Regulatable production of mature insulin from a hepatocyte cell line: Insulin production is up-regulated by cAMP and glucocorticoids, and down-regulated by insulin

FEBS Letters

Volumn 399, Issue 1-2, 1996, Pages 37-42

  Lu, Danhong ^a   Hoshino, Hideki ^a   Takeuchi, Toshiyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Gene therapy; H4IIE; Insulin production; PEPCK promoter; Proinsulin processing

Indexed keywords

CYCLIC AMP; DEXAMETHASONE; INSULIN; ISOBUTYLMETHYLXANTHINE; RETINOIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; GENE CONSTRUCT; HEPATOMA CELL; INSULIN RELEASE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CYCLIC AMP; DEXAMETHASONE; DOWN-REGULATION; INSULIN; LIVER; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROMOTER REGIONS (GENETICS); RATS; RNA, MESSENGER; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0030577364     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01275-6     Document Type: Article

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