Cholinergic deafferentation enhances rat hippocampal pyramidal neuron responsiveness to locally applied nicotine

Brain Research

Volumn 727, Issue 1-2, 1996, Pages 217-220

  Frazier, C J ^a   Rollins, Y D ^a   Hall, M E ^a   Young, D A ^a   Rose, G M ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; Cytisine; Hippocampus; Nicotine; Pyramidal cell; Septal lesion; Bungarotoxin

Indexed keywords

ALPHA BUNGAROTOXIN; CYTISINE; NICOTINE; PENTOBARBITAL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECEPTOR BINDING; SEPTUM NUCLEUS;

EID: 0030586335     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00402-7     Document Type: Article

References (20)

1. [1] Alkondon, M. and Albuquerque, E.X., Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes, J. Pharmacol. Exp. Ther., 265 (1993) 1455-1473.
2. [2] Bartus, R.T., Dean III, R.L., Beer, B. and Lippa, A.S., The cholinergic hypothesis of geriatric memory dysfunction, Science, 217 (1982) 408-417.
3. [3] Bird, S.J. and Aghajanian, G.K., Denervation supersensitivity in the cholinergic septo-hippocampal pathway: a microiontophoretic study, Brain Res., 100 (1975) 355-370.
4. [4] Cannon, W.B., A law of denervation, Am. J. Med. Sci., 198 (1939) 737-750.
5. [5] Engstrom, D.A., Bickford-Wimer, P.C., de la Garza, R., Young, D. and Rose, G.M., Increased responsiveness of hippocampal pyramidal neurons to nicotine in aged. learning-impaired rats, Neurobiol.Aging, 14 (1993) 259-266.
6. [6] Fischer. W., Gage, F.H. and Björklund, A., Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. Eur. J. Neurosci., 1 (1989) 34-45.
7. [7] Fonnum, F., A rapid radiochemical method for the determination of choline acetyitransferase. J. Neurochem., 24 (1975) 407-409.
8. [8] Freund, R.K., Jungschaffer, D.A., Collins, A.C. and Wehner, J.M., Evidence for modulation of GABAergic neurotransmission by nicotine, Brain Res., 453 (1988) 215-220.
9. [9] Hall, M., Zerbe, L., Leonard, S. and Freedman, R., Characterization of [3H]cytisine binding to human brain membrane preparations, Brain Res., 600 (1993) 127-133.
10. [10] Krnjevic, K., Ropert, N. and Casullo, J., Septohippocampal disinhibition. Brain Res., 438(1988) 182-192.
11. [11] Laird, N.M. and Mosteller, F., Some statistical methods for combining experimental results. Int. J. Technol. Assess. Health Care, 6 (1990) 5-30.
12. 3H]cytisine/nicotinic binding sites and presynaptic nicotinic receptor function following fimbrial transections, Neuroscience, 60 (1994) 293-298.
13. [13] Le Novere, N. and Changeux, J.-P., Molecular evolution of the nicotonic acetylcholine receptor: an example of multigene family in excitable cells, J. Mol. Evol., 40 (1995) 155-172.
14. [14] Marks, M.J. and Collins, A.C., Characterization of nicotine binding in mouse brain and comparison with the binding of α-bungarotoxin and quinuclidinyl benzilate, Mol. Pharmacol., 22 (1982) 554-564.
15. [15] Marks, M.J., Grady, S.R. and Collins, A.C., Downregulation of nicotinic receptor function after chronic nicotine infusion, J. Pharmacol. Exp. Ther., 266 (1993) 1268-1276.
16. [16] Potier, B., Krzywkowski, P., Lamour, Y. and Dutar, P., Loss of calbindin-immunoreactivity in CA1 hippocampal stratum radiatum and stratum lacunosum-moleculare interneurons in the aged rat, Brain Res., 661 (1994) 181-188.
17. [17] Rose, G.M. and Engstrom, D.A., Differential effect of aging on hippocampal pyramidal cell responses to muscarine and nicotine. In E.M. Meyer, J.W. Simpkins, J. Yamamoto and F.T. Crews (Eds.), Treatment of Dementias: A New Generation of Progress, Plenum Press, New York, 1992, pp. 57-73.
18. [18] Smith, T.D., Gallagher, M. and Leslie, F.M., Cholinergic binding sites in rat brain: analysis by age and cognitive status, Neurobiol. Aging, 16 (1995) 161-173.
19. [19] Thorne, B. and Potter, P.E., Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function, Brain Res. Bull., 38 (1995) 121-127.
20. [20] Zola-Morgan, S., Squire, L.R. and Amaral, D.G., Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus, J. Neurosci., 6(10) (1986) 2950-2967.