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20
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85030199336
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note
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8. Typical experimental procedure: The xanthate (1 mmole) is dissolved in refluxing 2-propanol under an inert atmosphere. Di-lauroyl peroxide (0.8-1.3 mmoles) is added in 5% portions every hour or so until consumption of the starting material. When mixtures of solvents are used such as 2-propanol / diisopropyl ether (1:1) or 2-propanol / 1,2-dichloroethane (1:1), the boiling point is a little lower so that larger portions (15-20%) of the peroxide can be added every about 4 hours (the process can of course be interrupted at any time for convenience then continued again the next day). Upon completion, the solvent is evaporated under reduced pressure and the residue purified by chromatography in the usual way (for large scale work it is advisable to destroy any residual peroxide before concentration).
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(c) Hartwig, W. Tetrahedron 1983, 39, 2609-2645.
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Hartwig, W.1
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