Degradation kinetics of ifosfamide in aqueous solution

International Journal of Pharmaceutics

Volumn 139, Issue 1-2, 1996, Pages 249-253

  Muñoz, Montserrat ^a   Bonjoch, Josep ^a   Prat, Josefina ^a   Pujol, Montserrat ^a   Girona, Victoria ^a   De Bolós, Jordi ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Chemical stability; Degradation kinetics; Ifosfamide

Indexed keywords

BUFFER; IFOSFAMIDE;

AQUEOUS SOLUTION; ARTICLE; DRUG DEGRADATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIC STRENGTH; KINETICS; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

EID: 0030576588     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04629-7     Document Type: Article

References (11)

1. Brade, W.P., Herdrich, K. and Varini, M., Ifosfamide pharmacology: safety and therapeutic potential. Cancer Treat. Res., 12 (1985) 1-47.
2. Brock, N., The oxazophosphorines. Cancer Treat. Res., 10 (1983) 3-15.
3. de Bolós, J., Castillo, M., Gallardo, M., Girona, V. and Riera, A., Modelo práctico de tratamiento estadístico de los datos, en estudios de estabilidad por degradación isotérmica acelerada. Farmaco, 8 (1986) 255-266.
4. Elias, A., Antman, K. and Eder, J., High dose of ifosfamide with mesna uroprotection: phase I study. ASCO Proc., 8 (1989) 264.
5. Harned, H.S. and Harmer, W. J., The ionization constant of water and the dissociation of water in potassium chloride solutions from electromotive forces of cells without liquid function. J. Am. Chem. Soc., 55 (1953) 2194-2206.
6. Kaijser, G.P., Beijnen, J.H., Bult, A., Hogeboom, M.H. and Underberg, W.J.M., A systematic study on the chemical stability of ifosfamide. J. Pharm. Biomed. Anal., 9 (1992) 1061-1067.
7. Le Roux, C.H., Modro, A.M. and Modro, T. A., Decomposition of N-phosphorylated nitrogen mustards: a mechanistic investigation. J. Org. Chem., 60 (1995) 3832-3839.
8. Lind, M.J., Marginson, J.M., Cerny, T., Thatcher, N. and Wilkinson, P.M., Comparative pharmacokinetics and alkylating activity of fractionated intravenous and oral ifosfamide in patients with bronchogenic carcinoma. Cancer Res., 49 (1989) 743-747.
9. Marginon, J.M., Wilkinson, P.M., Cerny, T. and Thatcher, N.A., Simple quantitative HPLC assay for ifosfamide in biological fluids. Biomed. Chromatogr., 1 (1986) 101-103.
10. Muñoz, M., Girona, V., Pujol, M., Duran, S., Vicente, P. and Solé, L.A., Stability of ifosfamide in 0.9% sodium chloride solution or water for injection in a portable i.v. pump cassette. Am. J. Hosp. Pharm., 49 (1992) 1137-1139.
11. Zalupski, M. and Baker, L.H., Ifosfamide review. J. Natl. Cancer Inst., 80 (1988) 556-566.