Detection and quantification of the hypnotic zopiclone, connected with an uncommon case of drowning

Forensic Science International

Volumn 83, Issue 1, 1996, Pages 67-72

  Mannaert, Erik ^a   Tytgat, Jan ^a   Daenens, Paul ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cyclopyrrolones; Drowning; Radioimmunoassay; Zopiclone

Indexed keywords

DIAZEPAM; ZOPICLONE;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; DROWNING; DRUG DETERMINATION; DRUG OVERDOSE; DRUG TISSUE LEVEL; FATALITY; FORENSIC MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SUICIDE; TESTIS;

EID: 0030580407     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/0379-0738(96)02018-X     Document Type: Article

References (12)

1. [1] B. Musch and F. Maillard, Zopiclone, the third generation hypnotic: a clinical overview. Int. Clin. Psychopharmacol, 5 (1990) 147-158.
2. [2] J. Gaillot, D. Heusse, G.W. Hougton, J.M. Aurele and J.F. Dreyfus, Pharmacokinetics and metabolism of zopiclone. Pharmacology, 27 (Suppl. 2) (1983) 76-91.
3. [3] K.L. Goa and R.C. Heel, Zopiclone, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as a hypnotic. Drugs, 32 (1986) 48-65.
4. [4] K. Aranko, M. Henriksson, C, Hublin and A.M. Seppäläinen, Misuse of zopiclone and convulsions during withdrawal. Pharmacopsychiatry, 24 (1991) 138-140.
5. [5] J. Thakore and T.G. Dinan, Physical dependence following zopiclone usage: a case report. Hum. Psychopharmacol., 7 (1992) 143-145.
6. [6] D.J. Pounder and J.I. Davies, Zopiclone poisoning: tissue distribution and potential for postmortem diffusion. Forensic Sci. Int., 65 (1994) 177-183.
7. [7] E. Mannaert and P. Daenens, Development of a radioimmunoassay for the determination of N-demethylzopiclone in urine. Analyst, 119 (1994) 2221-2226.
8. [8] E. Mannaert and P. Daenens, Development of a fluorescence polarization immunoassay for the routine detection of N-demethylzopiclone in urine samples. Analyst, 121 (1996) 857-861.
9. 125I]-iodophenyl) propionamide}, a prosthetic derivative of zopiclone for use in immunoassay. J. Radiolabelled Comp. Radiopharm., 34 (1994) 281-287.
10. [10] P.J. Boniface, I.C. Martin, S.L. Nolan and S.T. Tan, Development of a method for the determination of zopiclone in whole blood. J, Chromatogr., 584 (1992) 199-206.
11. [11] C. Cotrel, C. Jeanmart and M.N. Messer, United States Patent 3,862,149 (1975).
12. [12] C. Stanley, P. Mitchell and C.M. Kaye, Simple and sensitive method for monitoring zopiclone in plasma by HPLC with fluorescence detection. Analyst, 110 (1985) 83-84.