Cardiac electrophysiological effects of falipamil in the conscious dog: Comparison with alinidine

European Journal of Pharmacology

Volumn 306, Issue 1-3, 1996, Pages 93-98

  Boucher, Michel ^a,b   Chassaing, Claude ^a   Chapuy, Eric ^a  

^a INSERM   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

alindine; atrial myocardium; AV node; AV blocked dog; blood pressure; conscious intact dog; falipamil; His bundle; sinoatrial node

Indexed keywords

ALINIDINE; BRADYCARDIC AGENT; FALIPAMIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ATRIOVENTRICULAR BLOCK; BLOOD PRESSURE; CONSCIOUSNESS; CONTROLLED STUDY; DOG; FEMALE; HEART ATRIUM; HEART ELECTROPHYSIOLOGY; HEART MUSCLE REFRACTORY PERIOD; HEART RATE; HEART VENTRICLE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; SINUS NODE RECOVERY TIME; SINUS RHYTHM; WENCKEBACH PERIOD;

EID: 0030582073     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00178-1     Document Type: Article

References (31)

1. f) in guinea-pig dissociated sinoatrial node cells, Br. J. Pharmacol. 110, 343.
2. Boucher, M. and P. Duchêne-Marullaz, 1985, Methods for producing experimental complete atrioventricular block in dogs, J. Pharmacol. Methods 13, 95.
3. Boucher, M., P. Duchêne-Marullaz and J. Lavarenne, 1979, Catecholamines and cardiac rhythms in the unanesthetized dog with chronic AV block, Am. J. Physiol. 237, H10.
4. Boucher, M., C. Dubray and P. Duchêne-Marullaz, 1986, Differing effects of spontaneous and atropine-induced variations of vagal tone on atrial refractoriness in the conscious dog, Meth. Find. Exp. Clin. Pharmacol. 8, 397.
5. Boucher, M., E. Chapuy, M.A. Lefebvre, A. Mignot and P. Duchêne-Marullaz, 1989, Mechanisms of chronotropic cardiac effects of alinidine and plasma concentration-response relationships in the conscious dog with chronic atrioventricular block, Naunyn-Schmied. Arch. Pharmacol. 339, 630.
6. Boucher, M., C. Dubray, J.H. Li, M. Paire and P. Duchêne-Marullaz, 1991, Influence of pentobarbital and chloralose anesthesia on quinidine-induced effects on atrial refractoriness and heart rate in the dog, J. Cardiovasc. Pharmacol. 17, 199.
7. Boucher, M., C. Chassaing, E. Chapuy and P. Duchêne-Marullaz, 1994, Chronotropic cardiac effects of falipamil in conscious dogs: interactions with the autonomic nervous system and various ionic conductances, J. Cardiovasc. Pharmacol. 23, 569.
8. Boucher, M., C. Chassaing and E. Chapuy, 1995, Cardiac electrophysiologic effects of alinidine, a specific bradycardic agent, in the conscious dog: plasma concentration-response relations, J. Cardiovasc. Pharmacol. 25, 229.
9. Brunner, F. and W.R. Kukovetz, 1988, Binding of two specific bradycardic agents, alinidine and AQ-A39, to muscarinic receptors of guinea-pig atria and ventricle, J. Cardiovasc. Pharmacol. 11, 222.
10. Chassaing, C., D. Godenèche, M. Boucher and P. Duchêne-Marullaz, 1979, A comparison of changes in atropine-induced tachycardia and atropine concentration in conscious dogs, Eur. J. Pharmacol. 58, 433.
11. Dämmgen, J., R. Kadatz and W. Diederen, 1981, Cardiovascular actions of 5,6-dimelhoxy-2-{3-[(alpha-(3,4-dimethoxy) phenylethyl)-methylamino]propyl}phthalimidine (AQ-A39), a specific bradycardic agent, Arzneim.-Forsch. 31, 666.
12. Dubray, C., M. Boucher, M. Paire and P. Duchêne-Marullaz, 1983, A method for determining the atrial effective refractory period in the unanesthetized dog, J. Pharmacol. Methods 9, 157.
13. Duchêne-Marullaz P., R. Fabry-Delaigue, G. Gueorguiev and J.P. Kantelip, 1982, Influence of chloralose and pentobarbitone sodium on atrioventricular conduction in dogs, Br. J. Pharmacol. 77, 309.
