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Volumn 157, Issue 10, 1996, Pages 4297-4308

Impaired Signaling in Alloantigen-Specific CD8+ T Cells Tolerized in Vivo: Employing a Model of Ld-Specific TCR Transgenic Mice Transplanted with Allogenic Hearts under the Cover of a Short-Term Rapamycin Treatment

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; FYN PROTEIN, MOUSE; H2 ANTIGEN; HISTOCOMPATIBILITY ANTIGEN H 2D(B); HISTOCOMPATIBILITY ANTIGEN H-2D(B); IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; ONCOPROTEIN; POLYENE; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; RAPAMYCIN;

EID: 0030588676     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (50)
  • 1
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina, C., A. Kudelski, and S. N. Sehgal. 1975. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28:721.
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 721
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 2
    • 0024472603 scopus 로고
    • A receptor for the immunosuppressant FK506 is a cis-trans peptidylprolyl isomerase
    • Harding, M. W., A. Galat, D. E. Uehling, and S. L. Schreiber. 1989. A receptor for the immunosuppressant FK506 is a cis-trans peptidylprolyl isomerase. Nature 341:758.
    • (1989) Nature , vol.341 , pp. 758
    • Harding, M.W.1    Galat, A.2    Uehling, D.E.3    Schreiber, S.L.4
  • 3
    • 0028355053 scopus 로고
    • Rapamycin-induced long-term allograft survival depends on persistence of alloantigen
    • Chen, H., H. Luo, P. Daloze, D. Xu, and J. Wu. 1994. Rapamycin-induced long-term allograft survival depends on persistence of alloantigen. J. Immunol. 152: 3107.
    • (1994) J. Immunol. , vol.152 , pp. 3107
    • Chen, H.1    Luo, H.2    Daloze, P.3    Xu, D.4    Wu, J.5
  • 5
    • 0021269262 scopus 로고
    • Suppressor T cells in rats with prolonged cardiac allograft survival after treatment with cyclosporine
    • Hall, B. M., M. E. Jelbart, and S. E. Dorsch. 1984. Suppressor T cells in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Transplantation 37:595.
    • (1984) Transplantation , vol.37 , pp. 595
    • Hall, B.M.1    Jelbart, M.E.2    Dorsch, S.E.3
  • 6
    • 0025963172 scopus 로고    scopus 로고
    • Cyclosporine induces reduction of antigen-specific T cytotoxic clones in rats transplanted with heart allografts
    • Miyagawa, S., J. G. Lawen, S. M. Stepkowski, and B. D. Kahan. Cyclosporine induces reduction of antigen-specific T cytotoxic clones in rats transplanted with heart allografts. Transplant. Proc. 23:485.
    • Transplant. Proc. , vol.23 , pp. 485
    • Miyagawa, S.1    Lawen, J.G.2    Stepkowski, S.M.3    Kahan, B.D.4
  • 7
    • 0023568088 scopus 로고
    • Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats
    • Ochiai, T., K. Nakajima, M. Nagata, S. Hori, T. Asano, and K. Isono. 1987. Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation 44:734.
    • (1987) Transplantation , vol.44 , pp. 734
    • Ochiai, T.1    Nakajima, K.2    Nagata, M.3    Hori, S.4    Asano, T.5    Isono, K.6
  • 8
    • 0027403136 scopus 로고
    • Specific tolerance to neural allografts induced with an antibody to the interleukin 2 receptor
    • Wood, M. J., D. J. Sloan, M. J. Dallman, and H. M. Charlton. 1993. Specific tolerance to neural allografts induced with an antibody to the interleukin 2 receptor. J. Exp. Med. 177:597.
    • (1993) J. Exp. Med. , vol.177 , pp. 597
    • Wood, M.J.1    Sloan, D.J.2    Dallman, M.J.3    Charlton, H.M.4
  • 9
    • 0026577832 scopus 로고
    • Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8
    • Chen, Z., S. Cobbold, S. Metcalfe, and H. Waldmann. 1992. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. Eur. J. Immunol. 22:805.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 805
    • Chen, Z.1    Cobbold, S.2    Metcalfe, S.3    Waldmann, H.4
  • 10
    • 0026579147 scopus 로고
    • Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1
    • Isobe, M., H. Yagita, K. Okumura, and A. Ihara. 1992. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255:1125.
