Extracellular cAMP depletion triggers stalk gene expression in Dictyostelium: Disparities in developmental timing and dose dependency indicate that prespore induction and stalk repression by cAMP are mediated by separate signaling pathways

Developmental Biology

Volumn 177, Issue 1, 1996, Pages 152-159

  Soede, Ron D M ^a   Hopper, Neil A ^b   Williams, Jeffrey G ^b   Schaap, Pauline ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; DEFENSE MECHANISM; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SARCODINA; SPOROGENESIS;

EID: 0030578401     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1996.0152     Document Type: Article

References (31)

1. Berks, M., and Kay, R. R. (1988). Cyclic AMP is an inhibitor of stalk cell differentiation in Dictyostelium discoideum. Dev. Biol. 126, 108-114.
2. Berks, M., and Kay, R. R. (1990). Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum. Development 11, 977-984.
3. Brookman, J. J., Jermyn, K. A., and Kay, R. R. (1987). Nature and distribution of the morphogen DIP in the Dictyostelium slug. Development 100, 119-124.
4. Ceccarelli, A., Mahbubani, H., and Williams, J. G. (1991). Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in Dictyostelium. Cell 65, 983-989.
5. Datta, S., and Firtel, R. A. (1988). An 80-bp cis-acting regulatory region controls cAMP and developmental regulation of a prestalk gene in Dictyostelium. Genes Dev. 2, 294-304.
6. Dingermann, T., Reindl, N., Werner, H., Hildebrandt, M., Nellen, W., Harwood, A., Williams, J., and Nerke, K. (1989). Optimization and in situ detection of Escherichia coli β-galactosidase gene expression in Dictyostelium discoideum. Gene 85, 353-362.
7. Early, V. E., and Williams, J. G. (1988). A Dictyostelium prespore-specific gene is transcriptionally repressed by DIP in vitro. Development 103, 519-524.
8. Gross, J. D. (1994). Developmental decisions in Dictyostelium discoideum. Microb. Rev. 58, 330-351.
9. Harwood, A. J., Hopper, N. A., Simon, M.-N., Driscoll, D. M., Veron, M., and Williams, J. G. (1992). Culmination in Dictyostelium is regulated by the cAMP-dependent protein kinase. Cell 69, 615-624.
10. Harwood, A. J., Plyte, S. E., Woodgett, J., Strutt, H., and Kay, R. R. (1995). Glycogeen synthase kinase 3 regulates cell fate in Dictyostelium. Cell 80, 139-148.
11. Hopper, N. A., Harwood, A. J., Bouzid, S., Véron, M., and Williams, J. G. (1993a). Activation of the prespore and spore cell pathway of Dictyostelium differentiation by cAMP-dependent protein kinase and evidence for its upstream regulation by ammonia. EMBO J. 12, 2459-2466.
12. Hopper, N. A., Anjard, C., Reymond, C. D., and Williams, J. G. (1993b). Induction of terminal differentiation of Dictyostelium by cAMP-dependent protein kinase and opposing effects of intracellular and extracellular cAMP on stalk cell differentiation. Development 119, 147-154.
13. Johnson, R. L., Van Haastert, P. J. M., Kimmel, A. R., Saxe, C. L., III, Jastorff, B., and Devreotes, P. N. (1992). The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium. J. Biol. Chem. 267, 4600-4607.
14. Kay, R. R. (1989). Evidence that elevated intracellular cyclic AMP triggers spore maturation in Dictyostelium. Development 105, 753-759.
15. Mann, S. K. O., and Firtel, R. A. (1993). cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development. Development 119, 135-146.
16. Mann, S. K. O., Richardson, D. L., Lee, S., Kimmel, A. R., and Firtel, R. A. (1994). Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium. Proc. Natl. Acad. Sci. USA 91, 10561-10565.
17. Mehdy, M. C., and Firtel, R. A. (1985). A secreted factor and cyclic AMP jointly regulate cell-type-specific gene expression in Dictyostelium discoideum. Mol. Cell. Biol. 5, 705-713.
18. Newell, P. C. (1982). Cell surface binding of adenosine to Dictyostelium and inhibition of pulsatile signalling. FEMS Microbiol. Lett. 13, 417-421.
19. Newell, P. C., and Ross, F. M. (1982). Inhibition by adenosine of aggregation centre initiation and cyclic AMP binding in Dictyostelium. J. Gen. Microbiol. 128, 2715-2724.
20. Pears, C. J., and Williams, J. G. (1987). Identification of a DNA sequence element required for efficient expression of a developmentally regulated and cAMP-inducible gene of Dictyostelium discoideum. EMBO J. 6, 195-200.
21. Schaap, P., and Wang, W. (1986). Interactions between adenosine and oscillatory cAMP signaling regulate size and pattern in Dictyostelium. Cell 45, 137-144.
22. Simon, M.-N., Pelegrini, O., Veron, M., and Kay, R. R. (1992). Mutation of protein kinase A causes heterochronic development of Dictyostelium. Nature 356, 171-172.
23. So, J.-S., and Weeks, G. (1992). The effects of presumptive morphogens on prestalk and prespore cell gene expression in monolayers of Dictyostelium discoideum. Differentiation 51, 73-78.
24. Theibert, A., and Devreotes, P. (1984). Adenosine and its derivatives inhibit the cAMP signaling response in Dictyostelium discoideum. Dev. Biol. 106, 166-173.
25. Traynor, D., Kessin, R. H., and Williams, J. G. (1992). Chemotactic sorting to cAMP in the multicellular stage of Dictyostelium. Proc. Natl. Acad. Sci. USA 89, 8303-8307.
26. Wang, M., Van Haastert, P. J. M., and Schaap, P. (1986). Multiple effects of differential ion-inducing factor on prespore differentiation and cyclic-AMP signal transduction in Dictyostelium. Differentiation 33, 24-28.
27. Wang, M., Van Driel, R., and Schaap, P. (1988). Cyclic AMP-phosphodiesterase induces dedifferentiation of prespore cells in Dictyostelium discoideum slugs: Evidence that cyclic AMP is the morphogenetic signal for prespore differentiation. Development 103, 611-618.
28. Wang, M., and Schaap, P. (1989). Ammonia depletion and DIP trigger stalk cell differentiation in intact Dictyostelium discoideum slugs. Development 105, 569-574.
29. Weijer, C. J., and Durston, A. J. (1985). Influence of cAMP and hydrolysis products on cell type regulation in Dictyostelium discoideum. J. Embryol. Exp. Morphol. 86, 19-37.
30. Williams, J. G., Ceccarelli, A., McRobbie, S., Mahbubani, H., Kay, R. R., Early, A., Berks, M., and Jermyn, K. A. (1987). Direct induction of Dictyostelium prestalk gene expression by DIP provides evidence that DIP is a morphogen. Cell 49, 185-192.
31. Williams, J. G., Duffy, K. T., Lane, D. P., McRobbie, S. J., Harwood, A. J., Traynor, D., Kay, R. R., and Jermyn, K. A. (1989). Origins of the prestalk-prespore pattern in Dictyostelium development. Cell 59, 1157-1163.