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4. In order to describe as a group all of the epoxides discussed in this review, the term achiral is used in preference to the term meso. For example, cyclopentene oxide could not strictly be described as meso since, unlike cis-cyclooctene oxide for example, cyclopentene oxide does not belong to a set of diastereomers that also includes at least one chiral member. For a full discussion see: Eliel, E. L.; Wilen, S. H.; Mander, L. N. Stereochemistry of Organic Compounds; Wiley: New York, 1994.
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13. The amine precursor to 7 is commercially available (Aldrich Chemical Co, Oxford Asymmetry Ltd).
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17
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85136549459
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3) for > 99% ee of (R)-cyclohex-2-enol (note 3 in ref. 32 below, see also refs. 24a and 19b).
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