Blockade of voltage-gated outward K+ currents of ramified murine microglia by scorpion peptide toxins

Neuroscience Letters

Volumn 219, Issue 1, 1996, Pages 29-32

  Eder, Claudia ^a   Klee, Rolf ^a   Heinemann, Uwe ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Chalybdotoxin; Kaliotoxin; Noxiustoxin; Potassium current; Ramified microglia

Indexed keywords

CHARYBDOTOXIN; DENDROTOXIN; KALIOTOXIN; NEUROTOXIN; NOXIUSTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED STRAINS; MICROGLIA; POTASSIUM CHANNELS; SCORPION VENOMS;

EID: 0030589070     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13164-5     Document Type: Article

References (12)

1. + channels in T lymphocytes: functional consequences for volume regulation, Proc. Natl. Acad. Sci. USA, 90 (1993) 10036-10040.
2. [2] Eder, C., Fischer, H.G., Hadding, U. and Heinemann, U., Properties of voltage-gated currents of microglia developed using macrophage colony-stimulating factor, Pflügers Arch., 430 (1995) 526-533.
3. [3] Eder, C., Fischer, H.G., Hadding, U. and Heinemann, U., Properties of voltage-gated potassium currents of microglia differentiated with granulocyte/macrophage colony stimulating factor, J. Membr. Biol., 147 (1995) 137-146.
4. + channel profile of microglia at immunologically defined functional states, Neuroscience, 64 (1995) 183-191.
5. [5] Frei, K., Siepl, C., Groscurtll, P., Bodmer, S., Schwerdel, C. and Fontana, A., Antigen presentation and tumor cytotoxicity by interferon-a-treated microglial cells, Eur. J. Immunol., 17 (1987) 1271-1278.
6. + channel gene, Proc. Natl. Acad. Sci. USA, 87 (1990) 9411-9415.
7. [7] Hertz, L., Juurlink, B.H.J., Fosmark, H. and Schousboe, A., Astrocytes in primary cultures. In S.E. Pfeiffer (Ed.), Neuroscience Approached Through Cell Culture, Vol. 1, CRC Press, Boca Raton, FL, 1982. pp. 175-186.
8. [8] Kettenmann, H., Banati, R. and Walz, W., Electrophysiological behavior of microglia, Glia, 7 (1993) 93-101.
9. [9] Korotzer, A.R. and Cotman, C.W., Voltage-gated currents expressed by rat microglia in culture, Glia, 6 (1992) 81-88.
10. [10] McLarnon, J.G., Sawyer, D. and Kim, S.U., Cation and anion unitary ion channel currents in cultured bovine microglia. Brain Res., 693 (1995) 8-20.
11. [11] Norenberg, W., Gebicke-Haerter, P.J. and Illes, P., Voltage-dependent potassium channels in activated rat microglia, J. Physiol., 475 (1994) 15-32.
12. [12] Schmidtmayer, J., Jacobsen, C., Miksch, G. and Sievers, J., Blood monocytes and spleen macrophages differentiate into microglialike cells on monolayers of astrocytes: membrane currents, Glia, 12 (1994) 259-267