Lack of influence of histopathological changes on carbamazepine and carbamazepine-10,11-epoxide concentrations in the brain cortex of epileptic patients

Journal of the Neurological Sciences

Volumn 141, Issue 1-2, 1996, Pages 87-94

  Schnabel, Ralf ^a   Rambeck, Bernhard ^b   May, Theodor ^b   Jürgens, Uwe ^b   Lahl, Reiner ^c   Fritsch, Wolfgang ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b Epilepsy Research Foundation   (Germany)

^c EPILEPSY CENTER BETHEL   (Germany)

Author keywords

Binding site; Brain concentration; Carbamazepine; Carbamazepine 10,11 epoxide; Cortical lesion; Epilepsy

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; DRUG METABOLITE;

ADULT; AGED; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPSY; FEMALE; GLIOSIS; HISTOLOGY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL;

EID: 0030587595     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(96)00125-6     Document Type: Article

References (27)

1. Albright, P.S. and J. Bruni (1984) Effects of carbamazepine and its epoxide metabolite on amygdala-kindled seizures in rats. Neurology, 34: 1383-1386.
2. Bertilsson, L. and T. Tomson (1986) Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update. Clin. Pharmacokin., 11: 177-198.
3. Bourgeois, B.F.D. and N. Wad (1984) Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in mice. J. Pharmacol. Exp. Ther., 231: 411-415.
4. Bowling, A.C. and R.J. DeLorenzo (1982) Micromolar benzodiazepine receptors: Identification and characterization in central nervous system. Science, 216: 1247-1250.
5. Braestrup, C. and R.F. Squires (1978) Pharmacological characterization of benzodiazepine receptors in the brain. Eur. J. Pharmacol., 48: 263-270.
6. DeLorenzo, R.J. (1989) Phenytoin, Mechanisms of action. In: Levy, R., Mattson, R., Meldrum, B., Penry, J.K. and Dreifuss, F.E. (Eds.), Antiepileptic Drugs, Raven Press, New York, pp. 143-158.
7. Endicott, J.A. and V. Ling (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem., 58: 137-171.
8. Faigle, J.W. and K.F. Feldman (1982) Carbamazepine, Biotransformation. In: Woodbury, D.M., Penry, J.K. and Pippenger, C.E. (Eds.), Antiepileptic Drugs, 2nd edition, Raven Press, New York, pp. 483-495.
9. Frigerio, A. and P.L. Morselli (1975): Carbamazepine: Biotransformation. In: Penry, J.K. and Daly, D. (Eds.), Advances in Neurology, Vol. II, Raven Press, New York, pp. 295-308.
10. Jürgens, U. and B. Rambeck (1987) Sensitive analysis of antiepileptic drugs in very small portions of human brain by microbore HPLC. J. Liquid Chromatogr., 10: 1847-1863.
11. Kerr, B.M. and R.H. Levy (1989) Carbamazepine; Carbamazepine Epoxide. In: Levy, R., Mattson, R., Meldrum, B., Penry, J.K. and Dreifuss, F.E. (Eds.), Antiepileptic Drugs, 3rd Edition, Raven Press, New York, pp. 505-520.
12. Lahl, R., T. May, B. Rambeck and R. Schnabel (1993) Antiepileptika-Konzentrationen in epileptogenen Hirnregionen bei funktionellen Hemispherektomien anfallskranker Kinder. In: Nissen, G. (Ed.), Anfallskrankheiten aus interdisziplinärer Sicht, Hans Huber, Bern, pp. 108-114.
13. Morrow, C.S. and K. Cowan (1993) Drug resistance and cancer. Adv. Exp. Med. Biol. 330:287-305.
14. Rall, D.P. and J.D. Fenstermacher (1971) Volume of cerebral extracellular fluids. In: Siesjö, B.K. and Sørensen, S.C. (Eds.), Ion homeostasis of the brain, Munksgaard, Copenhagen; Academia Press, New York, pp. 29-37.
15. Rambeck, B., R. Schnabel, T. May, U. Jürgens and R. Villagrán (1990) Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients. Ther. Drug Monit., 12: 533-540.
16. Rambeck, B., R. Schnabel, T. May, U. Jürgens and R. Villagrán (1992) Postmortem concentrations of phenytoin in different regions of the brain and in the serum: analysis of autoptic specimens from 24 epileptic patients. Ther. Drug Monit., 14: 27-35.
17. Rambeck, B., R. Schnabel, T. May, U. Jürgens and R. Villagrán (1993) Postmortem concentrations of phenobarbital, carbamazepine, and its metabolite carbamazepine-10,11-epoxide in different regions of the brain and in the serum: analysis of autoptic specimens from 51 epileptic patients. Ther. Drug Monit., 15: 91-98.
18. Stam, F.C. and P.A. Roukema (1973) Histochemical and biochemical aspects of corpora amylacea. Acta Neuropathol., 25: 95-102.
19. Schnabel, R., B. Rambeck, T.W. May, U. Jürgens and R. Villagrán (1994a) Phenytoin-und Phenobarbital-Konzentrationen in der Hirnrinde von Epilepsiepatienten mit apallischem Syndrom. In: Jerusalem, F. and Ries, F. (Eds.), Metabolische Erkrankungen des ZNS, Muskelerkrankungen, Epilepsie, freie Themen, Köllen Druck und Verlag, Bonn, pp. 297-299.
20. Schnabel, R., B. Rambeck, T.W. May, U. Jürgens and R. Lahl (1994b) Concentrations of carbamazepine and carbamazepine-10,11-epoxide in serum, brain tumors and paratumorous cortex: A prospective study of 37 neurosurgically treated epileptic patients. Eur. Neurol., 34: 213-220.
21. Schnabel, R., B. Rambeck, T.W. May, U. Jürgens, R. Lahl and R. Villagrán (1995) Lack of effect of histological lesions on the phenytoin and phenobarbital concentrations in the brain cortex of epileptic patients. J. Neurol. Sci., 133: 177-182.
22. Scheyer, R.D., M.J. During, D.D. Spencer, J.A. Cramer and R.H. Mattson (1994) Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysis. Neurology, 44: 1469-1472.
23. Sillanpäa, M. (1981) Carbamazepine. Pharmacology and clinical uses. Acta Neurol. Scand., 64 (suppl.64): S1-S202.
24. Sillanpää, M. (1993) Carbamazepine. In: Wyllie, E. (Ed.) The treatment of epilepsy: Principles and practice, Lea and Febiger, Philadelphia, pp. 876-886.
25. Tomson, T., O. Almkvist, B.Y. Nilsson, J.-O. Svensson and L. Bertilsson (1990) Carbamazepine-10,11-epoxide in epilepsy. A pilot study. Arch. Neurol., 47: 888-892.
26. Tomson, T. and L. Bertilsson (1991) Kinetics, metabolism and effects of carbamazepine-10,11-epoxide in man. Epilepsy Res., Suppl.3: 177-181.
27. Wilder, B.J. (1995) The treatment of epilepsy: An overview of clinical practices. Neurology, 45 (suppl.): S7-S11.