Reduction of the current of injury leaving the amputation inhibits limb regeneration in the red spotted newt

Developmental Biology

Volumn 178, Issue 2, 1996, Pages 251-262

  Jenkins, Lisa S ^a   Duerstock, Bradley S ^a   Borgens, Richard B ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ELECTRIC POTENTIAL; INJURY; ION CURRENT; LIMB AMPUTATION; LIMB REGENERATION; NEWT; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; CAUDATA; NOTOPHTHALMUS VIRIDESCENS; SALAMANDRIDAE;

EID: 0030587615     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1996.0216     Document Type: Article

References (51)

1. Borgens, R. B. (1977). Skin batteries and limb regeneration. Nat. Hist. 86, 84-89.
2. Borgens, R. B. (1982). What is the role of naturally produced electric current in vertebrate regeneration and healing? Int. Rev. Cytol. 76, 245-298.
3. Borgens, R. B. (1985). Natural voltage gradients and the generation and regeneration of the amphibian limb. In "Regulation of Amphibian Limb Regeneration" (R. E. Sicard, Ed.), Chap. 2, pp. 6-31. Oxford Univ. Press, New York.
4. Borgens, R. B. (1988). Stimulation of neuronal regeneration and development by steady electrical fields. In "Advances in Neurology, Vol. 47: Functional Recovery in Neurological Diseases" (S. G. Waxman, Ed.), pp. 547-564. Raven Press, New York.
5. Borgens, R. B. (1989a). Natural and applied currents in limb regeneration and development. In "Electric Fields in Vertebrate Repair" (Coauthored by R. B. Borgens, K. R. Robinson, J. W. Vanable, Jr., and M. E. McGinnis), Chap. 2, pp. 27-75. A. R. Liss, New York.
6. Borgens, R. B. (1989b). Artificially controlling axonal regeneration and development by applied electric fields. In "Electric Fields in Vertebrate Repair" (Coauthored by R. B. Borgens, K. R. Robinson, J. W. Vanable, Jr., and M. E. McGinnis), Chap. 4, pp. 117-170. A. R. Liss, New York.
7. Borgens, R. B. (1992). Applied voltages in spinal cord reconstruction: History, strategies, and behavioural models. In "Spinal Cord Dysfunction, Volume III: Functional Stimulation," pp. 110-145. Oxford Univ. Press, Oxford, UK.
8. Borgens, R. B., and Shi, R. (1995). Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential. Dev. Dynamics 203, 456-467.
9. Borgens, R. B., Vanable, J. W., Jr., and Jaffe, L. F. (1977a). Bioelectricity and regeneration. Large currents leave the stumps of regenerating newt limbs. Proc. Natl. Acad. Sci. USA 74, 4528-4532.
10. Borgens, R. B., Vanable, J. W., Jr., and Jaffe, L. F. (1977b). Bioelectricity and regeneration. I. Initiation of frog limb regeneration by minute currents. J. Exp. Zool. 200, 403-416.
11. Borgens, R. B., Vanable, J. W., Jr., and Jaffe, L. F. (1979a). Reduction of sodium dependent stump currents disturbs urodele limb regeneration. J. Exp. Zool. 209, 377-386.
12. Borgens, R. B., Vanable, J. W., Jr., and Jaffe, L. F. (1979b). Role of subdermal current shunts in the failure of frogs to regenerate. J. Exp. Zool. 209, 49-56.
13. Borgens, R. B., Vanable, J. W., Jr., and Jaffe, L. F. (1979c). Small artificial currents enhance Xenopus limb regeneration. J. Exp. Zool. 207, 217-226.
14. Borgens, R. B., Rouleau, M. F., and DeLanney, L. E. (1983). A steady efflux of ionic current predicts hind limb development in the axolotl. J. Exp. Zool. 228, 491-503.
15. Borgens, R. B., McGinnis, M. E., Vanable, J. W., Jr., and Miles, E. S. (1984). Stump currents in regenerating salamanders and newts. J. Exp. Zool. 231, 249-256.
16. Bryant, S. V. (1976). Regenerative failure of double half limb in Notophthalmus viridescens. Nature (London) 263, 676-679.
17. Chiang, M., Cragoe, E. J., Jr., and Vanable, J. W. (1989). Electrical fields in the vicinity of small wounds in Notophthalmus viridescens skin. Biol. Bull. 176(S), 179-183.
18. Chiang, M., Cragoe, E. J., Jr., and Vanable, J. W. (1991). Intrinsic electrical fields promote epithelialization of wounds in the Newt, Notophthalmus viridescens. Dev. Biol. 146, 377-385.
19. Cooke, J. (1995). Morphogens in vertebrate development: How do they work? Bioessay 17(2), 93-96.
20. Duboule, D. (1992). The vertebrate limb: A model system to study the Hox/HOM gene network during development and evolution. BioEssays 14, 375-384.
21. Goode, R. P. (1967). The regeneration of limbs in adult anurans. J. Embryol. Exp. Morphol. 18, 259-267.
