N-Methyl-D-aspartate-induced enhancement of activator protein-1 DNA binding activity is blocked by ethanol in cerebellar granule cells

European Journal of Pharmacology

Volumn 309, Issue 3, 1996, Pages 307-310

  Hou, Yan Ning ^a   Cebers, Gvido ^a   Cebere, Aleta ^a   Terenius, Lars ^a   Liljequist, Sture ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

AMPA ( amino 3 hydroxy 5 methyl 4 isoxazole propionic acid); AP 1 (activator protein 1) DNA binding; Cerebellar; Ethanol; Granule cell; NMDA (N methyl Daspartate); Transcription factor

Indexed keywords

ALCOHOL; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DNA BINDING PROTEIN; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ARTICLE; CELL CULTURE; CEREBELLUM; CONTROLLED STUDY; DNA BINDING; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030586779     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00438-4     Document Type: Article

References (15)

1. Bakalkin, G.Y., T. Yakovleva and L. Terenius, 1993, NF-κB-like factors in the murine brain, Mol. Brain Res., 20, 137.
2. 2+ uptake in brain neurons, Eur. J. Pharmac./Mol. Pharmac. Sect. 290, 105.
3. 2+ in dissociated brain cells, Brain Res. 499, 383.
4. Ghosh, A. and M.E. Greenberg, 1995, Calcium signaling in neurons: molecular mechanisms and cellular consequences, Science 268, 239.
5. 2+ influx studies, J. Neurochem. 65, 1077.
6. Huffman, P.L., 1995. The effects of alcohol on excitatory amino acid receptor function, in: Handbook of Experimental Pharmacology, Vol. 114, The Pharmacology of Alcohol Abuse, ed. H. Kranzler (Springer, Heidelberg) p. 75.
7. Hoffman, P.L., C.S. Rabe, F. Moses and B. Tabakoff, 1989, N-methyl-D-aspartate and ethanol: inhibition of calcium flux and cyclic GMP production, J. Neurochem. 52, 1937.
8. Karcz-Kubicha, M. and S. Liljequist, 1995, Effects of post-ethanol administration of NMDA and non-NMDA receptor antagonists on the development of ethanol tolerance in C57B1 mice, Psychopharmacology 120, 49.
9. Levi, G., F. Aloisi, M.T. Ciotti and V. Gallo, 1984, Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures, Brain Res. 290, 77.
10. Lovinger, D.M., G. White and F.F. Weight, 1989, Ethanol inhibits NMDA-activated ion current in hippocampal neurons, Science 243, 1721.
11. Morgan, J.I. and T. Curran, 1991, Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun, Annu. Rev. Neurosci. 14, 421.
12. Nestler, E.J., B.T. Hope and K.L. Widnell, 1993, Drug addiction: a model for the molecular basis of neural plasticity, Neuron 11, 995.
13. 2+ channels, J. Neurochem. 65, 605.
14. Pennypacker, K.R., J.-S. Hong and M.K. KcMillian, 1995, Implications of prolonged expression of Fos-related antigens, Trends Pharmacol. Sci. 16, 317.
15. Szekely, A.M., M.L. Barbacchia and E. Costa, 1987, In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive receptors induces c-fos mRNA expression, Neuropharmacology 26, 1770.