Effects of the PCP analog dizocilpine on sensory gating: Potential relevance to clinical subtypes of schizophrenia

Biological Psychiatry

Volumn 40, Issue 8, 1996, Pages 744-754

  Al Amin, Hassen A ^a   Schwarzkopf, Steven B ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

acoustic startle reflex; animal models; dizocilpine; prepulse facilitation; prepulse inhibition

Indexed keywords

DIZOCILPINE; DOPAMINE; GLUTAMIC ACID; PHENCYCLIDINE;

ANIMAL EXPERIMENT; ARTICLE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030588076     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00485-8     Document Type: Article

References (53)

1. Antelman SM (1991): Possible animal model of some of the schizophrenia and their response to drug treatment. In Steinhaur SR, Gruzlier JH, Zubin J (eds), Handbook of Schizophrenia, vol 5: Neuropsychology, Psychophysiology and Information Processing. New York: Elsevier Science Publishers, pp 161-180.
2. Bakshi VP, Swerdlow NR, Geyer MA (1994): Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Therapeut 271:787-794.
3. Bogerts B, Meertz E, Schonfeldt-Bausch R (1985): Basal ganglia and limbic system pathology in schizophrenia. Arch Gen Psychiatry 42:784-791.
4. Bogerts B, Ashtari M, Degreet G, Alvir JM, Bilder RM, Lieberman JA (1990): Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res: Neuroimaging 35:1-13.
5. Braff DL, Geyer MA (1990): Sensory gating and schizophrenia: human and animal models. Arch Gen Psychiatry 47:181-188.
6. Braff DL, Grillon C, Geyer MA (1992): Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215.
7. Braff DL, Stone C, Callaway E, Geyer MA, Glick ID, Bali L (1978): Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343.
8. Bullock R, Kuroda Y, Teasdale GM, McCulloch J (1992): Prevention of Post-traumatic excitotoxic brain damage with NMDA antagonist drugs: a new strategy for the nineties. Acta Neurochirurgica-Supplementum 55:49-55.
9. Clineschmidt BV, Martin GE, Bunting PR (1982a): Anticonvulsant activity (+)-5-methyl-10,11-dihydro-5 -H-dibenzo-[a,d]cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties. Drug Dev Res 2:123-134.
10. Clineschmidt BV, Martin GE, Bunting PR, Papp NL (1982b): Central sympathomimetic activity of (+)-5-methyl-10,11-dihydro-5-H-dibenzo[a,b]cyclohepten-5,10-imine (MK801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties. Drug Dev Res 2:135-146.
11. Davis M (1980): Neurochemical modulation of sensory-motor reactivity: Acoustic and tactile startle reflexes. Neurosci Behav Rev 4:241-263.
12. Davis M, Aghajanian GK (1976): Effects of apomorphine and haloperidol in the acoustic startle response in rats. Psychopharmacology 47:217-233.
13. Dawson ME, Hazlett EA, Filion DL, Nuechterlein KH, Schell AM (1993): Attention and Schizophrenia: Impaired modulation of the startle reflex. J Abnorm Psychol 02:633-641.
14. Deutsh SI, Mastropaolo J, Schwartz BL, Rosse RB, Morihisa JM (1989): A "glutamatergic hypothesis" of schizophrenia: rationale for pharmacotherapy with glycine. Clin Neuropharmacol 12:1-13.
15. Domino EF, Luby E (1973): Abnormal mental states induced by phencyclidine as a model of schizophrenia. In Cole JO, Freedman AM, Friedhoff (eds), Psychopharmacology and Psychopathology. Baltimore, MD: Johns Hopkins University Press, pp 37-50.
16. Geyer MA, Braff DL (1982): Habituation of the blink reflex in normals and schizophrenic patients. Psychophysiology 19: 1-6.
17. Geyer MA, Segal DS, Greenberg BD (1984): Induced startle responding in rats treated with Phencyclidine. Neurotoxicol Teratol 6:1-4.
18. Geyer MA, Swerdlow NR, Mansbach RS, Braff DL (1990): Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull 25:485-498.
19. Graham F (1975): The more or less startling effects of weak prestimuli. Psychophysiology 12:238-248.
20. Graham FK, Murray GM (1977): Discordant effects of weak prestimulation on magnitude and latency of reflex blink. Physiol Psychol 5:108-114.
21. Grillon C, Ameli R, Charney DS, Krystal J, Braff DL (1992): Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol Psychiatry 32:939-943.
22. Hitri A, O'Conner DA, Cohen JM, Keuler DJ, Deutsh SI (1993): Differentiation between MK-801-and apomorphine-induced stereotyped behavior in mice. Clin Neuropharmacol 16:220-236.
23. Hoffman DC, Donovan H, Cassella JV (1993): The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801. Psychopharmacology 111:339-344.
24. Hoffman HS, Ison JR (1980): Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system process sensory input. Psychol Rev 2:175-189.
