H-ras transfection of the rat kidney cell line NRK-52E results in increased induction of c-fos, c-jun and hsp70 following sulofenur treatment

Cancer Letters

Volumn 106, Issue 2, 1996, Pages 199-205

  Gu, H ^a   Smith, M W ^a   Phelps, P C ^a   Berezesky, I K ^a   Merriman, R L ^b   Boder, G B ^c   Trump, B F ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

c fos; c jun; Cytosolic Ca2+; H ras; hsp 70; Kidney cells; Protein kinases; Sulofenur

Indexed keywords

CALCIUM ION; CALPHOSTIN C; EGTAZIC ACID; HEAT SHOCK PROTEIN 70; PROTEIN KINASE C; STAUROSPORINE; SULOFENUR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; KIDNEY CELL; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; ONCOGENE H RAS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030578919     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04314-5     Document Type: Article

References (21)

1. Houghton, P.J., Houghton, J.A., Myers, I., Cheshire, P., Howbert, J.S. and Grindey, G.B. (1989) Evaluation of N-(5-indanylsulfonyl)-N′-4-chlorophenyl-urea against xenografts of pediatric rhabdomyosarcoma. Cancer Chemother. Pharmacol., 25, 84-87.
2. Grindey, G.B., Boder, G.B., Grossman, C.S., Howbert, J.J., Poore, G.A., Shaw, W.N., Todd, G.C. and Worzalla, J.F. (1987) Further development of diarylsulfonylureas as novel anticancer drugs. Proc. Am. Assoc. Cancer Res., 28, 309.
3. Thakar, J.H., Chapin, C., Berg, R.H., Ashmun, R.A. and Houghton, P.J. (1991) Effect of antitumor diarylsulfonylureas on in vivo and in vitro mitochondrial structure and functions. Cancer Res., 51, 6286-6291.
4. Rush, G.F., Rinzel, S., Boder, G., Heim, R.A., Toth, J.E. and Ponsler, G.D. (1992) Effects of diarylsulfonylurea antitumor agents on the function of mitochondria isolated from rat liver and GC3/c1 cells. Biochem. Pharmacol., 44, 2387-2394.
5. 2+ levels in isolated rat hepatocytes. Metabolism, 52, 624-630.
6. i) deregulation and cell death in parent and H-ras-transfected rat kidney cell lines, NRK-52E and H/1.2NRK-52E. Cancer Lett., 97, 7-15.
7. Phelps, P.C., Jain, P.T., Berezesky, I.K., Boder, C.B. and Trump, B.F. (1994) Sulofenur cytotoxicity and changes in cytosolic calcium and mitochondrial potential in human colon adenocarcinoma cell lines. Cancer Lett., 88, 27-35.
8. i in induction of c-fos, c-jun, and c-myc RNA in rat PTE after oxidative stress. FASEB J., 6, 919-924.
9. Karin, M. (1992) Signal transduction from cell surface to nucleus in development and disease. FASEB J.. 6, 2581-2590.
10. 2+ and the regulation of early response gene expression in HL-60 myeloid leukemia cells. J. Biol. Chem., 268, 16596-16601.
11. Berrige, M.J. (1993) Inositol trisphosphate and calcium signalling. Nature, 361, 315-325.
12. Morimoto, R.I. (1993) Cells in stress, transcriptional activation of heat shock genes. Science, 259, 1409-1410
13. 2+ and protein kinases in the induction of the hsp70 gene in rat proximal tubular epithelial cells. Kidney Int., 45, 1093-1103.
14. Angel, P. and Karin, M. (1991) The role of Jun, Fos and the AP-1 complex on cell-proliferation and transformation. Biochim. Biophys. Acta, 1072, 129-157.
15. Travis, J. (1993) Novel anticancer agents move closer to reality. Science, 263, 1877-1878.
16. Medema, R.H. and Bos, J.L. (1993) The role of p21ras in receptor tyrosine kinase signaling. Crit. Rev. Oncogenesis, 4, 615-661.
17. Chomczynski, P., and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenolchloroform extraction. Anal. Biochem., 162, 156-159.
18. Fornace, Jr., A.J. and Mitchell, J.B. (1986) Induction of B2 RNA polymerase III transcription by heat shock, enrichment for heat shock induced sequences in rodent cells by hybridization substation. Nucleic Acids Res., 14, 5793-5811.
19. Kobavashi, E., Nakano, H., Morimoto, M. and Tamaoki, T. (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun, 159, 548-553.
20. Nye, S.H., Squinto, S.P., Glass, D.J., Stitt, T.N., Hantzopoulos, P., Macchi, M.J., Lindsay, N.S., Ip, N.Y. and Yancopoulos, G.D. (1992) K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses. Mol. Biol. Cell, 3, 677-686.
21. Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M. and Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262, 5592-5595