14. Greisheimer, E.M., 1965, The circulatory effects of anesthetics, in: Handbook of Physiology, Circulation, Sect. 2, Vol. III (American Physiological Society, Washington, DC) p. 2477.
15. Hohnloser, S., J. Weirich, H. Homburger and H. Antoni, 1982, Electrophysiological studies on effects of AQ-A39 in the isolated guinea-pig heart and myocardial preparations, Arzneim.-Forsch. 32, 730.
16. Kantelip, J.P., J.M. Talmant and P. Duchêne-Marullaz, 1988, Effects of diproteverine, a new calcium antagonist on sinoatrial node and atrioventricular conduction in conscious unsedated dogs, J. Cardiovasc. Pharmacol. 12, 432.
17. Kawada, M., K. Satoh and N. Taira, 1984, Analyses of the cardiac action of the bradycardic agent, AQ-A39, by use of isolated, blood-perfused dog-heart preparations, J. Pharmacol. Exp. Ther. 228, 484.
18. Kobinger, W. and C. Lillie, 1981, AQ-A39 (5,6-dimethoxy-2-{3-[(alpha-(3,4-dimethoxy)-phenylethyl)-methylamino]propyl}-phthalimidine), a specific bradycardic agent with direct action on the heart, Eur. J. Pharmacol. 72, 153.
19. Li, J.H., M. Boucher and P. Duchêne-Marullaz, 1986, Chronotropic cardiac effects of histamine in the conscious dog with chronic atrioventricular block: interactions with the autonomic nervous system, Agents Actions 19, 150.
20. ++ and NaCl solutions, Eur. J. Pharmacol. 87, 25.
21. Lindmar, R., K. Löffelholz and W. Weide, 1979, Inhibition by pentobarbital of the acetylcholine release from the postganglionic parasympathetic neuron of the heart, J. Pharmacol. Exp. Ther. 210, 166.
22. Mandel, W.J., H. Hakayama, R. Danzig and H.S. Marcus, 1971, Evaluation of sino-atrial node function in man by overdrive suppression, Circulation 44, 59.
23. Olmsted, F. and I.H. Page, 1966, Hemodynamic changes in dogs caused by sodium pentobarbital anesthesia, Am. J. Physiol. 210, 817.
24. Osterrieder, W., D. Pelzer, Q.F. Yang and W. Trautwein, 1981, The electrophysiological basis of the bradycardic action of AQ-A39 on the sinoatrial node, Naunyn-Schmied. Arch. Pharmacol. 317, 233.
25. Pelzer, D., W. Trautwein and T.F. McDonald, 1982, Calcium channel block and recovery from block in mammalian ventricular muscle treated with organic channel inhibitors, Pflügers Arch. 394, 97.
26. Rigel, D.F., D. Lipson and P.G. Katona, 1984, Excess tachycardia: heart rate after antimuscarinic agents in conscious dogs, Am. J. Physiol. 246, H168.
27. Robinson, J.L., W.C. Farr and G. Grupp, 1973, Atrial rate response to ventricular pacing in the unanesthetized A-V blocked dog, Am. J. Physiol. 224, 40.
28. Takeda, M., Y. Furukawa, Y. Ogiwara, K. Saegusa, M. Haniuda, K. Akahane and S. Chiba, 1989, Effects on atrio-ventricular conduction of alinidine and falipamil injected into the AV node artery of the anesthetized dog, Arch. Int. Pharmacodyn. Ther. 297, 39.
29. Trautwein, W., D. Pelzer, T.F. McDonald and W. Osterrieder, 1981, AQ-A39, a new bradycardic agent which blocks myocardial calcium (Ca) channels in a frequency-and voltage-dependent manner, Naunyn-Schmied. Arch. Pharmacol. 317, 228.
30. Trautwein, W., D. Pelzer and T.F. McDonald, 1983, Interval-and voltage-dependent effects of the calcium channel-blocking agents D600 and AQ-A39 on mammalian ventricular muscle, Circ. Res. 52 (Suppl. 1), 60.
31. Van Bogaert, P.P. and M. Goethals, 1987, Pharmacological influence of specific bradycardic agents on the pacemaker current of sheep cardiac Purkinje fibres. A comparison between three different molecules, Eur. Heart J. 8 (Suppl. L), 35.