    • (1992) Science , vol.255 , pp. 1125
    • Isobe, M.1    Yagita, H.2    Okumura, K.3    Ihara, A.4
  • 12
    • 0026701534 scopus 로고
    • Maintenance of in vivo tolerance by persistence of antigen
    • Ramsdell, F., and B. J. Fowlkes. 1992. Maintenance of in vivo tolerance by persistence of antigen. Science 257:1130.
    • (1992) Science , vol.257 , pp. 1130
    • Ramsdell, F.1    Fowlkes, B.J.2
  • 13
    • 0026708967 scopus 로고
    • Induction of antigen-specific tolerance by cyclosporin A
    • Stitz, L. 1992. Induction of antigen-specific tolerance by cyclosporin A. Eur. J. Immunol 22:1995.
    • (1992) Eur. J. Immunol , vol.22 , pp. 1995
    • Stitz, L.1
  • 14
    • 0023228892 scopus 로고
    • Alloantigen persistence in induction and maintenance of transplantation tolerance
    • Morecki, S., B. Leshem, A. Eid, and S. Slavin. 1987. Alloantigen persistence in induction and maintenance of transplantation tolerance. J. Exp. Med. 165:1468.
    • (1987) J. Exp. Med. , vol.165 , pp. 1468
    • Morecki, S.1    Leshem, B.2    Eid, A.3    Slavin, S.4
  • 16
    • 0023785318 scopus 로고
    • Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
    • Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271.
    • (1988) Nature , vol.335 , pp. 271
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 20
    • 0015591234 scopus 로고
    • Heart transplantation in congenic strains of mice
    • Corry, R. J., H. J. Winn, and P. S. Russell. 1973. Heart transplantation in congenic strains of mice. Transplant. Proc. 5:733.
    • (1973) Transplant. Proc. , vol.5 , pp. 733
    • Corry, R.J.1    Winn, H.J.2    Russell, P.S.3
  • 21
    • 0028267342 scopus 로고
    • The effect of rapamycin on T cell development in mice
    • Luo, H., W. Duguid, H. Chen, M. Maheu, and J. Wu. 1994. The effect of rapamycin on T cell development in mice. Eur. J. Immunol. 24:692.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 692
    • Luo, H.1    Duguid, W.2    Chen, H.3    Maheu, M.4    Wu, J.5
  • 23
    • 0019468220 scopus 로고
    • Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis
    • Taswell, C. 1981. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 126:1614.
    • (1981) J. Immunol. , vol.126 , pp. 1614
    • Taswell, C.1
  • 25
    • 0028871661 scopus 로고
    • Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: Expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells
    • Aguila, H. L., R. J. Hershberger, and I. L. Weissman. 1995. Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells. Proc. Natl. Acad. Sci. USA 92:10192.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10192
    • Aguila, H.L.1    Hershberger, R.J.2    Weissman, I.L.3
  • 26
    • 85025352713 scopus 로고
    • Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides
    • Morris, R. E. 1992. Rapamycins: antifungal, antitumor, antiproliferative, and immunosuppressive macrolides. Transplant. Rev. 6:39.
    • (1992) Transplant. Rev. , vol.6 , pp. 39
    • Morris, R.E.1
  • 29
    • 0027958565 scopus 로고
    • Anergic T-lymphocyte clones have altered inositol phosphate, calcium and tyrosine kinase signaling pathways
    • Gajewski, T. F., D. Qian, P. Fields, and F. W. Fitch. 1994. Anergic T-lymphocyte clones have altered inositol phosphate, calcium and tyrosine kinase signaling pathways. Proc. Natl. Acad. Sci. USA 91:38.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 38
    • Gajewski, T.F.1    Qian, D.2    Fields, P.3    Fitch, F.W.4
  • 30
    • 0026047598 scopus 로고
    • Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice
    • Blackman, M. A., T. H. Finkel, J. Kappler, J. Cambier, and P. Marrack. 1991. Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice. Proc. Natl. Acad. Sci. USA 88:6682.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6682
    • Blackman, M.A.1    Finkel, T.H.2    Kappler, J.3    Cambier, J.4    Marrack, P.5
  • 31
    • 0028057792 scopus 로고
    • The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor-mediated signal transduction pathway
    • Isakov, N., R. L. Wange, and L. E. Samelson. 1994. The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor-mediated signal transduction pathway. J. Leukocyte Biol. 55: 265.