22. Goss, R. J. (1956). Regenerative inhibition following limb amputation and immediate insertion into the body cavity. Anat. Rec. 126, 15-72.
23. Goss, R. J., and Holt, R. (1992). Epimorphic vs. tissue regeneration in Xenopus forelimbs. J. Exp. Zool. 261, 451-457.
24. Hall, A. B., and Schotté, O. E. (1951). Effects of hypophysectomies upon the initiation of regenerative processes in the limbs of Titurus viridescens. J. Exp. Zool. 118, 363-387.
25. Hotary, K. B., and Robinson, K. R. (1990). Endogenous electrical currents and the resultant voltage gradients in the chick embryo. Dev. Biol. 140, 149-160.
26. Iten, L., and Bryant, S. V. (1973). Forelimb regeneration from different levels of amputation in the newt, N. viridescens: Length, rate, and stages. Wilhelm Roux Arch. 173, 263-628.
27. Jaffe, L. F., and Nuccitelli, R. (1974). An ultrasensitive-vibrating probe for measuring steady extracellular currents. J. Cell Biol. 63, 614-628.
28. Jaffe, L. F., and Nuccitelli, R. (1977). Electrical control of development. Annu. Rev. Biophys. Bioeng. 6, 445-476.
29. Johnson, R. L., Riddle, R. D., and Tabin, C. J. (1994). Mechanisms of limb patterning. Curr. Opin. Genet. Dev. 4, 535-542.
30. McGinnis, M. E., and Vanable, J. W., Jr. (1986a). Electrical fields in Notophthalmus viridescens limb stumps. Dev. Biol. 116, 184-193.
31. McGinnis, M. E., and Vanable, J. W., Jr. (1986b). Wound epithelium resistance controls stump currents. Dev. Biol. 116, 174.
32. Mescher, A. L. (1976). Effects on adult newt limb regeneration of partial and complete skin flaps over the amputation surface. J. Exp. Zool. 195, 117-127.
33. Metcalf, M. E. M., and Borgens, R. B. (1994). Weak applied voltages interfere with amphibian morphogenesis and pattern. J. Exp. Zool. 268, 322-338.
34. Metcalf, M. E. M., Shi, R., and Borgens, R. B. (1994). Endogenous ionic currents and voltages in amphibian embryos. J. Exp. Zool. 268, 307-322.
35. Muneoka, K., and Sassoon, S. (1992). Molecular aspects of regeneration in developing vertebrate limbs. Dev. Biol. 152, 37-49.
36. Polezhaev, L. V. (1972). "Loss and Restoration of Regenerative Capacity in Tissues and Organs of Animals." Harvard Univ. Press, Cambridge, MA.
37. Rajnicek, A. M., Stump, R. F., and Robinson, K. R. (1988). An endogenous sodium current may mediate wound healing in Xenopus neurulae. Dev. Biol. 128, 290-299.
38. Robinson, K. R. (1983). Endogenous electrical current leaves the limb and prelimb region of the Xenopus embryo. Dev. Biol. 79, 203-211.
39. Schotté, O. E. (1926). Hypophysectomie et régénération chez les batraciens urodèles. C.R. Soc. Phys. Hist. Nat. Geneve 43, 67-72.
40. Schotté, O. E., and Harland, H. (1943). Amputation level and regeneration in limbs of the late Rana clamitans tadpoles. J. Morphol. 73, 329-363.
41. Schotté, O. E., and Wiber, J. F. (1958). Effects of adrenal transplants upon forelimb regeneration in normal and in hypophysectomized adult frogs. J. Embryol. Exp. Morphol. 6, 247-269.
42. Shi, R., and Borgens, R. B. (1995). Three dimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic pattern. Dev. Dynamics 202, 101-114.
43. Singer, M. (1974). Neurotropic control of limb regeneration in the newt. Ann. N.Y. Acad. Sci. 228, 308-321.
44. Spallanzani, L. (1768). "Prodromo sa un Opera da Im prim ersi sopra le Ripoduzion Animali." Modena (7).
45. Stocum, D. (1995). Regeneration of amphibian limbs. In "Wound Repair, Regeneration and Artificial Tissue," Chap. 4. Landesco, Austin, TX.
46. Todd, T. J. (1823). On the process of reproduction of the members of the aquatic salamander. Q. J. Lit. Sci. Arts 16, 84.]
47. Tornier, G. (1906). Kampf der Gewebe im Regenerat bei Begünstigung der Hautregeneration. Roux Arch. 22, 348-369.
48. Vanable, J. W., Hearson, L. L., and McGinnis, M. E. (1983). The role of endogenous electrical fields in limb regeneration. In "Limb Development and Regeneration," pp. 587-596. A. R. Liss, New York.
49. Wallace, H. (1981a). Nervous control. In "Vertebrate Limb Regeneration," Chap. 2, pp. 22-52. Wiley, New York.
50. Wallace, H. (1981b). Regional and axial determination. In "Vertebrate Limb Regeneration," Chap. 8, pp. 156-191. Wiley, New York.
51. Wilson, S., Tonge, D. A., and Holder, N. (1989). Homing behaviour of regenerating axons in the amphibian limb. Development 106, 707-715.