Consumption of a high dietary dose of monosodium glutamate fails to affect extracellular glutamate levels in the hypothalamic arcuate nucleus of adult rats

Brain Research

Volumn 736, Issue 1-2, 1996, Pages 76-81

  Bogdanov, Mikhail B ^a   Tjurmina, Olga A ^a   Wurtman, Richard J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

arcuate nucleus of hypothalamus; extracellular level; feeding; glutamate; microdialysis; plasma level

Indexed keywords

GLUTAMATE SODIUM; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030583652     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00679-8     Document Type: Article

References (23)

1. [1] Airoldi, L., Bizzi, A., Salmona, M. and Garratini, S., Attempts to establish the safety margin for neurotoxicity of monosodium glutamate. In L.J. Filer, S. Garratini, MR. Kare, W.A. Reynolds and R.J. Wurtman (Eds.), Glutamic Acid: Advances in Biochemistry and Physiology, Raven Press, New York, 1979, pp. 321-331.
2. [2] Bizzi, A., Veneroni, E., Salmona M. and Garratini, S., Kinetics on monosodium glutamate in relation to its neurotoxicity, Toxicol. Lett., 1 (1977) 123-130.
3. [3] Bogdanov, M.B. and Wurtman, R.J., Effects of systemic or oral ad libitum monosodium glutamate administration on striatal glutamate release, as measured using microdialysis in freely moving rats, Brain Res., 660 (1994) 337-340.
4. [4] Caccia, S., Garattini, S., Ghezzi, P. and Zanini, M.G., Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats, Toxicol. Lett., 10 (1982) 169-175.
5. [5] Donzanti, B.A. and Yamamoto, B.K., An improved and rapid HPLC-EC metod for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates, Life Sci., 43 (1988) 913-922.
6. [6] Fonnum, F., Glutamate: a neurotransmitter in mammalian brain, J. Neurochem., 42 (1984) 1-11.
7. [7] Garattini, S., Evaluation of the neurotoxic effects of glutamic acid, In R.J. Wurtman and J.J. Wurtman (Eds.), Nutrition and the Brain, Raven Press, New York, 1979, pp. 79-124.
8. [8] Heywood, R., James, R.W. and Worden, A.N., The ad libitum feeding of monosodium glutamate to wealning mice, Toxicol. Lett., 1 (1977) 151-155.
9. [9] Hutchison, H.T., Eisenberg, H.M. and Haber, B., High-affinity transport of glutamate in rat brain microvessels, Exp. Neurol., 87 (1985) 260-269.
10. [10] Liebshutz, J., Airoldi, L., Brownstein, M.J., Chinn, N.G. and Wurtman, R.J., Regional distribution of endogenous and parenteral glutamate, aspartate and glutamine in rat brain, Biochem. Pharmacol., 26 (1977) 443-446.
11. [11] Lucas, D.R. and Newhouse, J.P., The toxic effect of sodium L-glutamate on the inner layers of the retina. AMA Arch. Opthalmol., 58 (1957) 193-201.
12. [12] McCall, A., Glaeser, B.S., Millington, W. and Wurtman, R.J., Monosodium glutamate neurotoxicity, hyperosmolarity and blood-barrier disfunction, Neurobehav. Toxicol., 1 (1979) 279-283.
13. [13] Merchenthaler, I., Neurons with access to the general circulation in the central nervous system of the rat: a retrograde tracing study with fluoro-gold, Neuroscience, 44 (1991) 655-662.
14. [14] Monno, A., Vezzani, A., Bastine, A., Salmona, M. and Garattini, S., Extracellular glutamate levels in the hypothalamus and hippocampus of rats after acute or chronic oral intake of monosodium glutamate, Neurosci. Lett., 193 (1995) 45-48.
15. [15] O'Hara Y. and Takasaki, Y., Pelatiobship between plasma glutamate levels and hypothalamic lesions in rodents, Toxicol. Lett., 4 (1979) 499-505.
16. [16] Oldendorf, W. and Szabo, J., Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am. J. Physiol., 230 (1976) 94-98.
17. [17] Olney, J.W., Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate, Science, 164 (1969) 719-721.
18. [18] Olney, J.W., Excitotoxic amino acids: Research applications and safety implications, In L.J. Filer, S. Garratini, M.R. Kare, W.A. Reynolds and R.J. Wurtman (Eds.), Glutamic Acid: Advances in Biochemistry and Physiology, Raven Press, New York, 1979, pp. 287-319.
19. [19] Pardridge, W.M., Regulation of amino acids availability to brain: Selective control mechanisms for glutamate, In L.J. Filer, S. Garratini, M.R. Kare, W.A. Reynolds and R.J. Wurtman (Eds.), Glutamic Acid: Advances in Biochemistry and Physiology, Raven Press, New York, 1979, pp. 125-138.
20. [20] Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1986.
21. [21] Peng, Y., Gubin, J., Harper, A.E., Vavich, M.G. and Kemmer, A.R., Food intake regulation: Amino acid toxicity and changes in rat brain and plasma amino acids, J. Nutr., 103 (1973) 608-617.
22. [22] Torii, K., Takasaki, Y., Iwata, S. and Wurtman, R.J., Changes in blood osmolarity, electrolytes and metabolites among adult rats treated with a neurotoxic dose of MSG, Life Sci., 28 (1981) 2855-2864.
23. [23] Westergen, I., Nystrom, B., Hamberger, A. and Johansson, B., Intracerebral dialysis and blood-brain barrier, J. Neurochem., 64 (1995) 229-234.