Enhanced cell permeability increases the sensitivity of a yeast test for mutagens

Mutation Research - Genetic Toxicology

Volumn 370, Issue 2, 1996, Pages 81-89

  Staleva, L ^a   Waltscheva, L ^a   Golovinsky, E ^a   Venkov, P ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Bulgaria)

Author keywords

D7 mutagenicity test; Increased permeability; Saccharomyces cerevisiae

Indexed keywords

BENZO[A]PYRENE; HYDROXYUREA; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER;

ARTICLE; CELL MEMBRANE PERMEABILITY; MUTAGEN TESTING; MUTATION; PRIORITY JOURNAL; TECHNIQUE; WATER ANALYSIS; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 0030582414     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1218(96)00035-3     Document Type: Article

References (25)

1. Ames, B.N., J. McCann and E. Yamasaki (1975) Methods for detecting carcinogens and mutagens with Salmonella/mammalian-microsome mutagenity test, Mutation Res., 31, 347-364.
2. Fabre F. (1978) Induced intragenic recombination in yeast can occur during the G1 mitotic phase, Nature 272, 795-798.
3. Fahrig, R. (1975) Development of host mediated mutagenicity tests - yeast systems. Recovery of yeast cells out of testes, liver, lung and peritoneum of rats, Mutation Res., 31, 381-394.
4. Fahrig R. (1979) Evidence that induction and supression of mutations and recombination by chemical mutagens in S. cerevisiae during mitosis are jointly correlated, Mol. Gen. Genet., 168, 125-139.
5. Fink, G.R. and R. Lownstain (1969) Simplified method for testing mutagens in S. cerevisiae, J. Bacteriol., 100, 1126-1127.
6. Ivanov, V. and E. Golovinsky (1992) Investigations of genotoxic effect in water bazins in Burgas region, Proceedings of ECO Forum Burgas, pp. 41-44.
7. Kozhina, T., L., Stateva and P. Venkov (1979) Genetic anlysis of an osmotic sensitive Saccharomyces cerevisiae mutant VY1160, Mol. Gen. Genet., 170, 351-354.
8. Markisch, U., G. Reuter, L. Stateva and P. Venkov (1983) Mannan structure analysis of the fragile S. cerevisiae mutant VY1160, Int. J. Biochem., 15, 1373-1377.
9. Mayer, V.W., C.J. Goin and F.K. Zimmermann (1986) Aneuploidy and other genetic effects induced by hydroxyurea in S. cerevisiae, Mutation Res., 160, 19-26.
10. Morita, T. and Y. Yanagihara (1985) Osmotic-sensitive mutants of S. cerevisiae as screening organisms for promutagens and procarcinogens, Chem. Pharm. Bull., 33, 1576-1586.
11. Morita, T., Y. Iwamoto, T. Shimizu, T. Masuzawa and Y. Yanagihara (1989) Mutagenicity tests with a permeable mutant of yeast on carcinogens showing false-negative Salmonella assay, Chem. Pharm. Bull., 37, 407-409.
12. Moustacchi, E. (1980) Mutagenicity testing with eukaryotic microorganisms, Arch. Toxicol., 46, 99-110.
13. Neuhard, J. (1983) Utilization of preformed pyrimidine bases and nucleosides in: A. Munch-Petersen (Ed.), Metabolism of Nucleotides, Nucleosides and Nucleobases in Microorganisms, Academic Press, London, pp. 95-148.
14. De Nobel, J.G. and J.A. Barnett (1991) Passage of molecules through yeast cell wall: a brief assay-review, Yeast, 7, 313-323.
15. 6-hydroxyadenine studied by yeast oligonucleotide transformation assay, Mutation Res., 308, 43-51.
16. Parry, J.M. (1985) In: J. Ashby, F.J. de Serres, M. Draper, M. Ishidate, Jr., B.H. Margolin, B.E. Maher and M.D. Shelby (Eds.), Progress in Mutation Research, Vol. 5, Evaluation of Short-Term Tests for Carcinogens, Elsevier Science, Amsterdam, Oxford, New York, pp. 25-46.
17. Staleva, L. (1992) Construction of S. cerevisiae D7ts1 strain for studying mutagenic and carcinogenic action, Compt. Ren. Bulg. Acad. Sci., 47, 105-108.
18. Venkov, P. and V. Ivanov (1982) Uptake of DNA by fragile mutants of S. cerevisiae, Curr. Genet., 5, 153-155.
19. Venkov, P. and K.H. Scheit (1984) Effect of seminalplasmin or rRNA synthesis in S. cerevisiae, FEBS Lett., 172, 21-24.
20. Venkov, P., G. Milchev and A. Hadjiolov (1975) Rifampicin susceptability of ribonucleic acid synthesis in a fragile S. cerevisiae mutant, Antimicrob. Agents Chemother., 8, 627-632.
21. Venkov, P., L. Stateva and A. Hadjiolov (1977) Toyocamycin inhibition of ribosomal ribonucleic acid processing in an osmotic sensitive adenosine utilizing S. cerevisiae mutant, Biochem. Biophys. Acta, 474, 245-253.
22. Waltschewa, L., P. Venkov, B. Stoyanova and A. Hadjiolov (1976) Degradation of ribosomal precursor and polyadenilic acid-containing ribonucleic acids in S. cerevisiae caused by actinomycin D, Arch. Biochem. Biophys., 176, 630-637.
23. Zimmermann, F.K. (1992) Tests for recombinogens in fungi, Mutation Res., 284, 147-158.
24. Zimmermann, F. K., R. Kern and H. Rasenberger (1975) A yeast strain for simultaneous detection of induced mitotic crossingover, mitotic gene conversion and reverse mutation, Mutation Res., 28, 381-388.
25. Zlotnick, H., M.P. Fernandez, B. Bowers and E. Cabib (1984) S. cerevisiae mannoproteins form an external cell wall layer that determines wall porosity, J. Bacteriol., 159, 1018-1026.