Detection of thrombin in human blood by ex-vivo hirudin

Thrombosis Research

Volumn 84, Issue 4, 1996, Pages 289-294

  Bichler, Johann ^a   Heit, John A ^a   Owen, Whyte G ^a  

^a MAYO CLINIC   (United States)

Author keywords

hirudin; prethrombotic state; thrombin

Indexed keywords

HIRUDIN; THROMBIN;

ADULT; ARTICLE; ASSAY; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOSIS;

ADULT; BLOOD SPECIMEN COLLECTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIRUDINS; HUMANS; MALE; MIDDLE AGED; THROMBIN;

EID: 0030589159     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(96)00189-2     Document Type: Article

References (26)

1. STONE S.R., HOFSTEENGE J. Kinetics of the inhibition of thrombin by hirudin. Biochemistry. 25:1986;4622-4628.
2. BICHLER J., SIEBECK M., MASCHLER R., PELZER H., FRITZ H. Determination of thrombin-hirudin complex with an enzyme-linked immunosorbent assay. Blood Coag Fibrinol. 2:1991;129-133.
3. SCHLAEPPI J.-M. Preparation of monoclonal antibodies to the thrombin/hirudin complex. Thromb Res. 62:1991;1459-1470.
4. ZOLDHELYI P., CHESEBRO J.H., OWEN W.G. Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig. Proc Nat Acad Sci USA. 90:1993;1819-1823.
5. ZOLDHELYI P., BICHLER J., OWEN W.G., GRILL D.E., FUSTER V., MRUK J.S., CHESEBRO J.H. Persistent thrombin generation in humans during specific thrombin inhibition with hirudin. Circulation. 90:1994;2671-2678.
6. BOSCLAIR M.D., PHILIPPOU H., LANE D.A. Thrombogenic mechanisms in the human: fresh insights obtained by immunodiagnostic studies of coagulation markers. Blood Coag Fibrinol. 4:1993;1007-1021.
7. LAU H.K., ROSENBERG J.S., BEELER D.L., ROSENBERG R.D. The isolation and characterization of a specific antibody population against the prothrombin fragments F2 and F1 + 2. J Biol Chem. 254:1979;8751-8761.
8. PELZER H., SCHWARZ A., STUBER W. Determination of human prothrombin activation fragment F1 +2 in plasma with an antibody against a synthetic peptide. Thromb Haemostas. 65:1991;153-159.
9. NOSSEL H.L., YUDELMAN I., CANFIELD R.E., BUTLER V.P., SPANONDISK K., WILNER G.D., QUERESHI G.D. Measurement of fibrinopeptide A in human blood. J Clin Invest. 54:1974;43-53.
10. LAU H.K., ROSENBERG R.D. The isolation and characterization of a specific antibody population directed against the thrombin-antithrombin complex. J Biol Chem. 255:1980;5885.
11. PELZER H., SCHWARZ A., HEIMBURGER N. Determination of human thrombin-antithrombin III complex in plasma with an enzyme-linked immunosorbent assay. Thromb Haemostas. 59:1988;101-106.
12. BAUER K.A., ROSENBERG R.D. Activation markers of coagulation. Bailliere's Clinical Haematology. 7:1994;523-540.
13. GALLISTL S., MUNTEAN W. Thrombin-hirudin complex formation, thrombin-antithrombin II complex formation, and thrombin generation after intrinsic activation of plasma. Thromb Haemostas. 72:1994;387-392.
14. ANDREW M., MITCHELL L., VEGH P., OFOSO F. Thrombin regulation in children differs from adults in the absence and presence of heparin. Thromb Haemostas. 72:1994;836-842.
15. FUHRER G., GALLIMORE M.J., HELLER W., HOFFMEISTER H.E. Aprotinin in cardiopulmonary bypass - effects on Hageman factor (FXII)-kallikrein system and blood loss. Blood Coag Fibrinol. 3:1992;99-104.
16. SHUMAN M.A., MAJERUS P.W. The measurement of thrombin in clotting blood by radioimmunoassay. J Clin Invest. 58:1976;1249-1258.
17. DIETZ-MARTIN J.L., LUST J.A., WITZIG T.E., BANKS P.M., Li C.Y. Unusual presentation of extranodal peripheral T-cell lymphomas with multiple paraneoplastic features. Cancer. 68:1991;834-841.
18. SCHARF R.E., SCHNEIDER W. Relationship of thrombin generation to peripheral blast cell count in patients with acute myeloblastic leukemia (AML). Eur J Haematol. 44:1990;273-276.
19. BAUER K.A., ROSENBERG R.D. Thrombin generation in acute promyelocytic leukemia. Blood. 64:1984;791-796.
20. CATTO A., CARTER A., IRELAND H., BAYSTON T.A., PHILIPPOU H., BARRETT J., LANE D.A., GRANT P.J. Factor V Leiden gene mutation and thrombin generation in relation to the development of acute stroke. Arterioscler Thromb Vasc Biol. 15:1995;783-785.
21. ROEMISCH J., PAQUES E.P. Thrombin-hirudin stability: a comparison with the thrombin-antithrombin III complex. Blood Coag Fibrinol. 2:1991;643-646.
22. BRAUN P.J. Binding properties of hirudin determined by gel filtration and gel electrophoresis. Thromb Res. 59:1990;657-662.
23. TAKANO S., KIMURA S., OHDAMA S., AOKI N. Plasma thrombomodulin in health and diseases. Blood. 76:1990;2024-2029.
24. STOCKER K. Hirudin for diagnostic purposes. Haemostasis. 2((suppl 1)):1991;161-167.
25. MORITA T., IWANAGA S., SUZUKI T. The mechanism of activation of bovine prothrombin by an activator from Echis carinatus venom and characterization of the new active intermediates. J Bichem. 79:1976;1089-1108.
26. BOVILL E.G., TRACY R.P., HAYES T.E., JENNY R.J., BHUSHAN F.H., MANN K.G. Evidence that meizothrombin is an intermediate product in the clotting of whole blood. Arterioscler Thromb Vasc Biol. 15:1995;754-758.