The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation

Thrombosis Research

Volumn 84, Issue 2, 1996, Pages 83-95

  Chou, Tz Chong ^a   Hsu, Ling Yih ^a   Yen, Mao Hsiung ^a   Ding, Yu An ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

2 heteroaryl 2' substituted phenyl ketone derivatives; cyclooxygenase activity; platelet function; thromboxane A2

Indexed keywords

2 THIENYL 2' HYDROXYPHENYL KETONE; ADRENALIN; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; C85; CALCIUM; COLLAGEN; PROSTAGLANDIN E2; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE FUNCTION;

EID: 0030588162     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-3848(96)00164-8     Document Type: Article

References (28)

1. MUSTARD JF Function of platelets and their role in thrombosis. Trans Am Clin Climatol Ass. 87:1976;104-127.
2. PACKHAM MA, Mustard JF The role of platelets in the development and complications of atherosclerosis. Semin Hematol. 23:1986;8-26.
3. MEHTA J, MEHTA P Platelet function in hypertension and effect of therpy. Am J Cardiol. 474:1981;331-334.
4. DING YA, CHOU TC, HUAN R, LIN KC Platelet specific proteins and other factors to atherosclerosis in various stages of hypertension. Clin Expt Hypertens [A]. 13(8):1991;1329-1341.
5. MONCADA S, VANE JR Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull. 34:1978;129-135.
6. GRYGLEWSKI RJ, BUNTING S, MONCADA S, FLOWER RJ, VANE JR Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxidase. Prostaglandin. 12:1976;685-713.
7. 2 and prostacyclin. Pharmacol Rev. 30:1978;293-331.
8. DING YA, CHOU TC, YIN CS, LIN KC The role of platelet aggregation in pregnancy-induced hypertension -A comprehensive and longitudinal study. Int J Cardiol. 33:1991;125-132.
9. 2/prostaglandin endoperoxide receptor blockade combined in one molecule-1, plarmacological effects in vivo and ex vivo. Throm Haemost. 61:1989;35-42.
10. 2 synthetase inhibitor. Eur J Pharmacol. 147:1988;359-365.
11. DING YA, CHOU TC, CHERN JW, YEN MH Antiplatelet actions of 2-{4-[1-(2-chlorophenyl)piperazinyl]}methyl-2,3-dihydroimidazo[1,2-C]qui nazolin-5(6H)-one compound. Thromb Res. 77:1995;291-303.
12. O'BRIEN JR Platelet aggregation II. Some results from a new method of study. J Clin Path. 15:1962;452-455.
13. DELUCA M, MCELORY WD Purification and properties of firely luciferase. Methods Enzymol. 57:1978;3-15.
14. 2+ store: Studies using Fura-2. Biochem Biophys Res Commun. 139:1986;308-314.
15. NEYLON CB, SUMMERS RJ Stimulation of α 1-adrenoceptors in rat kidney mediates increased inositol phospholipid hydrolysis. Br J Pharmacol. 91:1987;367-376.
16. 3. Prostaglandin. 21:1981;727-738.
17. BELL RL, KENNERLY DA, STANFORD N, MAJERUS PW Diglyceride lipase: A pathway for arachidonic acid release from human platelets. Proc Natl Acad Sci(U.S.A.). 76:1979;1790-1792.
18. 2 activity specific for phosphatidic acid: A possible mechanism for the production of arachidonic acid in platelets. J Biol Chem. 256:1981;5399-5403.
19. ARMSTRONG RA, JONES RL, WILSON NH Ligand binding to thromboxane receptors on human platelets: correlation with biological activity. Br J Pharmacol. 79:1983;953-964.
20. HAMBERG M, SVENSSON J, SAMUELSSON B Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Aci USA. 72:1975;2994-2998.
21. HUANG EM, DETWILER TC Characteristics of the synergistic actions of platelet agonists. Blood. 57:1981;685-691.
22. LAPETINA EG, CHANDRABOSE KA, CUATRECASAS P Ionophore A23187 - and thrombin -induced platelet aggregation :Independence from cyclooxygenase products. Proc Natl Acad Sci U.S.A. 75:1978;818-822.
23. 2/prostaglandin endoperoxide receptor in rabbit platelets. Thromb Res. 66:1992;61-73.
24. PACKHAM MA, MUSTARD JF Clinical plarmacology of platelets. Blood. 50:1977;555-573.
25. BERRIDGE MJ Inositol triphosphate, diacylglycerol as second messenger. Biochem J. 220:1984;345-360.
26. NISHIZUKA Y Turnover of inositol phospholipids and signal transduction. Science. 225:1984;1365-1370.
27. 2+ transporting membrane vesicle fraction derived from human platelets. J Biol Chem. 260:1985;956-962.
28. LAPETINA EG, WATSON SP, CUATRECASAS P Myo-inositol 1,4,5-triphosphate stimulates protein phosphorylation in saponin-permeablized human platelets. Proc Natl Acad Sci USA. 81:1984;7431-7435.