    • (1994) J. Leukocyte Biol. , vol.55 , pp. 265
    • Isakov, N.1    Wange, R.L.2    Samelson, L.E.3
  • 32
    • 0026448369 scopus 로고
    • Tyrosine kinases and tyrosine-based activation motifs: Current research on activation via the T cell antigen receptor
    • Samelson, L. E., and R. D. Klausner. 1992. Tyrosine kinases and tyrosine-based activation motifs: current research on activation via the T cell antigen receptor. J. Biol. Chem. 267:24913.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24913
    • Samelson, L.E.1    Klausner, R.D.2
  • 33
    • 0027056895 scopus 로고
    • Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
    • Mizoguchi, H., J. J. O'Shea, D. L. Longo, C. M. Loeffler, D. W. McVicar, and A. C. Ochoa. 1992. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258:1795.
    • (1992) Science , vol.258 , pp. 1795
    • Mizoguchi, H.1    O'Shea, J.J.2    Longo, D.L.3    Loeffler, C.M.4    McVicar, D.W.5    Ochoa, A.C.6
  • 34
    • 0028045991 scopus 로고
    • Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors
    • Salvadori, S., B. Bansbacher, A. M. Pizzimenti, and K. S. Zier. 1994. Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors. J. Immunol. 153:5176.
    • (1994) J. Immunol. , vol.153 , pp. 5176
    • Salvadori, S.1    Bansbacher, B.2    Pizzimenti, A.M.3    Zier, K.S.4
  • 35
    • 0026600993 scopus 로고
    • Src-related protein tyrosine kinases and T-cell receptor signaling: Tyrosine phosphorylation pathways
    • Veillette, A., and D. Davidson. 1992. Src-related protein tyrosine kinases and T-cell receptor signaling: tyrosine phosphorylation pathways. Trends Genet. 8:61.
    • (1992) Trends Genet. , vol.8 , pp. 61
    • Veillette, A.1    Davidson, D.2
  • 36
    • 0028921624 scopus 로고
    • Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance
    • Alferink, J., B. Schittek, G. Schonrich, G. J. Hammerling, and B. Arnold. 1995. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int. Immunol. 7:331.
    • (1995) Int. Immunol. , vol.7 , pp. 331
    • Alferink, J.1    Schittek, B.2    Schonrich, G.3    Hammerling, G.J.4    Arnold, B.5
  • 37
    • 2342538750 scopus 로고
    • Antigen release from the transplanted dog kidney
    • Nathan, P. 1964. Antigen release from the transplanted dog kidney. Ann. NY Acad. Sci. 120:458.
    • (1964) Ann. NY Acad. Sci. , vol.120 , pp. 458
    • Nathan, P.1
  • 38
    • 0015424429 scopus 로고
    • Endothelial cell stimulation of allogeneic lymphocytes
    • Vetto, R. M., and D. R. Burger. 1972. Endothelial cell stimulation of allogeneic lymphocytes. Transplantation 14:652.
    • (1972) Transplantation , vol.14 , pp. 652
    • Vetto, R.M.1    Burger, D.R.2
  • 39
    • 0006489924 scopus 로고
    • The role of lymphocytes in the sensitization of rats to renal homografts
    • Strober, S., and J. L. Gowans. 1965. The role of lymphocytes in the sensitization of rats to renal homografts. J. Exp. Med. 122:347.
    • (1965) J. Exp. Med. , vol.122 , pp. 347
    • Strober, S.1    Gowans, J.L.2
  • 40
    • 0019986126 scopus 로고
    • Redistribution of renal allograft-responding leukocytes during rejection
    • Nemlander, A., A. Soots, E. Von Willebrand, B. Husberg, and P. Hayry. 1982. Redistribution of renal allograft-responding leukocytes during rejection. J. Exp. Med 156:1087.
    • (1982) J. Exp. Med , vol.156 , pp. 1087
    • Nemlander, A.1    Soots, A.2    Von Willebrand, E.3    Husberg, B.4    Hayry, P.5
  • 41
    • 0026773086 scopus 로고
    • Alloantigenicity of human endothelial cells. I. Frequency and phenotype of human T helper lymphocytes that can react to allogeneic endothelial cells
    • Adams, P. W., H. S. Lee, W. J. Waldman, D. D. Sedmak, C. J. Morgan, J. S. Ward, and C. G. Orosz. 1982. Alloantigenicity of human endothelial cells. I. Frequency and phenotype of human T helper lymphocytes that can react to allogeneic endothelial cells. J. Immunol. 148:3753.
