The Binding Epitopes of Human CD16 (FcγRIII) Monoclonal Antibodies: Implications for Ligand Binding

Journal of Immunology

Volumn 157, Issue 4, 1996, Pages 1576-1581

  Tamm, Anu ^a   Schmidt, Reinhold E ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; EPITOPE; FC RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN G; LIGAND; MONOCLONAL ANTIBODY;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

ANTIBODIES, MONOCLONAL; DNA, COMPLEMENTARY; EPITOPES; IMMUNOGLOBULIN G; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS;

EID: 0030586658     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Unkeless, J. C., E. Scigliano, and V. H. Freedman. 1988. Structure and function of human and murine receptors for IgG. Annu. Rev. Immunol. 6:251.
2. Ravetch, J. V., and J.-P. Kinet. 1991. Fc receptors. Annu. Rev. Immunol. 9:457.
3. van de Winkel, J. G. J., and P. J. A. Capel. 1993. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today 14: 215.
4. Hulett, M. D., and P. M. Hogarth. 1994. Molecular basis of Fc receptor function. Adv. Immunol. 57:1.
5. Ravetch, J. V., and B. Perussia. 1989. Alternative membrane forms of FcγRIII (CD16) on human NK cells and neutrophils: cell-type specific expression of two genes which differ in single nucleotide substitutions. J. Exp. Med. 170:481.
6. Peltz, G. A., H. O. Grundy, R. V. Lebo, H. Yssel, G. S. Barsh, and K. W. Moore. 1989. Human FcγR, cloning, expression and identification of the chromosomal locus of two Fc receptors for IgG. Proc. Natl. Acad. Sci. USA 86:1013.
7. Kurosaki, T., and J. V. Ravetch. 1989. A single amino acid in the glycosyl phosphatidylinositol attachment determines the membrane topology of FcγRIII. Nature 342:805.
8. Lanier, L. L., S. Cwirla, G. Yu, R. Testi, and J. H. Phillips. 1989. Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid. Science 246:1611.
9. + cytotoxic T lymphocytes and natural killer cells. Eur. J. Immunol. 22:1635.
10. Lanier, L. L., G. Yu, and J. H. Phillips. 1989. Co-association of CD3-ζ with receptor for IgG Fc (CD16) on human natural killer cells. Nature 342:803.
11. Simmons, D., and B. Seed. 1988. The Fcγ receptor of natural killer cells is a phospholipid-linked membrane protein. Nature 333:568.
12. Werfel, T., P. Uciechowski, P. A. T. Tetteroo, R. Kurrle, H. Deicher, and R. E. Schmidt. 1989. Activation of cloned human natural killer cells via FcγRIII. J. Immunol. 142:1102.
13. Hundt, M., and R. E. Schmidt. 1992. The glycosylphosphatidylinositol-linked Fcγ receptor III represents the dominant receptor structure for immune complex activation of neutrophils. Eur. J. Immunol. 22:811.
14. Brunkhorst, B. A., G. Strohmeier, K. Lazarri, G. Weil, D. Melnick, H. B. Fleit, and E. R. Simons. 1992. Differential roles of FcγRII and FcγRIII in immune complex stimulation of human neutrophils. J. Biol. Chem. 267:20659.
15. Hoffmeyer, F., K. Witte, U. Gebhardt, and R. E. Schmidt. 1995. The low affinity FcγRIIA and FcγRIIIB on polymorphonuclear neutrophils are differentially regulated by CD45 phosphatase. J. Immunol. 155:4016.
16. Huizinga, T. W. J., M. Kleijer, D. Roos, and A. E. G. Kr. von dem Borne. 1989. Differences between FcRIII of human neutrophils and human K/NK lymphocytes in relation to NA antigen system. In Leukocyte Typing IV: White Cell Differentiation Antigens. W. Kapp et al., eds. Oxford University Press, Oxford, p. 582.
17. Scallon, B. J., E. Scigliano, V. H. Freedman, M. C. Miedel, Y.-C. E. Pan, J. C. Unkeless, and J. P. Kochan. 1989. A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms. Proc. Natl. Acad. Sci. USA 86:5079.
18. Ory, P. A., I. M. Goldstein, E. E. Kwoh, and S. B. Clarkson. 1989. Characterization of polymorphic forms of FcRIII on human neutrophils. J. Clin. Invest. 83:1676.
19. Edberg, J. C., P. B. Redecha, J. E. Salmon, and R. P. Kimberly. 1989. Isoforms with distinct allelic expression, extracellular domains and membrane linkages on polymorphonuclear and natural killer cells. J. Immunol. 143:1642.
20. Huizinga, T. W. J., M. Kleijer, P. A. T. Tetteroo, D. Roos, and A. E. G. Kr. von dem Borne. 1990. Biallelic neutrophil NA-antigen system is associated with a polymorphism on the phosphoinositol-linked Fcγ receptopr III. Blood 75:1211.
21. Hogg, N., and M. A. Horton. 1988. Myeloid antigens: new and previously defined clusters. In Leukocyte typing III: Human Myeloid and Hematopoietic Cells. A. McMichael, ed. Oxford University Press, Oxford, p. 576.
22. Schmidt, R. E., and B. Perussia. 1989. Cluster report: CD16. In Leukocyte Typing IV: White Cell Diferentiation Antigens. W. Kapp, B. Dörken, R. E. Schmidt, H. Stein, and A. E. G. Kr. Borne, eds. Oxford University Press, Oxford, p. 575.
