Tyrosine Phosphorylation and Recruitment of ZAP-70 to the CD3-TCR Complex Are Defective after CD2 Stimulation

Journal of Immunology

Volumn 157, Issue 10, 1996, Pages 4322-4332

  Hubert, Pascale ^a,b   Lang, Valérie ^a   Debré, Patrice ^a   Bismuth, Georges ^a  

^a Laboratoire d'Immunologie Cellulaire et Tissulaire CNRS URA 625   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; ENZYME PRECURSOR; FYN PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; ONCOPROTEIN; PHOSPHOLIPASE C; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; ZAP70 PROTEIN, HUMAN;

ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

ANTIGENS, CD2; ENZYME PRECURSORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); PHOSPHOLIPASE C; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0030588540     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Collins, T. L., P. D. Kassner, B. E. Bierer, and S. J. Burakoff. 1994. Adhesion receptors in lymphocyte activation. Curr. Opin. Immunol. 6:385.
2. Krensky, A. M., F. Sanchez-Madrid, E. Robbins, J. A. Nagy, T. A. Springer, and S. J. Burakoff. 1983. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. J. Immunol. 131:611.
3. Selvaraj, P., M. L. Plunkett, M. Dustin, M. E. Sanders, S. Shaw, and T. A. Springer. 1987. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature 326:400.
4. Hahn, W, C., E. Menu, A. L. M. Bothwell, P. J. Sims, and B. E. Bierer. 1992. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science 256:1805.
5. Bell, G. M., and J. B. Imboden. 1995. CD2 and the regulation of T cell anergy. J. Immunol. 155:2805.
6. Meuer, S. C., R. E. Hussey, M. Fabbi, D. Fox, O. Acuto, K. A. Fitzgerald, J. C. Hodgdon, J. P. Protentis, S. F. Schlossman, and E. L. Reinherz. 1984. An alternative pathway of T-cell activation: a functional role for the 50-kDa T11 sheep erythrocyte receptor protein. Cell 36:897.
7. Boussiotis, V. A., G. J. Freeman, J. D. Griffin, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1994. CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J. Exp. Med. 180:1665.
8. Miller, G. T., P. S. Hochman, W. Meier, R. Tizard, S. A. Bixler, M. D. Rosa, and B. P. Wallner. 1993. Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses. J. Exp. Med. 178:211.
9. + T cells is induced by some combinations of anti-CD2 mAb. J. Immunol. 151:3547.
10. Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
11. Mustelin, T. 1994. T cell antigen receptor signaling: three families of tyrosine kinases and a phosphatase. Cell 1:351.
12. Cambier, J. C. 1995. New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL). Immunol. Today 16:110.
13. Ley, S. C., A. A. Davies, B. Druker, and M. J. Crumpton. 1991. The T cell receptor/CD3 complex and CD2 stimulate the tyrosine phosphorylation of indistinguishable patterns of polypeptides in the human T leukemic cell line Jurkat. Eur. J. Immunol. 21:2203.
14. Pantaleo, G., D. Olive, A. Poggi, W. J. Kozumbo, L. Moretta, and A. Moretta. 1987 Transmembrane signalling via the T11-dependent pathway of human T cell activation: evidence for the involvement of 1,2-diacylglycerol and inositol phosphates. Eur. J. Immunol. 17:55.
15. Alcover, A., C. Alberini, O. Acuto, L. K. Clayton, C. Transy, G. C. Spagnoli, P. Moingeon, P. Lopez, and E. L. Reinherz. 1988. Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes. EMBO J. 7:1973.
16. Bockenstedt, L. K., M. A. Goldsmith, M. Dustin, D. Olive, T. A. Springer, and A. Weiss. 1988. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J. Immunol. 141:1904.
17. Moingeon, P., J. L. Lucich, D. J. McConkey, F. Letourneur, B. Malissen, J. Kochan, H-C. Chang, H.-R. Rodewald, and E. L Reinherz. 1992. CD3ζ dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc. Natl. Acad. Sci. USA 89:1492.
18. Howard, F. D., P. Moingeon, U. Moebius, D. J. McConkey, B. Yandava, T. E. Gennert, and E. L. Reinherz. 1992. The CD3ζ cytoplasmic domain mediates CD2-induced T cell activation. J. Exp. Med. 176:139.
19. Kanner, S. B., N. K. Damle, J. Blake, A. Aruffo, and J. A. Ledbetter. 1992. CD2/LFA3 ligation induces phospholipase-Cγl tyrosine phosphorylation and regulates CD3 signaling. J. Immunol. 148:2023.
20. Ohno, H., C. Ushiyama, M. Taniguchi, R. N. Germain, and T. Saito. 1991. CD2 can mediate TCR/CD3-independent T cell activation. J. Immunol. 146:3742.
21. - thymocytes. Proc. Natl. Acad. Sci. USA 89:8706.
22. low" human thymocyte populations can readily be triggered via the CD2 and/or CD28 activation pathways whereas the CD3 pathway remains nonfunctional. Proc. Natl. Acad. Sci. USA 144:1202.
23. Hubert, P., P. Debré, L. Boumsell, and G. Bismuth. 1993. Tyrosine phosphorylation and association with phospholipase Cγ-1 of the GAP-associated 62-kDa protein following CD2 stimulation of Jurkat T cell. J. Exp. Med. 178:1587.
24. Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the Lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585.
