Serial passage of human immunodeficiency virus type 1, generates misalignment deletions in non-essential accessory genes

Virus Research

Volumn 46, Issue 1-2, 1996, Pages 139-147

  Nakaya, Takaaki ^a   Fujinaga, Koh ^a   Doi, Hirofumi ^b   Suzuki, Satoko ^a   Takahashi, Hirokazu ^a   Nishino, Yoshii ^a,d   Kishi, Masahiko ^a   Azuma, Ichiro ^a   Luftig, Ronald B ^c   Ikuta, Kazuyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b FUJITSU LABORATORIES LTD   (Japan)

^c LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^d AZABU UNIVERSITY   (Japan)

Author keywords

cytopathogenicity; deletion; human immunodeficiency virus; vif; vpr

Indexed keywords

VIF PROTEIN; VPR PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DELETION MUTANT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; DNA, VIRAL; GENE DELETION; GENES, VIF; GENES, VPR; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; REPETITIVE SEQUENCES, NUCLEIC ACID; SERIAL PASSAGE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030580566     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(96)01396-2     Document Type: Article

References (37)

1. Adachi, A., Gendelman, H.E., Koenig, S., Folks, T., Willey, R., Rabson, A. and Martin, M.A. (1986) Production of acquired immunodeficiency syndrome-associated retro virus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59, 284-291.
2. Adachi, A., Ono, N., Sakai, H., Ogawa, K., Shibata, R., Kiyomasu, T., Masuike, H. and Ueda, S. (1991) Generation and characterization of the human immunodeficiency virus type 1 mutants. Arch. Virol. 117, 45-58.
3. Armed, R., Chakraborty, P. and Fields, B.N. (1980) Genetic variation during lytic reovirus infection: High-passage stocks of wild-type reovirus contain temperature-sensitive mutants. J. Virol. 34, 285-287.
4. Coffin, J.M. (1990) Retroviridae and their replication. In: B.N. Fields, D.M. Knipe, R.M. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath and B. Roizman (Eds.), Virology, 2nd edn., Vol. 1, Raven Press, New York, pp. 1473-1500.
5. Coffin, J.M., Tsichlis, P.N., Barker, C.S., Voynow, S. and Robinson, H. (1980) Variation in avian retrovirus genomes. Ann. N.Y. Acad. Sci. 354, 410-425.
6. Fisher, A.G., Ensoli, B., Ivanoff, L., Chamberlain, M., Petteway, S., Ratner, L., Gallo, R.C. and Wong-Staal, F. (1987) The sor gene of HIV-1 is required for efficient virus transmission in vitro. Science 237, 888-893.
7. Heinzinger, N.K., Bukrinsky, M.I., Haggerty, S.A., Ragland, A.M., Kewalramani, V., Lee, M.-A., Gendelman, H.E., Ratner, L., Stevenson, M. and Emerman, M. (1994) The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc. Natl. Acad. Sci. 91, 7311-7315.
8. Huang, A.S. and Baltimore, D. (1970) Defective viral particles and viral disease processes. Nature 226, 325-327.
9. Jones, J.S., Allan, R.W. and Temin, H.M. (1994) One retroviral RNA is sufficient for synthesis of viral DNA. J. Virol. 68, 207-216.
10. Kestler, H.W. III, Ringer, D.J., Mori, K., Panicali, D.L., Shgal, P.L., Daniel M.D. and Desrosiers, R.C. (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662.
11. Kirchhoff, F., Kestler III, H.W. and Desrosiers, R.C. (1994) Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene. J. Virol. 68, 2031-2037.
12. Kishi, M., Nishino, Y., Sumiya, M., Ohki, K., Kimura, T., Goto, T., Nakai, M., Kakinuma, M. and Ikuta, K. (1992) Cells surviving infection by human immunodeficiency virus type 1 (HIV-1): vif or vpu mutants produce non-infectious or markedly less cytopathic viruses. J. Gen. Virol. 73, 77-87.
13. Kishi, M., Tokunaga, K., Zheng, Y.-H., Bahmani, M.K., Kakinuma, M., Nonoyama, M., Lai, P.K. and Ikuta, K. (1995a) Superinfection of a defective human immunodeficiency virus type-1 provirus-carrying T-cell clone with vif or vpu mutants gives cytopathic virus particles by homologous recombination. AIDS Res. Hum. Retrovirus 11, 45-53.
14. Kishi, M., Zheng, Y.-H., Bahmani, M.K., Tokunaga, K., Takahashi, H., Kakinuma, M., Lai, P.K., Nonoyama, M., Luftig, R.B. and Ikuta, K. (1995b) Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive. T-cells. J. Virol. 69, 7507-7518.
15. Meyerhans, A., Vartanian, J.P. and Wain-Hobson, S. (1990) DNA recombination during PCR. Nucleic Acids Res. 18, 1687-1691.
