17-Beta-estradiol therapy lessens angina in postmenopausal women with syndrome X

Journal of the American College of Cardiology

Volumn 28, Issue 6, 1996, Pages 1500-1505

  Rosano, Giuseppe M C ^a   Peters, Nicholas S ^a   Lefroy, David ^a   Lindsay, David C ^a   Sarrel, Philip M ^a   Collins, Peter ^a   Poole Wilson, Philip A ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; NORETHISTERONE ACETATE; PLACEBO;

ANGINA PECTORIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ESTROGEN THERAPY; FEMALE; HUMAN; ORAL DRUG ADMINISTRATION; POSTMENOPAUSE; PRIORITY JOURNAL; SYNDROME X; THORAX PAIN; TRANSDERMAL DRUG ADMINISTRATION;

CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY, AMBULATORY; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; EXERCISE TEST; FEMALE; HUMANS; MICROVASCULAR ANGINA; POSTMENOPAUSE; PROSPECTIVE STUDIES; THALLIUM RADIOISOTOPES;

EID: 0030588968     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(96)00348-8     Document Type: Article

References (53)

1. 1. Phibbs B, Fleming T, Ewy GA, et al. Frequency of normal coronary arteriograms in three academic medical centers and one community hospital. Am J Cardiol 1988;62:472-4.
2. 2. Likoff W, Segal BL, Kasparian H. Paradox of normal selective coronary arteriograms in patients considered to have unmistakable coronary heart disease. N Engl J Med 1967;276:1063-6.
3. 3. Proudfit WL, Shirley EK, Jones FM. Selective coronary arteriography: correlation with clinical findings in 1000 cases. Circulation 1986;33:901-10.
4. 4. Kemp HG Jr, Vokonas PS, Cohn PF, Gorlin R. The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience. Am J Med 1973;54:735-42.
5. 5. Kemp HG Jr. Left ventricular function in patients with anginal syndrome and normal coronary arteriograms. Am J Cardiol 1973;32:375-6.
6. 6. Kemp HG, Kronmal RA, Vlietstra RE, Frye RL. Seven year survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol 1986;7:479-83.
7. 7. Maseri A, Crea F, Kaski JC, Crake T. Mechanisms of angina pectoris in syndrome X. J Am Coll Cardiol 1991;17:499-506.
8. 8. Cannon RO, Epstein SE. "Microvascular angina" as a cause of chest pain with angiographically normal coronary arteries. Am J Cardiol 1988;61:1338-43.
9. 9. Rosano GMC, Lindsay DC, Poole-Wilson PA. Syndrome X: an hypothesis for cardiac pain without ischaemia. Cardiologia 1991;36:885-95.
10. 10. Opherk D, Zebe H, Weihe E, et al. Reduced coronary dilatory capacity and ultrastructural changes of the myocardium in patients with angina pectoris but normal coronary arteriograms. Circulation 1981;63:817-25.
11. 11. Romeo F, Gaspardone A, Ciavolella M, Gioffrè P, Reale A. Verapamil versus acebutolol for syndrome X. Am J Cardiol 1988;62:312-3.
12. 12. Turiel M, Galassi AR, Glazier JJ, Kaski JC, Maseri A. Pain threshold and tolerance in women with syndrome X and women with stable angina pectoris. Am J Cardiol 1987;60:503-7.
13. 13. Galassi AR, Kaski JC, Crea F, et al. Heart rate response during exercise testing and ambulatory ECG monitoring in patients with syndrome X. Am Heart J 1991;122:458-63.
14. 14. Kaski JC, Rosano GMC, Collins P, Nihoyannopoulos P, Maseri A, Poole-Wilson PA. Cardiac syndrome X: clinical characteristics and left ventricular function. Long-term follow-up study. J Am Coll Cardiol 1995;25:807-14.
15. 15. Volterrani M, Rosano GMC, Coats A, Beale C, Collins P. Estrogen acutely increases peripheral blood flow in postmenopausal women. Am J Med 1995;99:119-22.
16. 16. Ganger KF, Vyas S, Whitehead M, Crook D, Meire H, Campbell S. Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause. Lancet 1991;338:839-42.
17. 17. Collins P, Rosano GMC, Sarrel PM, et al. Estradiol-17β attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease. Circulation 1995;92:24-30.
18. 18. Ginsburg J, Hardiman P, O'Reilly B. Peripheral blood flow in menopausal women who have hot flushes and in those who do not. BMJ 1989;298: 1488-90.
19. 19. Sarrel PM, Lindsay DC, Rosano GMC, Poole-Wilson PA. Angina and normal coronary arteries in women. Gynecologic findings. Am J Obstet Gynecol 1992;167:467-71.
20. 20. Poole-Wilson PA. Potassium and the heart. Clin Endocrinol Metab 1984; 13:249-68.
21. 21. Good WR, Powers MS, Campbell P, Schenkel L. A new transdermal delivery system for estradiol. J Controlled Release 1985;2:89-97.
22. 22. Crea F, Pupita G, Galassi AR, et al. Role of adenosine in pathogenesis of anginal pain. Circulation 1990;81:164-72.
23. 23. Rosano GMC, Sarrel PM, Poole-Wilson PA, Collins P. Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease. Lancet 1993;342:133-6.
24. 24. Jones B, Kenward MG: Design and Analysis of Crossover Trials. London: Chapman & Hall, 1989.
25. 25. Schofield PM, Bennett DH, Whorwell PJ, et al. Exertional gastrooesophageal reflux: a mechanism for symptoms in patients with angina pectoris and normal coronary angiograms. Br Med J 1987;294:1459-61.