25. Bernard, A., C. Gelin, B. Raynal, D. Pham, C. Gosse, and L. Boumsell. 1982. Phenomenon of human T cells rosetting with sheep erythrocytes analysed with monoclonal antibodies. J. Exp. Med. 155:1317.
26. Straus, D. B., and A. Weiss. 1993. The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation. J. Exp. Med. 178:1523.
27. Bismuth, G., I. Theodorou, H. Gouy, S. Le Gouvello, A. Bernard, and P. Debré. 1988. Cyclic AMP-mediated alteration of the CD2 activation process in human T lymphocytes: preferential inhibition of the phosphoinositide cycle-related transduction pathway. Eur. J. Immunol. 18:1351.
28. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440.
29. Howe, L. R., and A. Weiss. 1995. Multiple kinases mediate T-cell-receptor signaling. Trends Biochem. Sci. 20:59.
30. Neumeister, E. N., Y. Zhu, S. Richard, C. Terhorst, A. C. Chan, and A. Shaw. 1995. Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. 15:3171.
31. Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3∈ from activated Jurkat T cells. J. Biol. Chem. 268:19797.
32. lck interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp. Med. 179:1163.
33. lck/CD4 to the activated T cell receptor/CD3/ζ complex. J Exp. Med. 181:1997.
34. Kong, G-H., J-Y. Bu, T. Kurosaki, A. S. Shaw, and A, C. Chan. 1995. Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase. Cell 2:485.
35. Gelfand, E. W., K. Weinberg, B. D. Mazer, T. A. Kadlecek, and A. Weiss. 1995. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. J. Exp. Med. 182:1057.
36. Iwashima, M., B. A. Irving, N. S. C. van Oers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136.
37. lck. Eur. J. Immunol. 22:2915.
38. lck. J. Biol. Chem. 268:27420.
39. fyn following T cell antigen receptor cross-linking. J. Biol. Chem. 267:18259.
40. Beyers, A. D., L. L. Spruyt, and A. F. Williams. 1992. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA 89:2945.
41. Jin, Y-J., D. R. Kaplan, M. White, G. C. Spagnoli, T. M. Roberts, and E. L. Reinherz. 1990. Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. J. Immunol. 144:647.
42. Hatada, M. H., X. Lu, E. R. Laird, J. Green, J. P. Morgenstern, M. Lou, C. S. Marr, T. B. Phillips, M. K. Ram, K. Theriault, M. J. Zoller, and J. L. Karas. 1995. Molecular basis for interaction of the tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377:32.
43. Elder, M. E., D. Lin, J. Clever, A. C. Chan, T. J. Hope, A. Weiss, and T. G. Parslow. 1994. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264:1596.
44. Chan, A. C., T. A. Kadlecek, M. E. Elder, A. H. Filipovitch, W-L. Kuo, M. Iwashima, T. G. Parslow, and A. Weiss. 1994. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency Science 264: 1599.
45. + thymic selection in humans lacking ZAP-70 kinase. Cell 76:947.
46. Weber, J. R., G. M. Bell, M. Y. Han, T. Pawson, and J. B. Imboden. 1992. Association of the tyrosine kinase LCK with phospholipase C-γl after stimulation of the T cell antigen receptor. J. Exp. Med. 176:373.
47. Neet, K., and T. Hunter. 1995. The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src. Mol. Cell. Biol. 15:4908.
48. Schraven, B., M. Wild, H. Kirchgessner, B. Siebert, R. Wallich, S. Henning, Y. Samstag, and S. C. Meuer. 1993. Alteration of CD2 association with T cell receptor signaling molecules in CD2 unresponsive human T lymphocytes. Eur. J. Immunol. 23:119.
49. Bell, G. M., J. B. Bolen, and J. B. Imboden. 1992. Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Mol. Cell. Biol. 12:5548.
50. lck binds to proline-rich sequences in the cytoplasmic domain of CD2. J. Exp. Med. 183:169.
51. Wegener, A-M. K., F. Letourneur, A. Hoeveler, T. Brocker, F. Luton, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68:83.
52. Yssel, H., J. P. Aubry, R. de Waal Malefijt, J. E. de Vries, and H. Spits. 1987. Regulation by anti-CD2 monoclonal antibody of the activation of a human T cell clone induced by anti-CD3 or anti-T cell receptor antibodies. J. Immunol. 139: 2850.
53. Ledbetter, J. A., J. P. Deans, A. Aruffo, L. S. Grosmaire, S. B. Kanner, J. B. Holen, and G. L. Schieven. 1993. CD4, CD8 and the role of CD45 in T-cell activation. Curr. Opin. Immunol. 5:334.
54. Schraven, B., H. Kirchgessner, K. Rensch, and S. C. Meuer. 1994. Analysis of the signalling panel mAb for coprecipitation of CD45 phosphatase activity: evidence that the CD98-4F2 antigen is associated with CD45 in activated human T lymphocytes and the leukaemic T-cell line HPB-ALL. In Leucocyte Typing V: White Cell Differentiation Antigens. S. Schlossman, L. Boumsell, W. Gilks, J. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T. Tedder and R. Todd, eds. Oxford University Press, Oxford, p. 314.
55. Moran, M. F., C. A. Koch, D. Anderson, C. Ellis, L. England, G. S. Martin, and T. Pawson. 1990. src homology region 2 domains direct protein-protein interactions in signal transduction. Proc. Natl. Acad. Sci. USA 87:8622.
56. + T cells. Science 271:1272.
57. + T cells. Science 271:1276.
58. Nunès, J. A., A. Truneh, D. Olive, and D. A. Cantrell. 1996. Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules. J. Biol. Chem. 271:1591.