16. McCune, J.M. (1995) Viral latency in HIV disease. Cell 82, 183-188.
17. Nakaya, T., Fujinaga, K., Kishi, M., Oka, S., Kurata, T., Jones, I.M. and Ikuta, K. (1994) Nonsense mutations in the vpr gene of HIV-1 during in vitro virus passage and in HIV-1 carrier-derived peripheral blood mononuclear cells. FEBS Lett. 354, 17-22.
18. Nishino, Y., Kishi, M., Sumiya, M., Ogawa, K., Adachi, A., Maotani-Imai, K., Kato, S., Hirai, K. and Ikuta, K. (1991) Human immunodeficiency virus type 1 vif, vpr, and vpu mutants can produce persistently infected cells. Arch. Virol. 120, 181-192.
19. Nishino, Y., Nakaya, T., Fujinaga, K., Kishi, M., Azuma, I. and Ikuta, K. (1994) Persistent infection of MT-4 cells by human immunodeficiency virus type 1 becomes increasingly likely with in vitro serial passage of wild-type but not nef mutant virus. J. Gen. Virol. 75, 2241-2251.
20. Pathak, V.K. and Temin, H.M. (1990) Broad spectrum of in vivo forward mutations, hypermutations, and mutational hot spots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions. Proc. Natl. Acad. Sci. USA 87, 6024-6028.
21. Pulsinelli, G.A. and Temin, H.M. (1991) Characterization of large deletions occurring during a single round of retrovirus vector replication: novel deletion mutation mechanism involving errors in strand transfer. J. Virol. 65, 4786-4797.
22. Ricchetti, M. and Buc, H. (1990) Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent. EMBO J. 9, 1583-1593.
23. Rogel, M.E., Wu, L.I. and Emerman, M. (1995) The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J. Virol. 69, 882-888.
24. Spindler, K.R., Horodyski, F.M. and Holland, J.J. (1982) High multiplicities of infection favor rapid and random evolution of vesicular stomatitis virus. Virology 119, 98-108.
25. Strebel, K., Daugherty, D., Cohen, D., Folks, T. and Martin, MA. (1987) The HIV 'A' (sor) gene product is essential for virus infectivity. Nature 38, 728-730.
26. Strebel, K., Klimkait, T. and Martin, M.A. (1988) A novel gene of HIV-1, vpu, and its 16-kilodalton product. Science 241, 1221-1223.
27. Swanstrom, R., Parker, R.C., Varmus, H.E. and Bishop, J.M. (1983) Transduction of a cellular oncogene: The genesis of Rous sarcoma virus. Proc. Natl. Acad. Sci. USA 80, 2519-2523.
28. Temin, H.M. (1989) Evolution of retroviruses. In: A. Notkins and M.B.A. Oldstone (Eds.), Concepts in Viral Pathogenesis, Vol. 3, Springer-Verlag, New York, pp. 189-196.
29. Terwilliger, E.F. (1992) The accessory gene functions of the primate immunity viruses. In: W.C. Koff, F. Wong-Staal and R.C. Kennedy (Eds.), AIDS Research Reviews, Vol. 2, Marcel Dekker, New York, pp. 3-27.
30. Terwilliger, E.F., Cohen, E.A., Lu, Y., Sodrosky, J.G. and Haseltine, W.A. (1989) Functional role of human immunodeficiency virus type 1 vpu. Proc. Natl. Acad. Sci. USA 86, 5163-5167.
31. Varmus, H. and Brown, P. (1989) Retroviruses. In: D.E. Berg and M.M. Howe (Eds.), Mobile DNA, American Society for Microbiology, Washington, D.C., pp. 53-108.
32. Vartanian, J.-P., Meyerhans, A., Asjo, B. and Wain-Hobson, S. (1991) Selection, recombination, and G-A hypermutation of human immunodeficiency virus type 1 genomes. J. Virol. 65, 1779-1788.
33. von Schwedler, U., Kornbluth, R.S. and Trono, D. (1994) The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. Proc. Natl. Acad. Sci. USA 91, 6992-6996.
34. Voynow, S.L. and Coffin, J.M. (1985) Evolutionary variants of Rous sarcoma virus: Large deletion mutants do not result from homologous recombination. J. Virol. 55, 67-78.
35. Walter, N.G. and Strunk, G. (1994) Strand displacement amplification as an in vitro model for rolling-circle replication: Deletion formation and evolution during serial transfer. Proc. Natl. Acad. Sci. USA 91, 7937-7941.
36. Youngner, J.S., Jones, E.V., Kelley, M. and Frielle, D.W. (1981) Generation and amplification of temperature-sensitive mutants during serial undiluted passages of vesicular stomatitis virus. Virology 108, 87-97.
37. Yunoki, M., Maotani-Imai, K., Kusuda, H., Motoyama, M., Miyake, S., Imai, H., Shin, Y.S., Kato, S., Sano, K., Morita, C., Nakai, M., Hirai, K. and Ikuta, K. (1991) Production of infectious particles from defective human immunodeficiency virus type 1 (HIV-1)-producing cell clones by superinfection with infectious HIV-1. Arch. Virol. 116, 143-158.