26. 26. Richter JE, Bradley LA. Chest pain with normal coronary arteries: another perspective. Dig Dis Sci 1990;35:1441-4.
27. 27. Bass C, Chambers JB, Kiff P, et al. Panic anxiety and hyperventilation in patients with chest pain: a controlled study. Q J Med 1988;260:949-59.
28. 28. Greenberg MA, Grose RM, Neuburger N, Silverman R, Strain JE, Cohen MV. Impaired coronary vasodilator responsiveness as a cause of lactate production during pacing-induced ischemia in patients with angina pectoris and normal coronary arteries. J Am Coll Cardiol 1987;9:743-51.
29. 29. Jackson G, Atkinson L, Clark M, Crook B, Armstrong P, Oram S. Diagnosis of coronary artery disease by estimation of coronary sinus lactate. Br Heart J 1978;40:979-83.
30. 30. Crake T, Canepa-Anson R, Shapiro L, Poole-Wilson PA. Continuous recording of coronary sinus oxygen saturation during atrial pacing in patients with coronary artery disease or with syndrome X. Br Heart J 1988;59:31-8.
31. 31. Meller J, Goldsmith SJ, Rudin A, et al. Spectrum of exercise thallium-201 myocardial perfusion imaging in patients with chest pain and normal coronary angiograms. Am J Cardiol 1979;43:717-23.
32. 32. Levy RD, Shapiro LM, Wright C, Mockus L, Fox KM. Syndrome X: the haemodynamic significance of ST segment depression. Br Heart J 1986;56: 353-7.
33. 33. Camici PG, Marraccini P, Lorenzoni R, et al. Coronary hemodynamics and myocardial metabolism in patients with syndrome X: response to pacing stress. J Am Coll Cardiol 1991;17:1461-70.
34. 34. Henein MY, Rosano GMC, Underwood R, Poole-Wilson PA, Gibson DG. Relations between resting ventricular long axis function, the electrocardiogram, and myocardial perfusion imaging in syndrome X. Br Heart J 1994;71:541-7.
35. 35. Cannon RO III, Quyyumi AA, Mincemoyer R, et al. Imipramine in patients with chest pain despite normal coronary angiograms. N Engl J Med 1994;330:1411-7.
36. 36. Rosano GMC, Collins P, Kaski JC, Lindsay DC, Sarrel PM, Poole-Wilson PA. Syndrome X in women is associated with estrogen deficiency. Eur Heart J 1995;16:610-4.
37. 37. Collins P, Rosano GMC, Jiang C, Lindsay D, Sarrel PM, Poole-Wilson PA. Hypothesis: cardiovascular protection by oestrogen - a calcium antagonist effect? Lancet 1993;341:1264-5.
38. 38. Chester AH, Jiang C, Borland JA, Yacoub MH, Collins P. Estrogen relaxes human epicardial coronary arteries through non-endothelium-dependent mechanisms. Coron Artery Dis 1995;6:417-22.
39. 39. Jiang C, Sarrel PM, Lindsay DC, Poole-Wilson PA, Collins P. Endothelium-independent relaxation of rabbit coronary artery by 17β-oestradiol in vitro. Br J Pharmacol 1991;104:1033-7.
40. 40. Gilligan DM, Quyyumi AA, Cannon RO III. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 1994;89:2545-51.
41. 41. Reis SE, Gloth ST, Blumenthal RS, et al. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 1994;89:52-60.
42. 42. Williams JK, Adams MR, Herrington DM, Clarkson TB. Short-term administration of estrogen and vascular responses of atherosclerotic coronary arteries. J Am Coll Cardiol 1992;20:452-7.
43. 43. Rees MC, Barlow DH. Absence of sustained reflex vasoconstriction in women with menopausal flushes. Hum Reprod 1988;3:823-5.
44. 44. Magness RR, Rosenfeld CR. Local and systemic estradiol-17 beta: effects on uterine and systemic vasodilation. Am J Physiol 1989;256:E536-42.
45. 45. Mügge A, Riedel M, Barton M, Kuhn M, Lichten PR. Endothelium independent relaxation of human coronary arteries by 17-beta-oestradiol in vitro. Cardiovasc Res 1993;27:1939-42.
46. 46. Shapiro LM, Crake T, Poole-Wilson PA. Is altered cardiac sensation responsible for chest pain in patients with normal coronary arteries? Clinical observation during cardiac catheterisation. BMJ 1988;296:170-1.
47. 47. Cannon RO III, Quyyumi AA, Schenke WH, et al. Abnormal cardiac sensitivity in patients with chest pain and normal coronary arteries. J Am Coll Cardiol 1990;16:1359-66.
48. 48. Lagerqvist B, Sylven C, Waldenström A. Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary arteriograms. Br Heart J 1992;68:282-5.
49. 49. Emdin M, Picano E, Lattanzi F, L'Abbate A. Improved exercise capacity with acute aminophylline administration in patients with syndrome X. J Am Coll Cardiol 1989;14:1450-3.
50. 50. Mogil JS, Sternberg WF, Kest B, Marek P, Liebeskind JC. Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain 1993;53:17-25.
51. 51. Dart AM, Davies HA, Dalal J, Ruttley M, Henderson AH. 'Angina' and normal coronary arteriograms: a follow-up study. Eur Heart J 1980; 1:97-100.
52. 52. Koligian KB, Stormshak F. Progesterone inhibition of estrogen receptor replenishment in ovine endometrium. Biol Reprod 1977;17:412-6.
53. 53. Tseng L, Gurpide E. Effects of progestins on estradiol receptor levels in human endometrium. J Clin Endocrinol Metab 1975;41:402-4.