Biological spin trapping methodology. III. Octanol-water partition coefficients of spin-trapping compounds

Journal of Biochemical and Biophysical Methods

Volumn 32, Issue 3, 1996, Pages 183-190

  Janzen, Edward G ^a,b   West, Melinda S ^a   Kotake, Yashige ^a   DuBose, Coit M ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL;

ARTICLE; CHEMISTRY; PRIORITY JOURNAL;

EID: 0030578395     PISSN: 0165022X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-022X(96)00008-5     Document Type: Article

References (15)

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3. 13C-NMR. Investigations in SDS micelles, DMPC vesicles and rat liver microsomes, J. Org. Chem., 54, 2915-2920.
4. [4] Hinton, R.D. and Janzen, E.G. (1992) Synthesis and characterization of phenyl-substituted C-phenyl-N-tert-butyl nitrones and some of their radical adducts. EPR parameters for hydroxyl and hydroperoxyl spin adducts, J. Org. Chem. 57, 2646-2651.
5. [5] Perkins, M.J. (1970) Essays on Free Radical Chemistry, Special Publication No. 24. p. 97, Chemical Society of London.
6. [6] Janzen, E.G., DuBose, C.M. and Kotake, Y. (1990) 2,4,6-Trimethoxyphenyl tert-butyl nitrone as a detector of hydroxyl radicals in the presence of peroxides, superoxide and peroxyl radicals, Tetra. Lett., 31, 7395-7398.
7. 13C, for enhanced radical addend recognition and spin adduct persistence, J. Am. Chem. Soc., 116. 3738-3743.
8. [8] Terabe, S., Kuruma, K. and Konaka, R. (1973) Spin Trapping by use of nitroso-compounds, VI. Nitrosodurene and other nitrosobenzene derivatives. J. Chem. Soc., Perkin Trans. 9, 1252-1258.
9. [9] Janzen, E.G., Wang, Y.Y. and Shetty, R.V. (1978) Spin trapping with α-pyridyl-N-oxide N-tert-butyl nitrones in aqueous solutions, A unique ESR spectrum for the hydroxyl radical adduct, J. Am. Chem. Soc., 100, 2923.
10. [10] Janzen, E.G., Zhang, Y.-K. and Arimura, M. (1995) Synthesis and spin-trapping chemistry of 5,5-dimethyl-2-(trifluoromethyl)-1-pyrroline N-oxide, J. Org. Chem., 60, 5434-5440.
11. [11] Janzen, E.G., Shetty R.V. and Kunanec, S.M. (1981) Spin trapping chemistry of 3,3,5,5-tetramethylpyrroline-N-oxide. An improved cyclic spin trap, Can. J. Chem., 59, 756-758.
12. [12] Janzen, E.G., Jandrisits, L., Shetty, R.V., Haire, D.L. and Hilborn, J.W. (1989) Synthesis and purification of 5,5-dimethyl-1-pyrroline N-oxide for biological applications. Chem. Biol. Interact., 70 (1,2), 167-172.
13. [13] Kaur, H., Leung, K.H.W. and Perkins M.J. (1981) A water-soluble, nitroso-aromatic spin-trap, J. Chem. Soc., Chem. Commun. 3, 142-143.
14. [14] Janzen, E.G., Dudley, R.L. and Shetty, R.V. (1979) Synthesis and electron spin resonance chemistry of nitronyl labels for spin trapping. α-Phenyl-N-[5-(5-methyl-2,2-diaikyl-1,3-dioxanyl)]nitrones and α-(N-alkylpyridinium)-N-tert-butyl)nitrones, J. Am. Chem. Soc., 101, 243.
15. [15] Janzen, E.G., Poyer, J.L., Schaefer, C.F., Downs, P.E. and DuBose, C.M. (1995) Biological spin trapping II, Toxicity of nitrone spin traps: Dose-ranging in the rat, J. Biochem. Biophys. Methods, 30, 239-247.