-456.
24. [24] Spike, R.C., Todd, A.J. and Johnston, H.M., Coexistence of NADPH diaphorase with GABA, glycine, and acetylcholine in rat spinal cord, J. Comp. Neurol., 335 (1993) 320-333.
25. [25] Tomlinson, B.E. and Irving, D., The numbers of limb motor neurons in the human lumbosacral cord throughout life, J. Neurol. Sci., 34 (1977) 213-219.
26. [26] Valtschanoff, J.G., Weinberg, R.J. and Rustioni, A., NADPH diaphorase in the spinal cord of rats, J. Comp. Neurol., 321 (1992) 209-222.
27. [27] Wu, W., Expression of nitric oxide synthase (NOS) in injured CNS neurons as shown by histochemistry NADPH-diaphorase, Exp. Neurol., 120 (1993) 1-7.
28. [28] Wu, W., Han, K., Li, L. and Schinco, F.P., Implantation of PNS graft inhibits the induction of neuronal nitric oxide synthase and enhances the survival of spinal motoneurons following root avulsion, Exp. Neurol., 129 (1994) 335-339.
29. [29] Wu, W. and Li, L., Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion, Neurosci. Lett., 153 (1993) 121-124.
30. [30] Wu, W., Li, Y. and Schinco, F.P., Expression of c-jun and neuronal nitric oxide synthase in rat spinal motoneurons following axonal injury, Neurosci. Lett., 179 (1994) 157-161.
31. [31] Wu, W., Liuzzi, F.J. and Schinco, F.P. et al., Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury, Neuroscience, 61 (1994) 719-726.
32. [32] Yokoyama, T., Nonaka, S. and Mori, S., Histochemical properties of intrinsic laryngeal muscles in cats, J. Autonomic Nerv. Syst., 56 (1995) 50-60.
33. [33] Yu, W.-H.A., Nitric oxide synthase in motor neurons after axotomy, J. Histochem. Cytochem., 42 (1994) 451-457.
34. [34] Zhang, L., Kokkonen, G. and Roth, G.S., Identification of neuronal programmed cell death in situ in the striatum of normal adult rat brain and its relationship to neuronal death during aging, Brain Res., 677 (1995) 177-179.