    • (1982) J. Immunol. , vol.148 , pp. 3753
    • Adams, P.W.1    Lee, H.S.2    Waldman, W.J.3    Sedmak, D.D.4    Morgan, C.J.5    Ward, J.S.6    Orosz, C.G.7
  • 42
    • 0029103149 scopus 로고
    • Pretreatment of donors and grafts with rapamycin: The effect on graft survival and the tissue drug retention
    • Chen, H., S. Sehgal, P. Daloze, and J. Wu. 1995. Pretreatment of donors and grafts with rapamycin: the effect on graft survival and the tissue drug retention. Clin. Immunol. Immunopathol. 76:321.
    • (1995) Clin. Immunol. Immunopathol. , vol.76 , pp. 321
    • Chen, H.1    Sehgal, S.2    Daloze, P.3    Wu, J.4
  • 43
    • 0029014107 scopus 로고
    • Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat
    • Chen, H., D. Xu, S. Qi, J. Wu, H. Luo, and P. Daloze. 1995. Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat. Transplantation 59:1084.
    • (1995) Transplantation , vol.59 , pp. 1084
    • Chen, H.1    Xu, D.2    Qi, S.3    Wu, J.4    Luo, H.5    Daloze, P.6
  • 44
    • 0023622463 scopus 로고
    • Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells
    • Witmer-Pack, M. D., W. Olivier, J. Valinsky, G. Schuler, and R. M. Steinman. 1987. Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J. Exp. Med. 166:1484.
    • (1987) J. Exp. Med. , vol.166 , pp. 1484
    • Witmer-Pack, M.D.1    Olivier, W.2    Valinsky, J.3    Schuler, G.4    Steinman, R.M.5
  • 45
    • 0023867476 scopus 로고
    • Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells
    • Heufler, C., F. Koch, and G. Schuler. 1988. Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J. Exp. Med. 167:700.
    • (1988) J. Exp. Med. , vol.167 , pp. 700
    • Heufler, C.1    Koch, F.2    Schuler, G.3
  • 46
    • 0020323420 scopus 로고
    • Demonstration of active tolerance in maintenance of established islet of Langerhans allografts
    • Faustmann, D., V. Hauptfeld, P. Lacy, and J. Davie. 1982. Demonstration of active tolerance in maintenance of established islet of Langerhans allografts. Proc. Nat. Acad. Sci. USA 79:4153.
    • (1982) Proc. Nat. Acad. Sci. USA , vol.79 , pp. 4153
    • Faustmann, D.1    Hauptfeld, V.2    Lacy, P.3    Davie, J.4
  • 47
    • 0025064312 scopus 로고
    • Migration of dendritic leukocytes from cardiac allografts into host spleens: A novel pathway for initiation of rejection
    • Larsen, C. P., P. J. Morris, and J. M. Austyn. 1990. Migration of dendritic leukocytes from cardiac allografts into host spleens: a novel pathway for initiation of rejection. J. Exp. Med. 171:307.
    • (1990) J. Exp. Med. , vol.171 , pp. 307
    • Larsen, C.P.1    Morris, P.J.2    Austyn, J.M.3
  • 48
    • 0027532184 scopus 로고
    • Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
    • Rocha, B., C. Tanchot, and H. Von Boehmer. 1993. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177:1517.
    • (1993) J. Exp. Med. , vol.177 , pp. 1517
    • Rocha, B.1    Tanchot, C.2    Von Boehmer, H.3
  • 49
    • 0028966159 scopus 로고
    • Sequential protocol biopsies in renal transplant patients. Clinico-pathological correlations using the Banff schema
    • Rush, D. N., J. R. Jeffery, and J. Gough. 1995. Sequential protocol biopsies in renal transplant patients. Clinico-pathological correlations using the Banff schema. Transplantation 59:511.
    • (1995) Transplantation , vol.59 , pp. 511
    • Rush, D.N.1    Jeffery, J.R.2    Gough, J.3


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