In situ nick end-labeling detects necrosis of hippocampal pyramidal cells induced by kainic acid

Neuroscience Letters

Volumn 212, Issue 2, 1996, Pages 139-142

  Nishiyama, Kazutoshi ^a   Kwak, Shin ^a   Takekoshi, Susumu ^b   Watanabe, Keiichi ^b   Kanazawa, Ichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Electron microscopy; Gel electrophoresis; Glutamate receptor; In situ nick end labeling; Kainate; Neurotoxicity; TUNEL

Indexed keywords

GLUTAMATE RECEPTOR; KAINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

EID: 0030581105     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12794-4     Document Type: Article

References (15)

1. [1] Ansari, B., Coates, P.J., Greenstein, B.D. and Hall, P.A., In situ end-labeling detects DNA strand breaks in apoptosis and other physiological and pathological states, J. Pathol., 170 (1993) 1-8.
2. [2] Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A., Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J. Cell Biol., 119 (1992) 493-501.
3. [3] Kerr, J.F.R., Wyllie, A.W. and Currie, A.R., Apoptosis: basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer, 26 (1972) 239-257.
4. [4] Kerr, J.F.R., Searle, J., Harmon, B.V. and Bishop, C.J., Apoptosis. In C.S. Potten (Ed.), Perspectives on Mammalian Cell Death, Oxford University Press, Oxford, 1987, pp. 93-128.
5. [5] Nadler, J.V., Perry, B.W. and Cotman, C.W., Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells, Nature, 271 (1978) 676-677.
6. [6] Nadler, J.V., Perry, B.W. and Cotman, C.W., Preferential vulnerability of hippocampus to intraventricular kainic acid. In E.G. McGeer, J.M. Olney and P.L. McGeer (Eds.), Kainic Acid as a Tool in Neurobiology, Raven Press, New York, 1978, pp. 219-237.
7. [7] Nadler, J.V., Perry, B.W. and Cotman C.W., Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid, Brain Res., 182 (1980) 1-9.
8. [8] Nadler, J.V., Perry, B.W., Gentry, C. and Cotman C.W., Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid, J. Comp. Neurol., 192 (1980) 333-359.
9. [9] Nitatori, T., Sato, N., Waguri, S., Karasawa, Y., Araki, H., Shibanai, K., Kominami, E. and Uchiyama, Y., Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis, J. Neurosci., 15 (1995) 1001-1011.
10. [10] Pollard, H., Charriaut-Marlangue, C., Cantagrel, S., Represa, A., Robain, O., Moreau, J. and Ben-Ari, Y., Kainate-induced apoptotic cell death in hippocampal neurons, Neuroscience, 93 (1994) 7-18.
11. [11] Sloviter, R.S., Valiquette, G., Abrams, G.M., Ronk, E., Sollas, A., Paul, L.A. and Neubort, S., Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy, Science, 243 (1989) 535-538.
12. [12] Stanisic, T., Sadlowski, R., Lee, C. and Grayhack, J.T., Partial inhibition of castration induced ventral prostate regression with actinomycin D and cycloheximide, Invest. Urol., 16 (1978) 19-25.
13. [13] Wijsman, J.H., Jonker, R.R., Keijzer, R., Van de Velde, C.J.H., Cornelisse, C.J. and Van Dierendonck, J.H., A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmentation DNA, J. Histochem. Cytochem., 41 (1993) 7-12.
14. [14] Wood, K.A., Dipasquale, B. and Youle, R.J., In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanism of cell loss in developing cerebellum, Neuron, 11 (1993) 621-632.
15. [15] Wyllie, A.H., Morris, R.G., Smith, A.L. and Dunlop, D., Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis, J. Pathol., 142 (1984) 67-77.