Molecular analysis of the Huntington's disease gene in New Zealand

New Zealand Medical Journal

Volumn 109, Issue 1015, 1996, Pages 27-30

  Whitefield, Julie E ^a,b   Williams, Liam ^b   Snow, Karen ^c   Dixon, Joanne ^d   Winship, Ingrid ^e   Stapleton, Patricia M ^f   Faull, Richard M ^g   Love, Donald R ^b  

^a School of Biological Sciences

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

^d WELLINGTON HOSPITAL   (New Zealand)

^e UNIVERSITY OF AUCKLAND   (New Zealand)

^f DNA Diagnostics Ltd   (New Zealand)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC COUNSELING; GENETIC SCREENING; GENETICS; HUMAN; HUNTINGTON CHOREA; METHODOLOGY; NEW ZEALAND; POLYMERASE CHAIN REACTION; REPRODUCIBILITY; STANDARD; TIME; TRINUCLEOTIDE REPEAT;

DNA; GENETIC COUNSELING; GENETIC SCREENING; HUMANS; HUNTINGTON DISEASE; IN SITU HYBRIDIZATION, FLUORESCENCE; NEW ZEALAND; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TRINUCLEOTIDE REPEATS;

EID: 0030576024     PISSN: 00288446     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Wexler NS, Rose EA, Housman DE. Molecular approaches to hereditary diseases of the nervous system: Huntington's disease as a paradigm. Ann Rev Neurosci 1991; 14: 603-29.
2. Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on the Huntington's disease chromosomes. Cell 1993; 72: 971-83.
3. Kremer B, Goldberg P, Andrew SB, et al. A worldwide study of the Huntington's disease mutation. The sensitivity and specificity of measuring CAG repeats. N Engl J Med 1994; 330: 1401-6.
4. Rubinsztein DC, Leggo J, Barton DE, Ferguson-Smith MA. Site of (CCG) polymorphism in the HD gene. Nature Genet 1993; 5: 214-5.
5. Andrew SA, Goldberg YP, Theilmann J, Zeisler J, Hayden MR. A CCG repeat polymorphism adjacent to the CAG repeat in the Huntington disease gene: implications for diagnostic accuracy and predictive testing. Hum Mol Genet 1994; 3: 65-7.
6. Warner JP, Barron LH, Brock DJH. A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes. Mol Cell Probes 1993; 7: 235-9.
7. Daiger SP, Hoffman NS, Wildin RS, Su T-S. Multiple, independent restriction site polymorphisms in human DNA detected with a cDNA probe to argininosuccinate synthetase (AS). Am J Hum Genet 1984; 36: 736-49.
8. MacDonald MD, Barnes G, Srinidhi J, et al. Gametic but not somatic instability of CAG repeat length in Huntington's disease. J Med Genet 1993; 30: 982-6.
9. Rubinsztein DC, Barton DE, Davison BCC, Ferguson-Smith MA. Analysis of the Huntington gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington's disease and CAG repeat number. Hum Mol Genet 1993; 2: 1713-5.
10. Snell RG, MacMillan JC, Cheadle JP, et al. Relationsbip between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nature Genet 1993; 4: 393-7.
11. Gusella JF, MacDonald ME, Ambrose CM, Duyao MP. Molecular genetics of Huntington's disease. Arch Neurol 1993; 50: 1157-63.
12. International Huntington Association and the World Federation of Neurology Research Group on Huntington's Chorea. Guidelines for the molecular genetics predictive test in Huntington's disease. Neurology 1994; 44: 1533-6.
13. World Federation of Neurology Research Group on Huntington's disease. Ethical issues policy statement on Huntington's disease molecular genetics predictive test J Med Genet 1990; 27: 34-8.
14. MacLeod AD, Lintott CJ, Kendall NAS, Brown EF. Huntington's disease and predictive testing. NZ Med J 1994; 107: 30-1.
15. Barron. LH, Warner JP, Porteous M, et al. A study of the Huntington's disease associated trinucleotide repeat in the Scottish population. J Med Genet 1993; 30: 1003-7.
16. Duyao M, Ambrose C, Myers R, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet 1993; 4: 387-92.
17. Zulhlke C, Riese O, Bockel B, Lange H, Thies U. Mitotic stability and meiotic variability of the (CAG)n repeat in the Huntington disease gene. Hum Mol Genet 1993; 2: 2063-7.
18. Goldberg YP, Andrew SE, Theilmann J, et al. Familial predisposition to recurrent mutations causing Huntington disease: genetic risk to siblings of sporadic cases. J Med Genet 1993; 30: 987-90.
19. Goldberg YP, Kremer B, Andrew SE, et al. Molecular analysis of new mutations for Huntington's disease: intermediate alleles and sex of origin effects. Nature Genet 1993; 5: 174-9.
20. Teleniue H, Almqvist E, Kremer B, et al. Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in Huntington disease. Hum Mol Genet 1995; 4: 189-195.
21. Benjamin CM, Adam S, Wiggins S, et al. Proceed with care: direct predictive testing for Huntington disease. Am J Hum Genet 1994; 55: 606-17.