Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis

European Journal of Pharmacology

Volumn 313, Issue 1-2, 1996, Pages

  Montuschi, Paolo ^a   Currò, Diego ^a   Ciabattoni, Giovanni ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Anaphylaxis, lung; Eicosanoid; Tachykinin receptor antagonist

Indexed keywords

ICOSANOID; MEN 10627; NEUROKININ 2 RECEPTOR; NEUROKININ A [4-10][5 TYROSINE 6,8,9 DEXTRO TRYPTOPHAN 10 LYSINE]; PROSTAGLANDIN E2; TACHYKININ RECEPTOR ANTAGONIST; THROMBOXANE B2; CYCLOPEPTIDE; DRUG DERIVATIVE; NEUROKININ A; NEUROKININ A(4 10), TYR(5) TRP(6,8,9) LYS(10); NEUROKININ A(4-10), TYR(5)-TRP(6,8,9)-LYS(10)-; PEPTIDE FRAGMENT; TACHYKININ RECEPTOR;

ANAPHYLAXIS; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; GUINEA PIG; IN VITRO STUDY; LUNG; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SMOOTH MUSCLE;

ANAPHYLAXIS; ANIMALS; BRONCHOCONSTRICTION; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; LUNG; MUSCLE, SMOOTH; NEUROKININ A; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; RECEPTORS, TACHYKININ; THROMBOXANE B2;

EID: 0030578979     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00545-6     Document Type: Article

References (8)

1. Bertrand, C., P. Geppetti, P.D. Graf, A. Foresi and J.A. Nadel, 1993, Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea-pigs, Am. J. Physiol. 265, L507.
2. Ciabattoni, G. and P. Preziosi, 1985, Isolated and ventilated guinea-pig lung: a method for studying drug interaction with cyclooxygenase and lipoxygenase pathways, Br. J. Pharmacol. 86, 649P.
3. Ciabattoni, G., P. Montuschi, D. Currò, G. Togna and P. Preziosi, 1993, Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung, Br. J. Pharmacol. 109, 243.
4. Lilly, C.M., A.E. Hall, I.W. Rodger, L. Kobzik, K.J. Haley and J.M. Drazen, 1995, Substance P-induced histamine release in tracheally perfused guinea pig lungs, J. Appl. Physiol. 78, 1234.
5. Lundberg, J.M. and A. Saria, 1987, Polypeptide containing neurons in airway smooth muscle, Ann. Rev. Physiol. 49, 557.
6. Maggi, C.A., S. Giuliani, L. Ballati, A. Lecci, S. Manzini, R. Patacchini, A.R. Renzetti, P. Rovero and A, Giachetti, 1991, In vivo evidence for tachykinin transmission using a new NK-2 receptor-selective antagonist, MEN 10,376, J. Pharmacol. Exp, Ther. 257, 1172.
7. Preziosi, P. and G. Ciabattoni, 1986, Perfused and ventilated guinea-pig lung: a method for evaluating xenobiotic effects on arachidonic acid using formaldehyde, Arch. Toxicol. S9, 436.
8. Ricciardolo, F.L.M., J.A. Nadel, P.D. Graf, C. Bertrand, S. Yoshihara and P. Geppetti, 1994, Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs, Br. J. Pharmacol. 113, 508.