Age and gender differences in hepatic ascorbic acid concentrations and NADPH dehydroascorbic acid reductase activity

Mechanisms of Ageing and Development

Volumn 91, Issue 3, 1996, Pages 165-169

  Rikans, Lora E ^a   Lopez, Tony R ^a   Hornbrook, Roger K ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Age and gender difference; Ascorbic acid; Dehydroascorbic acid reductase; Rat liver

Indexed keywords

ASCORBIC ACID; DEHYDROASCORBIC ACID REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; LIVER LEVEL; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

AGING; ANIMALS; ASCORBIC ACID; FEMALE; LIVER; MALE; NADH, NADPH OXIDOREDUCTASES; RATS; RATS, INBRED F344; SEX CHARACTERISTICS;

ANIMALIA;

EID: 0030582550     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01784-8     Document Type: Article

References (12)

1. [1] H. Padh, Cellular functions of ascorbic acid. Biochem. Cell Biol., 68 (1990) 1166-1173.
2. [2] H. Sies, Biochemistry of oxidative stress. Angew. Chem. Int. Ed. Engl., 25 (1986) 1058-1071.
3. [3] L.J. Machlin and A. Bendich, Free radical tissue damage: protective role of antioxidant nutrients. FASEB J., 1 (1987) 441-445.
4. [4] A. Meister, On the antioxidant effects of ascorbic acid and glutathione. Biochem. Pharmacol., 44 (1992) 1905-1915.
5. [5] W.W. Wells and D.P. Xu, Dehydroascorbate reduction. J. Bioenerg. Biomembr., 26 (1994) 369-377.
6. [6] E. Maellaro, B. Del Bello, L. Sugherini, A. Santucci, M. Comporti and A.F. Casini, Purification and characterization of glutathione-dependent dehydroascorbate reductase from rat liver. Biochem. J., 301 (1994) 471-476.
7. [7] B. Del Bello, E. Maellaro, L. Sugherini, A. Santucci, M. Comporti and A.F. Casini, Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3α-hydroxysteroid dehydrogenase. Biochem. J., 304 (1994) 385-390.
8. [8] L.E. Rikans and D.R. Moore, Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats. Biochim. Biophys. Acta. 966 (1988) 269-275.
9. [9] L.E. Rikans and Y. Cai, Age-associated enhancement of diquat-induced lipid peroxidation and cytotoxicity in isolated rat hepatocytes. J. Pharmacol. Exp. Ther., 262 (1992) 271-278.
10. [10] V.G. Zannoni, M. Lynch, S. Goldstein and P. Sato, A rapid micromethod for the determination of ascorbic acid in plasma and tissues. Biochem. Med. 11 (1974) 41-48.
11. [11] R.L. Stahl, L.F. Liebes and R. Silber, A reappraisal of leukocyte dehydroascorbate reductase. Biochim. Biophys. Acta, 839 (1985) 119-121.
12. [12] M.A.K. Markwell, S.M. Haas, L.L. Bieber and N.E. Tolbert, A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem., 87 (1978) 206-210.