Reactivity of the one-electron reduction product from nifedipine with relevant biological targets

Chemico-Biological Interactions

Volumn 101, Issue 2, 1996, Pages 89-101

  Núñez Vergara, Luis J ^a   Navarrete Encina, P A ^a   Ortiz, M E ^a   Bollo, S ^a   Squella, J A ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

cyclic voltammetry; endobiotics; nifedipine; xenobiotics

Indexed keywords

ACETYLCYSTEINE; ADENINE; ANION; CAPTOPRIL; FREE RADICAL; GLUTATHIONE; MERCAPTAMINE; NIFEDIPINE; PENICILLAMINE; URACIL;

ARTICLE; CHEMICAL REACTION; COMPUTER SIMULATION; CYCLIC POTENTIOMETRY; ELECTROCHEMISTRY;

EID: 0030583310     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(96)03714-3     Document Type: Article

References (28)

1. [1] J. Bou, J. Llenas and R. Massingham, Calcium entry blocking drugs, 'Calcium antagonists' and vascular smooth muscle function, J. Auton. Pharmacol., 3 (1983) 219-232.
2. [2] T. Godfraind, R. Miller and M. Wibo, Calcium antagonists and calcium entry blockade, Pharmacol. Rev., 38 (1986) 321-416.
3. [3] J.A. Squella, J. Mosre, M. Blázquez and L.J. Núñez-Vergara, Cyclic voltammetric study of the nitro radical anion from nitrendipine generated electrochemically, J. Electroanal. Chem., 319 (1991) 177-184.
4. [4] L.J. Núñez-Vergara, S. Bollo, A.F. Alvarez, M. Blázquez and J.A. Squella, Nitro radical anion formation from nimodipine, J. Electroanal. Chem., 345 (1993) 121-133
5. [5] J.A. Squella, S. Bollo, J. de la Fuente and L.J. Núñez-Vergara, Electrochemical study of the nitro radical anion from nicardipine: kinetic parameters and its interaction with glutathione, Bioelectrochem. Bioenerg., 34 (1994) 13-18.
6. [6] L.J. Núñez-Vergara, F. Garcia, M.M. Domínguez, J. de la Fuente and J.A. Squella, In situ reactivity of the electrochemically generated nitro radical anion from nitrendipine with glutathione, adenine and uracil, J. Electroanal. Chem., 381 (1995) 215-219.
7. [7] J.A. Squella, C. Solabarrieta and L.J. Núñez-Vergara, A nitro radical anion formation from nifedipine: an electrochemical approach, Chem.-Biol. Interact., 89 (1993) 197-205.
8. [8] D.A. Rowley, R.C. Knight, I.M. Skolimowski and D.I. Edwards, The relationship between misonidazole cytotoxicity and base composition of DNA, Biochem. Pharmacol., 29 (1980) 2095-2098.
9. [9] R.C. Knight, I.M. Skolimowski and D.I. Edwards, The interaction of reduced metronidazole with DNA, Biochem. Pharmacol., 27 (1978) 2089-2093.
10. [10] P.J. Declerck and C.J. De Ranter, Polarographic evidence for the interaction of reduced nitroimidazole derivatives with DNA bases, J. Chem. Soc. Faraday Trans. I, 83 (1987) 257-265.
11. [11] J.H. Tocher and D.I. Edwards. Evidence for the direct interaction of reduced metronidazole derivatives with DNA bases, Biochem. Pharmacol., 48 (1994) 1089-1094.
12. [12] J.E. Biaglow, M.E. Varnes, E.R. Repp, E.P. Clark, S. Tuttle and K.D. Held, Cellular protection against damage by hydroperoxides: role of glutathione, in: M.G. Simic, K.A. Taylor, J.F. Ward and CI. von Sontag (Eds.), Oxygen Radicals in Biology and Medicine, Plenum Press, NY, 1988, pp. 567-573.
13. [13] H. Sies and E. Cadenas, Biological basis of detoxification of oxygen free radicals, in: J. Caldwell and W. Jacoby (Eds.), Biological Basis of Detoxification, Academic Press, NY, 1983, pp. 181-211.
14. [14] G.E. Adams and I.J, Stradford, Hypoxia-mediated nitro-heterocyclic drugs in radio- and chemotherapy of cancer, Biochem. Pharmacol., 35 (1986) 71-76.
15. [15] M. Spotheim-Maurizot, F. Garnier, C. Kieda, R. Sabattier and M. Charlier, N-acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons, Radiat. Environ. Biophys., 32 (1993) 337-343.
16. [16] D. Bagchi, R. Prasad and D.K. Das, Direct scavenging of free radicals by captopril, an angiotensin converting enzyme inhibitor, Biochem. Biophys. Res. Commun., 158 (1989) 52-57.
17. [17] S. Zheng, G.L. Newton, G. Gonock, R.C. Fahey and J.F. Ward, Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA, Radiat. Res., 114 (1988) 11-27.
18. [18] A.G. González, F. Pablos and A.G. Asuero, Correction factors for the glass electrode revisited, Talanta, 39 (1992) 91.
19. [19] A.G. Asuero, M.A Herrador and A.G. González, Estimation of pH and autoprotolysis constants in mixtures of aliphatic amides with eater: medium effect on the 4-aminoazobenzene system, Talanta, 40 (1993) 479-484.
20. [20] R.S. Nicholson and I. Shain, A simple procedure to calculate the current ratio, Anal. Chem., 36 (1964) 1406.
21. [21] R.S. Nicholson and I. Shain, Theory of stationary electrode polarography, single scan and cyclic methods applied to reversible, irreversible and kinetic systems, Anal. Chem., 36 (1964) 706-723.
22. [22] G. Bontempelli, F. Magno, G. Mazzochin and R. Seeger, Linear sweep and cyclic voltammetry, Annal. Chim., 79 (1989) 138.
23. [23] M. Olmstead, R. Hamilton and R.S. Nicholson, Theory of cyclic voltammetry for a dimerization reaction initiated electrochemically, Anal. Chem., 41 (1969) 260-267.
24. [24] M. Rudolph, D.P. Reddy and S.W. Feldberg, A simulator for cyclic voltammetric responses, Anal. Chem., 66 (1994) 589A-600A.
25. [25] H. Lund and M.M. Baizer, Organic Electrochemistry, 3rd edn., Marcel Dekker, NY, 1991, pp. 307.
26. [26] B. Kwiatek and M.K. Kalinowski, Electrochemical reduction of substituted nitrobenzenes in N,N-dimethylformamide containing proton donating agents. Effect of the double layer on the basicity of the nitro group, J. Electroanal. Chem., 226 (1987) 61-67.
27. [27] The Merck Index, in: S. Budavari (Ed.), Merck & Co. Publishers, NJ, 1989, pp. 4373.
28. [28] A. Goldstein, L. Aronow and S.M. Kalman, Principles of Drug Action. The Basis of Pharmacology, Harper & Row Publishers, NY, 1968, pp. 26.