Structure-function relations of antithrombin III-heparin interactions as assessed by biophysical and biological assays and molecular modeling of peptide-pentasaccharide-docked complexes

Archives of Biochemistry and Biophysics

Volumn 334, Issue 2, 1996, Pages 206-213

  Tyler Cross, Ruth ^a   Sobel, Michael ^a   McAdory, Louis E ^a   Harris, Robert B ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Commonwealth Biotechnologies Inc ^*  (United States)

Author keywords

antithrombin III; binding domains; heparin; isothermal titration calorimetry; molecular modeling; pentasaccharide; synthetic peptides

Indexed keywords

ANTITHROMBIN III; HEPARIN; PENTASACCHARIDE; PEPTIDE;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOASSAY; BIOPHYSICS; CALORIMETRY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

EID: 0030588177     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1996.0448     Document Type: Article

References (34)

1. 1. Huber, R., and Carrell, R. W. (1989) Biochemistry 28, 8951-8966.
2. 2. Mourney, L., Samama, J. P., Delarue, M., Choay, J., Petitou, M., and Moras, D. (1990) Biochemie 72, 599-608.
3. 3. Pratt, C. W., and Church, F. C. (1991) Semin. Hematol. 28, 3-9.
4. 4. Olson, S. T., and Bjork, I. (1992) in Thrombin: Structure and Function (Berliner, L. J., Ed.), pp. 159-217. Plenum, New York.
5. 5. Casu, B. (1985) Adv. Carbohydr. Chem. 43, 51-134.
6. 6. Choay, J., Lormeau, J. C., Petitou, M., Sinay, P., and Fareed, J. (1981) Ann. N.Y. Acad. Sci. 370, 644-649.
7. 7. Thunberg, L., Blackstrom, G., and Lindahl, U. (1982) Carbohydr. Res. 100, 393-410.
8. 8. Choay, J. (1989) Semin. Thromb. Hemostasis 15, 359-364.
9. 9. Ragazzi, M., Ferro, D. J., Perly, B., Sinay, P., Petitou, M., and Choay, J. (1990) J. Carbohydr. Res. 195, 169-185.
10. 10. Carrell, R. W., Stein, P. E., Fermi, G., and Wardell, M. R. (1994) Structure 2, 257-270.
11. 11. Schreuder, H. A., de Boer, Bijtske, Dijkema, R., Mulders, J., Theunissen, H. J. M., Grootenhuis, P. D. J., and Hol, W. G. J. (1994) Struct. Biol. 1, 48-54.
12. 12. Najjam, S., Chadeuf, G., Gandrille, S., and Aiach, A. (1994) Biochim. Biophys. Acta 1225, 135-143.
13. 13. Lindahl, U., Backstrom, G., and Thunberg, L. (1983) J. Biol. Chem. 258, 9826-9830.
14. 14. Atha, D. H., Lormeau, J. C., Petitou, M., Rosenberg, R. D., and Choay, J. (1985) Biochemistry 26, 6723-6729.
15. 15. Petitou, M., Duchaussoy, P., Lederman, I., and Choay, J. (1988) Carbohydr. Res. 179, 163-172.
16. 16. Reisenfeld, J., Thunberg, L., and Lindahl, U. (1983) Proc. 7th Int. Symp. Glycoconjug., 390-391.
17. 17. Reisenfeld, J., Thunberg, L., Hook, M., and Lindahl, U. (1981) J. Chem. 256, 2389.
18. 18. van Boeckel, C. A. A., Lucas, H., van Aelst, S. F., van der Niewenhof, M. W. P., Wagenaars, G. N., and Mellema, J. R. (1987) Rec. Trav. Chim. Pays-Bas 106, 581-591.
19. 19. Beetz, T., and van Boeckel, C. A. A. (1986) Tetrahedron Lett. 27, 5889-5892.
20. 20. Choay, J., Petitou, M., Lormeau, J. C., Sinay, P., Casu, B., and Gatti, G. (1983) Biochem. Biophys. Res. Commun. 116, 492-499.
21. 21. Petitou, M., Lormeau, J. C., Nias, B., and Choay, J. (1991) Semin. Thromb. Hemostasis 17, 143-146.
22. 22. Tyler-Cross, R., Sobel, M., Marques, D., and Harris, R. (1994) Protein Sci. 3, 620-627.
23. 23. Sobel, M., Soler, D. F., Kermode, J. C., and Harris, R. B. (1992) J. Biol. Chem. 267, 8857-8862.
24. 24. Soler-Ferran, D., Sobel, M., and Harris, R. B. (1992) Biochemistry 31, 5010-5016.
25. 25. Tyler-Cross, R., Sobel, M., Marques, D., Soler, D. F., and Harris, R. B. (1993) Arch. Biochem. Biophys. 306, 528-533.
26. 26. You, J. L., Page, J. D., Coleman, R. W., and Harris, R. B. (1993) Peptides 14, 867-876.
27. 27. Page, J. D., You, J. L., Harris, R. B., and Colman, R. W. (1994) Arch. Biochem. Biophys. 314, 159-164.
28. 28. Tien, A. N., and Lie, M. (1977) Thromb. Res. 10, 399-410.
29. 29. Sobel, M., Tyler-Cross, R., Marques, D., Bird, K., Toma, N., and Harris, R. B. (1996) Circulation, in press.
30. 30. Mach, H., Volkin, D. B., Burke, C. J., Middaugh, C. R., Linhardt, R. J., Fromm, J. R., Loganathan, D., and Mattsson, L. (1993) Biochemistry 32, 5480-5489.
31. 31. Fan, B., Turko, I. V., and Gettins, P. G. W. (1994) Biochemistry 33, 14156-14161.
32. 32. DeLauder, S., Schwarz, F. P., Williams, J. C., Jr., and Atha, D. H. (1992) Biochim. Biophys. Acta 1159, 141-149.
33. 33. van Boeckel, C. A. A., and Petitou, M. (1993) Angew. Chem. Int. Ed. Engl. 32, 1671-1690.
34. 34. Martinez, J. C., El Harrous, M., Filimonov, V. V., Mateo, P. L., and Fersht, A. R. (1994) Biochemistry 33, 3919-3926.