Membrane reactor with soluble forms of penicillin acylase

Enzyme and Microbial Technology

Volumn 19, Issue 3, 1996, Pages 196-201

  Bryjak, Jolanta ^a   Bryjak, Marek ^a   Noworyta, Andrzej ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Membrane reactor; Penicillin acylase; Poly(ethyleneimine)

Indexed keywords

CALCULATIONS; ENZYMES; HYDROLYSIS; POLYETHYLENES; POLYMERIC MEMBRANES; POLYSULFONES; REACTION KINETICS; STABILITY;

ENZYME MEMBRANE REACTOR; KINETIC EQUATIONS; PENICILLIN ACYLASE; POLYETHYLENEIMINE;

BIOREACTORS;

AMIDASE; IMMOBILIZED ENZYME; PENICILLIN G; POLYSULFONE;

ARTICLE; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; ENZYME STABILITY; HYDROLYSIS; KINETICS; MEMBRANE REACTOR;

EID: 0030586927     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/0141-0229(95)00231-6     Document Type: Article

References (21)

1. 1. Iorio, G., Calabro, V., and Todisco, S. Enzyme membrane reactors. In: Membrane Processes in Separation and Purification (Crespo, J. G. and Boddeker, K. W., Eds.). Kluwer Academic Publishers, Dordrecht, 1993, 149-167
2. 2. Prenosil, J. E. and Hediger, T. Performance of membrane-fixed biocatalyst reactor systems and modelling. Biotechnol. Bioeng. 1986, 31, 913-921
3. 3. Fuganti, C. and Rigon, R. Penicillan acylase in the synthesis of aminothiazole cefalosporins. Biotechnol. Lett. 1993, 15, 1163-1166
4. 4. Bahulekar, R. V., Probhune, A. A., SivaRaman, H., and Ponrathnam, S. Immobilization of penicillin G acylase on functionalized macroporous polymer beads. Polymer 1993, 34, 163-166
5. 5. Fonseca, L. P., Cardoso, J. P., and Cabral, J. M. S. Immobilization studies of an industrial penicillin acylase preparation on a silica carrier. J. Chem. Tech. Biotechnol. 1993, 58, 27-37
6. 6. Shewale, J. G. and Sivaraman, H. Penicillin acylase: Enzyme production and its application in the manufacture of 6-APA. Process Biochem. 1989, 8, 148-154
7. 7. Schmidt, R. D. Stabilized soluble enzymes. Adv. Biochem. Eng. 1979, 12, 41-118
8. 8. Weijers, S. R. and Vant'Riet, K. Enzyme stability in downstream processing. Part 1: Enzyme inactivation, stability, and stabilization. Biotechnol. Adv. 1992, 10, 237-249
9. 9. Bryjak, J. and Noworyta, A. Ultrafiltration membrane selection for penicillin G hydrolysis in enzymatic membrane reactor. Inż. Chem. Proc. 1990, 1, 127-142
10. 10. Bryjak, J. and Noworyta, A. Enzyme membrane bioreactor for hydrolysis of penicillin G. In: Biochemical Engineering, Stuttgart (Reuss, M., Chmiel, H., Gilles, E. D., and Knackmuss, H. J., Eds.). Gustav Fischer, Stuttgart, 1991, 122-125
11. 11. Bryjak, J. and Noworyta, A. Improvement of enzyme stability immobilized in membrane reactor. Inż. Chem. Proc. 1993, 1, 83-95
12. 12. Bryjak, J. and Noworyta, A. Storage stabilization and purification of enzyme by water-soluble synthetic polymers. Enzyme Microb. Technol. 1994, 16, 616-621
13. 13. Bryjak, J. Stabilization of penicillin acylase by poly(ethyleneimine). Bioproc. Eng. 1995, 13, 177-181
14. 14. Stengaard, F. F. Characteristic and performance of new types of ultrafiltration membranes with chemically modified surface. Desalination 1988, 70, 207-224
15. 15. Balasingham, K., Warburton, D., Dunnill, P., and Lilly, M. D. The isolation and kinetics of penicillin amidase from Escherichia coli. Biochim. Biophys. Acta 1972, 276, 250-256
16. 16. Lowry, O. H., Rosebrough, N. J., Farr, N. J., and Randall, R. J. Protein measurement with the foulin phenol reagent. J. Biol. Chem. 1951, 193, 265-275
17. 17. Lee, Y.-K. and Choo, C.-L. The kinetics and mechanism of shear inactivation of lipase from Candida cylindracea. Biotechnol. Bioeng. 1989, 33, 183-190
18. 18. Carleysmith, S. W., Dunnill, M. D., and Lilly, M. D. Kinetic behavior of immobilized penicillin acylase. Biotechnol. Bioeng. 1980, 22, 735-756
19. 19. Bryjak, J. and Noworyta, A. Kinetic behavior of penicillin acylase immobilized on acrylic carrier. Bioproc. Eng. 1993, 9, 37-42
20. 20. Bryjak, J. and Noworyta, A. Kinetic behaviour of penicillin acylase stabilized by poly(ethyleneimine). Bioproc. Eng. 1995, 13, 183-187
21. 21. Clark, K. M. and Glatz, C. E. Protein fractionation by precipitation with carboxymethyl cellulose. In: Downstream Processing and Bioseparation. Recovery and Purification of Biological Products, (Hamel, J. F. P., Hunter, J. B., and Sikdar, S. K., Eds.). American Chemical Society, Washington, D.C., 1990, 170-187