Effect of the cholecystokinin-B receptor antagonist L-365,260 on lactate-induced panic attacks in panic disorder patients

Biological Psychiatry

Volumn 40, Issue 8, 1996, Pages 804-806

  Van Megen, Harold J G M ^a,b   Westenberg, Herman G M ^a   Den Boer, Johan A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

CCK B receptor antagonist; cholecystokinin B receptor; human study; panic disorder; sodium DL lactate

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; LACTIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PANIC; PRIORITY JOURNAL;

EID: 0030588159     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(96)00250-8     Document Type: Article

References (10)

1. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders. Washington, DC.
2. Bradwejn J, Koszycki D, Payena R, et al (1992): Study of the replication of action of cholecystokinin in panic disorders. Am J Psychiatry 149:962-964.
3. Bradwejn J, Koszycki D, Couëtoux du Tertre A, et al (1994): The panicogenic effects of CCK-tetrapeptide are antagonized by L-365,260, a central CCK receptor antagonist in patients with panic disorder. Arch Gen Psychiatry 51:486-493.
4. Coplan JD, Liebowitz MR, Gorman JM, et al (1992): Noradrenergic function in panic disorder effects of intravenous clonidine pretreatment on lactate induced panic, Biol Psychiatry 31:135-146.
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9. van Megen HJGM, den Boer JA, Westenberg HGM (1994): On the significance of cholecystokinin receptors in panic disorder. Prog Neuropsychopharmacol 18:1235-1246.
10. Westenberg HGM, den Boer JA (1994): Neuropharmacology of anxiety. In Handbook of Anxiety and Depression. Marcel Dekker, 405-447.