Gene overexpression reveals alternative mechanisms that induce GCN4 mRNA translation

Gene

Volumn 179, Issue 2, 1996, Pages 271-277

  Tavernarakis, Nektarios ^a,b,c   Alexandraki, Despina ^a,b   Liodis, Peter ^a,b   Tzamarias, Dimitris ^a   Thireos, George ^a  

^a INSTITUTE OF COMPUTER SCIENCE   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Amino acid starvation; eIF 2; GCN2; NME1; Phosphorylation; TPK2; tRNA

Indexed keywords

INITIATION FACTOR 2; MESSENGER RNA;

ARTICLE; GENE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; TRANSLATION INITIATION;

DNA-BINDING PROTEINS; ENDORIBONUCLEASES; EUKARYOTIC INITIATION FACTOR-2; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, SUPPRESSOR; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; RNA, FUNGAL; RNA, MESSENGER; RNA, TRANSFER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE;

SACCHAROMYCES CEREVISIAE;

EID: 0030583733     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(96)00379-4     Document Type: Article

References (25)

1. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (1987) Current Protocols In Molecular Biology. John Wiley, New York.
2. val: homology blocks occur in the vicinity of different tRNA genes. EMBO J. 1, 291-295.
3. Chu, S., Archer, R.H., Zengel, J.M. and Lindahl, L. (1994) The RNA of RNase MRP is required for normal processing of ribosomal RNA. Proc. Natl. Acad. Sci. USA. 91, 659-663.
4. Cigan, A.M., Pabich, E.K., Feng, L. and Donahue, T.F. (1989) Yeast translation initiation suppressor sui2 encodes the α subunit of eukaryotic initiation factor 2 and shares sequence identity with the human α subunit. Proc. Natl. Acad. Sci. USA 86, 2784-2788.
5. Dever, T.E., Feng, L., Wek, R.C., Cigan, A.M., Donahue, T.D. and Hinnebusch A.G. (1992) Phosphorylation of the initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68, 585-596.
6. Donahue, T.F., Cigan, A.M., Pabich E.K., and Valavicius, B.C. (1988) Mutations at a Zn(II) finger motif in the yeast eIF-2β gene alter ribosomal start-site selection during the scanning process. Cell 54, 621-632.
7. Driscoll Penn, M., Galgoci, B. and Greer, H. (1983) Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast. Proc. Natl. Acad. Sci. USA 80, 2704-2710.
8. Engelberg, D., Klein, C., Martinetto, H., Struhl, K, and Karin, M. (1994) The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell 77, 381-390.
9. Hinnebusch, A.G. (1990) Transcriptional and translational regulation of gene expression in the general control of aminoacid biosynthesis in Saccharomyces cerevisiae. Progress in Nucleic Acid Res. Mol. Biol. 38, 195-240.
10. Jones, E.W. and Fink, G.R. (1985) Regulation of amino acid and nucleotide biosynthesis in yeast. Microbiol. Rev. 5, 181-293.
11. Kanazawa, S., Driscoll, M. and Struhl, K. (1988) ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol. Cell. Biol. 8, 664-673.
12. Klopotowski, T. and Wiater, A. (1965) Synergism of aminotriazole and phosphate on the inhibition of yeast imidazoleglycerol-phosphate dehydratase. Arch. Biochem. Biophys. 112, 562-566.
13. Krupitza, G. and Thireos, G. (1990) Translational activation of GCN4 mRNA in a cell-free system is triggered by uncharged tRNAs. Mol. Cell. Biol. 10, 4375-4378.
14. Mueller, P.P. and Hinnebusch, A.G. (1986) Multiple upstream AUG codons mediate translational control of GCN4. Cell 45, 201-207.
15. Normanly, J. and Abelson, J. (1989) tRNA identity. Annu. Rev. Biochem. 58, 1029-1049.
16. Rotenberg, M.O., Moritz, M. and Woolford Jr., J.L. (1988) Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Genes Dev. 2, 160-172.
17. Roussou, I., Thireos, G. and Hauge, B.M. (1988) Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase. Mol. Cell. Biol. 8, 2132-2139.
18. Schmitt, M.E. and Clayton, D.A. (1992) Yeast site-specific ribonucleo-protein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev. 6, 1975-1985.
19. Thevelein, J.M. (1994) Signal transduction in yeast. Yeast 10, 1753-1790.
20. Toda, T., Cameron, S., Sass, P., Zoller, M. and Wigler, M. (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50, 277-287.
21. Tzamarias, D., Alexandraki, D. and Thireos, G. (1986) Multiple cis-acting elements modulate the translational efficiency of GCN4 mRNA in yeast. Proc. Natl. Acad. Sci. USA 83, 4849-4853.
22. Tzamarias, D., Roussou, I. and Thireos, G. (1989) Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation. Cell 57, 947-954.
23. Vazquez de Aldana, C., Wek, R., San Segundo, P., Truesdell, A. and Hinnebusch, A. (1994) Multicopy tRNA genes functionally suppress mutations in yeast eIF-2α kinase GCN2: evidence for separate pathways coupling gcn4 expression to uncharged tRNA. Mol. Cell. Biol. 14, 7920-7932.
24. Wek, R.C., Cannon, J.F., Dever, T.E. and Hinnebusch, A.G. (1992) Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2α kinase GCN2. Mol. Cell. Biol. 12, 5700-5710.
25. Williams, N.P., Hinnebusch, A.G. and Donahue, T.F. ( 1989) Mutations in the structural genes for eukaryotic initiation factors 2β and 2α of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA. Proc. Acad. Sci. USA 86, 7515-7519.