Neuroprotective (+) 3S, 4S cannabinoids with modified 5'-side chain

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 13, 1996, Pages 1553-1558

  Pop, Emil ^a   Browne, Clinton E ^a   Nadler, Varda ^a   Biegon, Anat ^a   Brewster, Marcus E ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; DEXANABINOL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ARTICLE; BRAIN INJURY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HEART ARREST; NEUROPROTECTION; STEREOSPECIFICITY; STROKE; STRUCTURE ACTIVITY RELATION;

EID: 0030576322     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00272-7     Document Type: Article

References (20)

1. (1) (a) Devane, W.A.; Dysarz, F.A,III.; Johnson, M.R.; Melvin, L.S.; Howlett, A.C. Mol.Pharmacol. 1988, 36, 605.
2. (b) Devane, W.A.; Breuer, A.; Sheskin, T.; Jarbe, T.U.C.; Eisen, M.S.; Mechoulam, R. J .Med. Chem. 1992, 35, 2065. For a review on the cannabinoid receptor see Howlett, A.C.; Bidaut-Russell, M.; Devane, W.A.; Melvin, L.S.; Johnson, M.R.; Herkenham, M. Trends Neurosci. 1990, 13, 420.
3. (b) Devane, W.A.; Breuer, A.; Sheskin, T.; Jarbe, T.U.C.; Eisen, M.S.; Mechoulam, R. J .Med. Chem. 1992, 35, 2065. For a review on the cannabinoid receptor see Howlett, A.C.; Bidaut-Russell, M.; Devane, W.A.; Melvin, L.S.; Johnson, M.R.; Herkenham, M. Trends Neurosci. 1990, 13, 420.
4. (2) Munro, S.; Thomas, K. L.; Abu-Shaar, M. Nature (London) 1993, 365, 61.
5. (3) Mechoulam, R.; Lander, N.; Breuer, A.; Zahalka, J. Tetrahedron: Assymetry 1990, 1, 315.
6. (4) Mechoulam, R.; Devane, W.A.; Glaser, R. In Marijuana/cannabinoids: neurobiology and neurophysiology. Murphy, L; Bartke, A., Ed.; CRC: Boca Raton, 1992; pp 1-33.
7. (5) Feigenbaum, J. J.; Bergmann, F.; Richmond, S. A.; Mechoulam, R.; Nadler, V.; Kloog, Y.; Sokolovscy, M. Proc. Nat. Acad. Sc. U.S.A. 1989, 86, 9584.
8. (6) Eshhar, N.; Striem, S.; Kohen, R.; Tirosh, O.; Biegon, A. Eur .J. Pharmacol. 1995, 283, 19.
9. (7) Zeltser, R.; Seltzer, Z.; Eisen, A.; Feigenbaum, J. J.; Mechoulam, R. Pain 1991, 47, 95.
10. (8) Eshhar, N.; Striem, S.; Biegon, A. Neuro Repor, 1993, 5, 237.
11. (9) Nadler, V.; Mechoulam, R.; Sokolovsky, N. Brain Res. 1993, 622, 79.
12. (10) Nadler, V.; Mechoulam, R.; Sokolovsky, N. Neurosci. Let. 1993, 162, 43.
13. (11) Shohami, E.; Novikov, M.; Mechoulam, R. J .Neurotrauma 1993, 10, 109.
14. (12) Bar-Joseph, A.; Berkovitch, Y.; Adamchik, J.; Biegon, A. Molecular and Chemical Neuropathology 1994, 23, 125.
15. (13) Razdan, R.K. Pharm.Rev. 1986, 38, 75.
16. (14) Mechoulam, R.; Feigenbaum, J. J. Progr .med .Chem. 1987, 24, 159.
17. (15) Dominianni, S. J.; Ryan, C. W.; DeArmitt, C. W. J. Org. Chem. 1977, 42, 344.
18. (16) Mechoulam, R.; Breuer, A.; Jarbe, U. C.; Hiltunen, A. J.; Glaser, R. J. Med. Chem. 1990, 33, 1037.
19. (17) Munson, P. J.; Rodbard, D. Anal. Biochem. 1980, 107, 220.
20. (18) Pop, E.; Liu, Z. Z.; Brewster, M. E.; Barenholz, Y.; Korablyov, V.; Mechoulam, R.; Nadler, V.; Biegon, A. Pharm. Res. 1996, 13, 62.