25. Ison JR, Hammond GR (1971): Modification of the startle reflex in the rat by changes in the auditory and visual environments. J Comp Physiol Psychol 75:435-452.
26. Ison JR, McAdam DW, Hammond GR (1973): Latency and amplitude changes in the acoustic startle reflex of the rat produced by variation in auditory prestimulation. Physiol Behav 10:1035-1039.
27. Javitt DC (1987): Negative symptomatology and the PCP model of schizophrenia. Hillside J Clin Psychiatry 9:12-35.
28. Javitt DC, Zukin SR (1991a): Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301-1308.
29. Javitt DC, Zukin SR (1991b): Mechanisms of Phencyclidine (PCP)-N-Methyl-D-Aspartate (NMDA) receptor interaction: Implications for schizophrenia. In Tamminga CA, Schulz SC (eds), Advances in Neuropsychiatry and Psychopharmacology, vol 1: Schizophrenia Research. New York: Raven Press, pp 13-19.
30. Johnson KM (1987): Neurochemistry and neurophysiology of phencyclidine. In Meltzer HY (ed), Psychopharmacology: The Third Generation of Progress. New York: Raven Press, pp 1673-1681.
31. Kane J, Honigfeld G, Singer J, Meltzer H (1988): Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 45:789-796.
32. Keith VA, Mansbach RS, Geyer MA (1991): Failure of Haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry 30:557-566.
33. Kellog CK, Sullivan AT, Bitran D, Ison JR (1991): Modulation of noise-potentiated acoustic startle via the benzodiazepine-gamma-aminobutyric acid receptor complex. Behav Neurosci 5:640-646.
34. Kovelman JA, Scheibel AB (1984): A neurohistological correlate of schizophrenia. Biol Psychiatry 19:1601-1621.
35. Mansbach RS (1991): Effects of NMDA receptor ligands on sensorimotor gating in the rat. Eur J Pharmacology 202:61-66.
36. Mansbach RS, Geyer MA (1989): Effect of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2:299-308.
37. Mansbach RS, Geyer MA (1991): Parametric determinants in prestimulus modification of acoustic startle: interaction with ketamine. Psychopharmacology 105:162-168.
38. Mansbach RS, Geyer MA, Braff DL (1988): Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94:507-514.
39. McGhie A, Chapman J (1961): Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34:103-116.
40. Peng RY, Mansbach RS, Braff DL, Geyer MA (1990): A D2 dopamine receptor agonist disrupts sensorimotor gating in rats: Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology 3:211-218.
41. Schwarzkopf SB, Bruno JP, Mitra T (1993): Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions. Prog Neuropsychopharmacol Biol Psychiatry 17:1023-1036.
42. Schwarzkopf SB, Ison JR, Taylor MK, Barlow J (1994a): Apomorphine disrupts prepulse facilitation and inhibition of startle. Biol Psychiatry 35:630 (abstract).
43. Schwarzkopf SB, Al-Amin HA, Ison JR (1994b): Clozapine, but not D1/D2 dopamine antagonists, reverses sensorimotor gating deficits and hypermotility induced by an NMDA antagonist: Pathophysiologic implications. Society for Neuroscience (abstract).
44. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M, McCarley RW (1992): Abnormalities of the left temporal lobe and thought disorder in schizophrenia. N Engl J Med 327:604-612.
45. Suddath RL, Chrisison GW, Fuller Torrey E, Casanova MF, Weinberger DR (1990): Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 322:789-794.
46. Swerdlow NR, Braff DL, Geyer MA, Koob GF (1986): Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biol Psychiatry 21:23-33.
47. Swerdlow NR, Braff DL, Masten VL, Geyer MA (1990): Schizophrenic-like sensorimotor gating: abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology 101:414-420.
48. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994): Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51: 139-154.
49. Swerdlow NR, Keith VA, Braff DL, Geyer MA (1991): Effects of Spiperone, raclopride, SCH 23390 and Clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol and Exp Therapeut 256: 530-536.
50. Venables P (1964): Input dysfunction in schizophrenia. In Maher BA (ed), Progress in Experimental Personality Research. New York: Academic Press, pp 1-47.
51. Wong EHF, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL (1986): The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:7104-7108.
52. Wu J, Potkin SG, Ploszaj DI, Lau V, Telford J, Richmond G (1992): Clozapine improves sensory gating more than haldol. New Research Proceedings APA, p 156.
53. Zukin SR, Zukin RS (1979): Specific [3H] phencyclidine binding in rat central nervous system. Proc Natl Acad Sci USA 76:5372-5376.