Guinea pig blood: A model for the pharmacologic modulation of the GPIb/IX-VWF axis

Thrombosis Research

Volumn 83, Issue 2, 1996, Pages 127-136

  André, Patrick ^a,b,e   Hainaud, P ^b   Sollier, C Bal Dit ^b   Drouet, V ^b   Garfinkel, L I ^c   Uzan, A ^d   Caen, J P ^b   Drouet, L O ^a,b  

^a INSERM   (France)

^b Institut des Vaisseaux et du Sang   (France)

^c Bio Technology General   (Israel)

^d SANOFI   (France)

^e HÔPITAL LARIBOISIÈRE   (France)

Author keywords

GPIb IX; Guinea pig blood; Thrombosis; vWF

Indexed keywords

ANTICOAGULANT AGENT; COLLAGEN TYPE 3; GLYCOPROTEIN IB; RG 12986; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; GUINEA PIG; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS; THROMBOCYTE ADHESION; THROMBOSIS; THROMBOSIS PREVENTION;

EID: 0030586152     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-3848(96)00113-2     Document Type: Article

References (9)

1. 1. BLOOM, A.L., GIDDINGS, J.C., and WILKE, C.J. Factor VIII on the vascular intima: possible importance in hemostasis and thrombosis. Nature 241, 217-219, 1973.
2. 2. JAFFE, E.A., HOYER, L.W., and NACHMAN, R.L. Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest 52, 2757-2764, 1973.
3. 3. NACHMAN, R.L., LEVINE, R., and JAFFE, E.A. Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J Clin Invest 60, 914-921, 1977.
4. 4. SPORN, L.A., CHAVIN, S.I., MARDER, V.J., and WAGNER, D.D. Biosynthesis of VW protein by human megakaryocytes. J Clin Invest 76, 1102-1106, 1985.
5. 5. WEISS, H.J., TURITTO, V.T., and BAUMGARTNER, H.R. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood, I: shear rate-dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome. J Lab Clin Med 92, 750-764, 1978.
6. 6. WEISS, H.J.,TSCHOPP, T.B., BAUMGARTNER, H.R., SUSSMAN, I.I., JOHNSON, M.M., and EGAN, J.J. Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium: Further implications on the role of the von Willebrand factor in hemostasis. Am J Med 57, 920-925, 1974.
7. 7. WEISS, H.J., HAWIGER, J., RUGGERI, Z.M., TURITTO, V.T., THIAGARAJAN, P., and HOFFMAN, T. Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotem IIb-IIIa complex at high shear rate. J Clin Invest 83, 288-197, 1989.
8. 8. FUJIMURA, Y., TITANI, K., HOLLAND, L.Z., RUSSEL, S.R., ROBERTS, J.R., ELDER, J.H., RUGGERI, Z.M., and ZIMMERMAN, T.S. von Willebrand factor: a reduced and alkylated 52/48-kDa fragment beginning at amino residue 449 contains the domain interacting with platelet glycoprotem Ib. J Biol Chem 261, 381-385, 1986.
9. 9. MOHRI, H., FUJIMURA, Y., SHIMA, M., YOSHIOKA, A., HOUGHTEN, R.A., RUGGERI, Z.M., and ZIMMERMAN, TS. Structure of the von Willebrand factor domain interacting with glycoprotein Ib. J Biol Chem 263, 17901-17904, 1988.