Initial increase of plasma serotonin: A biological predictor for the antidepressant response to clomipramine?

Biological Psychiatry

Volumn 40, Issue 6, 1996, Pages 465-473

  Spreux Varoquaux, Odile ^a   Gailledreau, Joel ^b   Vanier, Bernard ^b   Bothua, Dominique ^a   Plas, Joel ^b   Chevalier, Jean François ^b   Advenier, Charles ^a   Pays, Michel ^a   Brion, Serge ^b  

^a CENTRE HOSPITALIER DE VERSAILLES   (France)

^b CENTRE HOSPITALIER DE VERSAILLES   (France)

Author keywords

Biological predictor of response; Clomipramine; Major depressive disorder; Plasma serotonin level; Platelet serotonin level

Indexed keywords

CLOMIPRAMINE; SEROTONIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG RESPONSE; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030587473     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00449-1     Document Type: Article

References (46)

1. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. rev. Washington, DC: American Psychiatric Press.
2. Anderson GM, Feiblel FC, Cohen DJ (1987): Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sci 40:1063-1070.
3. 2 receptor binding properties and their regulation by endogenous serotonin. Life Sci 52:313-321.
4. Badcock NR, Spence JG, Stern LM (1987): Blood serotonin levels in adults, autistic and non autistic children with a comparison of different methodologies. Ann Clin Biochem 24:625-634.
5. Balant-Gorgia AE, Balant LP, Genet C, Dayer P, Aeschlimann JM, Garrone G (1986): Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites. Eur J Clin Pharmacol 31:449-455.
6. Balon R (1989): Biological predictors of antidepressant treatment outcome. Clin Neuropharmacol 12:195-214.
7. Beck O, Wallen H. Bröijersen A, Larsson PT, Hjemdahl P (1993): On the accurate determination of serotonin in human plasma. Biochem Biophys Res Commun 196:260-266.
8. Beck P, Kastrup M, Rafaelsen OJ (1989): Echelles d'anxiété, de manie, de dépression, de schizophrénie, in Eds Paris: Masson, pp 43-56.
9. Beckmann A, Godwin FK (1975): Antidepressant response to tricyclics and urinary MHPG in unipolar patients. Arch Gen Psychiatry 32:17-21.
10. Blum I, Vered Y, Graff E, et al (1992): The influence of meal composition on plasma serotonin and norepinephrine concentrations. Metabolism 41:137-140.
11. Boyer WF, Feighner JP (1991): The serotonin hypothesis: Necessary, but not sufficient. In Wiley J (ed), Selective Serotonin Re-Uptake Inhibitors, Perspectives in Psychiatry. New York: Raven Press, 1:71-80.
12. Carlsson A, Lindqvist M (1978): Effects of antidepressant agents on the synthesis of brain monoamines. J Neurol Transm 43:73-91.
13. Cheetham SC, Horton RW (1992): Brain 5-HT dysfunction in major psychiatric disorders. In Marsden CA, Heal DJ (eds), Central Serotonin Receptors and Psychotropic Drugs. Oxford, London, Edimburgh Boston, Melbourne, Paris, Berlin, Vienne: Blackwell Scientific Publications, pp 126-144.
14. Da Prada M, Cesura AM, Launay JM, Richards JG (1988): Platelets as a model of neurons. Experientia 44:115-125.
15. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Henninger GR (1990): Serotonin function and the mechanism of antidepressant action: Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47:411-418.
16. De Montigny C, Blier P (1992): Effects of antidepressant treatments on 5-HT neurotransmission. In Marsden CA, Heal DJ (eds), Central Serotonin Receptors and Psychotropic Drugs. Oxford, London, Edimburgh Boston, Melbourne, Paris, Berlin, Vienne: Blackwell Scientific Publications, pp 223-238.
17. Evans LEJ, Bett JH, Cox JR, Dubois JP, Van Hees T (1980): The bioavailability of oral and parenteral clomipramine (Anafranil). Prog Neuropsychopharmacol 4:293-302.
18. Flachaire E, Beney C, Berthier A, Salandre J, Quiney C, Renaud B (1990): Determination of reference values for serotonin concentration in platelets of healthy newborns, children, adults, and elderly subjects by HPLC with electrochemical detection. Clin Chem 36:2117-2120.
19. Goodwin GM (1991): Food intake and neurotransmitters. In Idzikowski C, Cowen PJ (eds), Serotonin, Sleep and Mental Disorder, Petersfield, UK: Wrightson Biomedical Publishing Ltd., pp 119-128.
20. Guicheney P (1988): Human platelet serotonin content: Methodological aspects and psychological variations. Meth Find Exp Clin Pharmacol 10:253-258.