23. Schmidt, R. E. 1995. CD16 cluster workshop report. In Leukocyte Typing V: White Cell Differentiation Antigens, Vol. 2. S. F. Schlossman, L. Boumsell, W. Gilks, J. M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. L. Silverstein, T. A. Springer, T. A. Tedder, and R. F. Todd, eds. Oxford University Press, Oxford, p. 805.
24. Salmon, J. E., J. C. Edberg, R. P. Kimberly, E. Mensa, and R. Ryan. 1990. Fcγ receptor III on human neutrophils: allelic variants have functionally distinct capabilities. J. Clin. Invest. 85:1287.
25. Trounstine, M. L., G. A. Peltz, H. Yssel, T. W. J. Huizinga, A. E. G. Kr. von dem Borne, H. Spits, and K. W. Moore. 1990. Reactivity of cloned, expressed human FcγRIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of FcγIII. Int. Immunol. 2:303.
26. Fleit, H. B., M. Kuhnle, and C. D. Kobasiuk. 1989. Monoclonal antibodies detect antigenic differences in FcγRIII on neutrophils and natural killer cells. In Leukocyte Typing IV: White Cell Differentiation Antigens. W. Kapp, B. Dörken, R. E. Schmidt, H. Stein, and A. E. G. Kr. Borne, eds. Oxford University Press, Oxford, p. 579.
27. Perussia, B., M. A. Cassatella, I. Anegón, and G. Trinchieri. 1989. Antigenic and functional properties of two low-affinity FcγR types: FcγRIII (CD16) on natural killer cells and polymorphonuclear neutrophils and FcγII (CDw32) on neutrophils and B-cells. In Leukocyte Typing IV: White Cell Differentiation Antigens. W. Kapp, B. Dörken, R. E. Schmidt, H. Stein, A. E. G. Kr. Borne, eds. Oxford University Press, Oxford, p. 591.
28. Hibbs, M. L., M. Tolvanen, and O. Carpén. 1994. Membrane-proximal Ig-like domain of FcγRIII (CD16) contains residues critical for ligand binding. J. Immunol. 152:4466.
29. Tamm, A., A. Kister, K. U. Nolte, J. E. Gessner, and R. E. Schmidt. 1996. The IgG binding site of human FcγRIIIB receptor involves CC′ and FG loops of the membrane-proximal domain. J. Biol. Chem. 271:3659.
30. Branden, C., and J. Tooze. 1991. Introduction to Protein Structure. Garland Publishing, Inc., New York.
31. Fleit, H. B., S. D. Wright, and J. C. Unkeless. 1982. Human neutrophil Fcγ receptor distribution and structure. Proc. Natl. Acad. Sci. USA 79:3275.
32. Werner, G., A. E. G. Kr. von dem Borne, M. J. E. Bos, J. F. Tromp, C. M. van der Plas-van Dalen, F. J. Visser, C. P. Engelfriet, and P. A. T. Tetteroo, T. 1986. Localization of the human NA1 alloantigen on neutrophil Fc-γ-receptors. In Leukocyte Typing II. E. L. Reinherz, ed. Springer-Verlag, New York, p. 109.
33. Nevot, L., M. A. T. Cabrera, C. Huelin C., F. Ruiz-Cabello, and Carrido F. 1988. A study of mAb GRMI which reacts with natural killer cells and granulocytes. In Leukocyte Typing III: Human Myeloid and Hematopoietic Cells. A. McMichael, ed. Oxford University Press, Oxford, p. 707.
34. Graham, F. L. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59.
35. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
36. De Haas, M., M. Kleijer, D. Roos, and A. E. G. Kr. von dem Borne. 1995. Characterization of mAb of the CD16 cluster and six newly generated CD16 mAb. In Leukocyte Typing V: White Cell Differentiation Antigens, Vol. 2. S. F. Schlossman, L. Boumsell, W. Gilks, J. M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. L. Silverstein, T. A. Springer, T. A. Tedder, and R. F. Todd, eds. Oxford University Press, Oxford, p. 811.
37. De Haas, M., H. R. Koene, M. Kleijer, E. de Vries, S. Simsek, M. J. D. van Tol, D. Roos, and A. E. G. Kr. von dem Borne. 1996. A triallelic Fγ receptor type IIIA polymorphism influences the binding of human IgG by NK cell FcγRIIIa. J. Immunol. 156:2948.
38. Kimberly, R. P., N. J. Tappe, L. T. Merriam, P. B. Redecha, J. C. Edberg, S. Schwartzman, and J. E. Valinsky. 1989. Carbohydrates on human Fcγ receptors: independence of the classical IgG and nonclassical lectin-binding sites on human FcγRIII expressed on neutrophils. J. Immunol. 142:3923.
39. Hulett, M. D., E. Witort, R. I. Brinkworth, I. F. C. McKenzie, and P. M. Hogarth. 1995. Multiple regions of human FcγRII (CD32) contribute to the binding of IgG. J. Biol. Chem. 270:21188.
40. Hulett, M. D., E. Witort, R. I. Brinkworth, I. F. C. McKenzie, and P. M. Hogarth. 1994. Identification of the IgG binding site of the human low affinity receptor for IgG FcγRII: enhancement and ablation of binding by site-directed mutagenesis. J. Biol. Chem. 269:15287.
41. Kraulis, P. J. 1991. MOLSCRIPT: a program to produce both detailed and schematic plots for protein structures. J. Appl. Crystallogr. 24:946.
42. Bacon, D. J., and W. F. Anderson. 1988. A fast algorithm for rendering spacefilling molecule pictures. J. Mol. Graph. 6:261.