Effects of indomethacin on cerebral blood flow and oxygen metabolism: A positron emission tomographic investigation in the anaesthetized baboon

Neuroscience Letters

Volumn 220, Issue 2, 1996, Pages 137-141

  Schumann, Pascale ^a,d   Touzani, Omar ^a,d   Young, Alan R ^b,d   Verard, Laurent ^a,d   Morello, Rémi ^c   MacKenzie, Eric T ^a,d  

^a UNIVERSITÉ DE CAEN   (France)

^b INSERM   (France)

^c CAEN UNIVERSITY HOSPITAL   (France)

^d GIP CYCERON   (France)

Author keywords

Cerebral blood flow; Cerebral circulation; Cerebral oxygen metabolism; Indomethacin; Non human primate; Positron emission tomography; Prostaglandins

Indexed keywords

INDOMETACIN; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BRAIN BLOOD FLOW; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; INDOMETHACIN; OXYGEN; PAPIO; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030582730     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13210-9     Document Type: Article

References (29)

1. [1] Abdel-Halim, M.S., Sjöquist, B. and Änggäard, E., Inhibition of prostaglandin synthesis in rat brain, Acta Pharmacol. Toxicol., 43 (1978) 266-272.
2. [2] Benders, M.J.N.L., Dorrepaal, C., van der Bor, M. and van Bel, F., Acute effects of indomethacin on cerebral hemodynamics and oxygenation, Biol. Neonate, 68 (1995) 91-99.
3. [3] Brandt, L., Ljunggren, B., Andersson, K.E., Hindfelt, B. and Uski, T., Effect of indomethacin and prostacyclin on isolated human pial arteries contracted by CSF from patients with aneurysmal SAH, J. Neurosurg., 55 (1981) 877-883.
4. [4] Chemtob, B., Beharry, K., Barna, T., Varma, D.R. and Aranda, J.V., Differences in the effects in the newborn piglet of various nonsteroidal anti-inflammatory drugs on cerebral blood flow but not on cerebrovascular prostaglandins, Pediatr. Res., 30 (1991) 106-111.
5. [5] Coyle, M.G., Oh, W., Petersson, K.H. and Stonestreet, B.S., Effects of indomethacin on brain blood flow, cerebral metabolism and sagittal sinus prostanoids after hypoxia, Am. J. Physiol.., 269 (1995) H1450-H1459.
6. [6] Coyle, M.G., Oh, W. and Stonestreet, B.S., Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets, Am. J. Physiol., 264 (1993) H141-H149.
7. [7] Dahlgren, N., Nilsson, B., Sakabe, T. and Siesjö, B.K., The effect of indomethacin on cerebral blood flow and oxygen consumption in the rat at normal and increased carbon dioxide tensions, Acta Physiol. Scand., 111 (1981) 475-485.
8. 2-stimulated cerebral blood flow in man, Gen. Pharmacol., 14 (1983) 179-180.
9. 15O and positron emission tomography: theory, procedure and normal values, J. Comput. Assist. Tomogr., 4 (1980) 727-736.
10. [10] Hucker, H.B., Zacchei, A.G., Cox, S.V., Brodie, D.A. and Cantwell, N.H.R., Studies on the absorption, distribution and excretion of indomethacin in various species, J. Pharmacol. Exp. Ther., 153 (1966) 237-249.
11. [11] Jensen, K., Kjaergaard, S., Malte, E., Bünemann, L., Therkelsen, K. and Knudsen, F., Effects of graduated intravenous and standard rectal doses of indomethacin on cerebral blood flow in healthy volunteers, J. Neurosurg. Anaesth., 8 (1996) 111-116.
12. [12] Kantor, H.S. and Hampton, M., Indomethacin in submicromolar concentrations inhibits cyclic-AMP-dependent protein kinase, Nature. 276 (1978) 841-842.
13. [13] Lou, H.C., Edvinsson, L. and MacKenzie, E.T., The concept of coupling blood flow to brain function: revision required?, Ann. Neurol., 22 (1987) 289-297.
14. [14] Mazoyer, B., Trebossen, R., Shoukroun, C., Verrey, B., Syrota, A., Vacher, J., Lemasson, P., Monnet, O., Bouvier, A. and Lecomte, J.L., Physical characteristics of TTV03, a new high spatial resolution time-of-flight positron tomograph, IEEE Trans. Nucl. Sci., 37 (1990) 778-782.
15. [15] McCulloch, J., Kelly, P.A.T., Grome, J.J. and Pickard, J.D., Local cerebral circulatory and metabolic effects of indomethacin, Am. J. Physiol., 243 (1982) H416-H423.
16. [16] Nowicki, J.P., Jourdain, D. and MacKenzie, E.T., NADH fluorescence in vivo: changes in cerebral oxidative metabolism and perfusion induced by pentobarbital, indomethacin, and salicylate. J. Cerebral Blood Flow Metab., 7 (1987) 280-288.
17. 15O, Eur. J. Nucl. Med., 10 (1985) 387-391.
18. [18] Parfenova, H., Hsu, P. and Leffler, C.W., Dilator prostanoid-induced cyclic AMP formation and release by cerebral microvascular smooth muscle cells: inhibition by indomethacin, J. Pharmacol. Exp. Ther., 272 (1995) 44-52.
19. [19] Pickard, J.D., Role of prostaglandins and arachidonic acid derivatives in the coupling of cerebral blood flow to metabolism, J. Cerebral Blood Flow Metab., 1 (1981) 361-384.
20. [20] Pickard, J.D., Kelly, P.A.T., Grome, J.J. and McCulloch, J., Prostaglandin mechanisms and the relationship between local cerebral glucose utilization and local blood flow, J. Cerebral Blood Flow Metab., 1 (1981) S291-S292.
21. [21] Pickard, J.D., MacDonell, A., MacKenzie, E.T. and Harper, M.A., Response of the cerebral circulation in baboons to changing perfusion pressure after indomethacin, Circ. Res., 40 (1977) 198-203.
22. [22] Pickard, J.D. and MacKenzie, E.T., Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide, Nature (New Biol.), 245 (1973) 187-188.
23. [23] Pickard, J.D., Tamura, A., Stewart, M., McGeorge, A. and Fitch, W., Prostacyclin, indomethacin and the cerebral circulation, Brain Res., 197 (1980) 425-431.
24. [24] Pourcyrous, M., Leffler, C.W., Bada, H.S., Korones, S.B. and Busija, D.W., Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose, Pediatr. Res., 34 (1993) 366-369.
25. [25] Riche, D., Hantraye, P., Guibert, B., Naquet, R., Loc'h, C., Mazière, B. and Mazière, M., Anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography, Brain Res. Bull., 20 (1988) 283-301.
26. [26] Schaad, N.C., Magistretti, P.J. and Schorderet, M., Prostanoids and their role in cell-cell interactions in the central nervous system, Neurochem. Int., 3 (1991) 303-322.
27. [27] van Bel, F., van Zoeren, D., Houdkamp, E. and Berger, H.M., Is there a relationship between indomethacin-induced reduction in neonatal cerebral blood flow velocity and prostaglandin production?, Dev. Pharmacol. Ther., 20 (1993) 45-53.
28. [28] Wang, Q., Paulson, O.B. and Lassen, N.A., Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia?, J. Cerebral Blood Flow Metab., 13 (1993) 724-727.
29. [29] Woods, R.P., Mazziotta, J.C. and Cherry, S.R., MRI-PET registration with automated algorithm, J. Comput. Assist. Tomogr., 17 (1993) 536-546.