21. Hall H, Ögren SO (1981): Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol 70:393-407.
22. Henninger GR, Charney DS (1987): Mechanism of action of antidepressant treatment: Implications for the aetiology and treatment of depressive disorder. In Meltzer HY (ed), Psychopharmacology: The Third Generation of Progress. New York: Raven Press, pp 535-544.
23. Hindberg I, Naesh O (1992): Serotonin concentrations in plasma and variations during the menstrual cycle. Clin Chem 38: 2087-2089.
24. Joyce PR, Paykel ES (1989): Predictors of drug response in depression. Arch Gen Psychiatry 46:89-99.
25. Lingjaerde O (1984): Blood platelets as a model system for studying the biochemistry of depression. In Usdin E, et al (eds), Frontiers in Biochemical and Pharmacological Research in Depression. New York: Raven Press, pp 99-111.
26. Linnoila M, Insel T, Kilts C, Potter WZ, Murphy DL (1982): Plasma steady-state concentrations of hydroxylated metabolites of clomipramine. Clin Pharmacol Ther 32:208-211.
27. Maas JW, Koslow SH, Katz MM, et al (1984): Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. Am J Psychiatry 141:1159-1171.
28. Martensson B, Wagner A, Beck O, Brodien K, Montero D, Asberg M (1991): Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet 3H-imipramine binding and serotonin uptake and concentration in major depressive disorder. Acta Psychiatr Scand 83:125-133.
29. Meltzer HY (1991): Role of serotonin in depression. Ann NY Acad Sci 486-499.
30. Moller SE (1990): 5-HT uptake inhibitors and tricyclic antidepressants: Relation between tryptophan availability and clinical response in depressed patients. Eur Neuropsychopharma-col 1:41-44.
31. Montgomery S (1991): Clinical aspects of onset of action of antidepressant efficacy. Biological Psychiatry 29:114S.
32. Ortiz J, Artigas F, Gelpi E (1988): Serotonergic status in human blood. Life Sci 43:983-990.
33. Pletscher A (1986): Blood platelets as neuronal models: Use and limitations. Clin Neuropharmacol 9:344-346.
34. Potter WZ, Rudorfer MW, Manji H (1991): The pharmacologic treatment of depression. N Engl J Med 325:633-642.
35. Sarrias MJ, Artigas F, Martinez E, Gelpi E (1989): Seasonal changes of plasma serotonin and related parameters: Correlation with environmental measures. Biol Psychiatry 26:695-706.
36. Sarrias MJ, Cabré P, Martinez E, Artigas F (1990): Relationship between serotonergic measures in blood and cerebrospinal fluid simultaneously obtained in humans. J Neurochem 54: 783-786.
37. Spreux-Varoquaux O, Morin D, Advenier C, Pays M (1987): Determination of clomipramine and its hydroxylated and demethylated metabolites in plasma and urine by liquid chromatography with electrochemical detection. J Chromatogr Biomed Appl 416:311-319.
38. Stahl SM (1985): Platelets as pharmacological models for the receptors and biochemistry of monoaminergic neurons. In Longenecker GL (ed), The Platelets: Physiology and Pharmacology. New York: Academic Press, pp 307-340.
39. Stahl SM, Woo DJ, Melford IN, Berger PA, Ciaranello RD (1983): Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders. Am J Psychiatry 140:26-30.
40. Van Praag HM (1977): New evidence of serotonin deficient depression. Neuropsychobiology 3:56-63.
41. Varoquaux O, Morin D, Advenier C, Pays M (1988): Dosage de la sérotonine libre et totale dans le plasma et le sérum par CLHP-EC. Ann Biol Clin 46:598.
42. Varoquaux O, Bonnaud H, Morin D, et al (1989): Influence of cigarette smoking on the pharmacokinetics and metabolism of clomipramine and its hydroxylated and demethylated metabolites in healthy volunteers. Fund Clin Pharm 3:586.
43. White JG (1968): Effects of EDTA on platelet structure. Scand J Haematol 5:241-254.
44. Wirtz-Justice A, Puhringer W (1978): Increased platelet serotonin in bipolar depression and hypomania. J Neural Transm 42:55-62.
45. Wood K (1989): Serotonin and histamine in depressive illness. In Tipton KF, Youdim MB (eds), Biochemical and Pharmacological Aspects of Depression. London: Taylor and Francis, pp 51-68.
46. Wurtman RJ (1988): Effect of their nutrient precursors on the synthesis and release of serotonin, the catecholamines, and acetylcholine: Implications for behavioral disorders. Clin Neuropharmacol 11:s187-s193.