메뉴 건너뛰기




Volumn 52, Issue 9, 1996, Pages 1331-1337

Drug-induced glycosaminoglycan storage: Dose-dependent changes in the pattern of accumulated glycosaminoglycans in cultured bovine and human fibroblasts

(1)  Fischer, Jens a,b  

b NONE   (Germany)

Author keywords

dermatan sulfate; dicationic amphiphilic drugs; glycosaminoglycans; lysosomal storage; lysosomotropic agents; tilorone

Indexed keywords

2,6 BIS(2 DIETHYLAMINOETHOXY) 9,10 ANTHRAQUINONE; AMPHOPHILE; CATION; CHONDROITIN SULFATE; CL 90100; DERMATAN SULFATE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; IMMUNOMODULATING AGENT; RMI 10223; TILORONE; UNCLASSIFIED DRUG;

EID: 0030575947     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00387-5     Document Type: Article
Times cited : (9)

References (25)
  • 2
    • 0017683934 scopus 로고
    • Tilorone hydrochloride: The drug profile
    • 2. Chandra P and Wright GJ, Tilorone hydrochloride: the drug profile. Top Curr Chem 72: 125-148, 1977.
    • (1977) Top Curr Chem , vol.72 , pp. 125-148
    • Chandra, P.1    Wright, G.J.2
  • 4
    • 0019720487 scopus 로고
    • The biological activity of the synthetic polyanion, pyran copolymer (Diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: Clinical and laboratory effects of these agents as modulators of host resistance
    • 4. Regelson W, The biological activity of the synthetic polyanion, pyran copolymer (Diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance. Pharmac Ther 15: 1-44, 1981.
    • (1981) Pharmac Ther , vol.15 , pp. 1-44
    • Regelson, W.1
  • 5
    • 0024429757 scopus 로고
    • Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues
    • 5. Hein L and Lüllmann-Rauch R, Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues. Toxicology 58: 145-154, 1989.
    • (1989) Toxicology , vol.58 , pp. 145-154
    • Hein, L.1    Lüllmann-Rauch, R.2
  • 6
    • 0026734801 scopus 로고
    • Induction of mucopolysaccharidosis in rats by treatment with immunostimulatory acridine derivatives
    • 6. Grave S, Lüllmann H, Lüllmann-Rauch R, Osterkamp G and Prokopek M, Induction of mucopolysaccharidosis in rats by treatment with immunostimulatory acridine derivatives. Toxicol Appl Pharmacol 114: 215-224, 1992.
    • (1992) Toxicol Appl Pharmacol , vol.114 , pp. 215-224
    • Grave, S.1    Lüllmann, H.2    Lüllmann-Rauch, R.3    Osterkamp, G.4    Prokopek, M.5
  • 7
    • 0025949293 scopus 로고
    • The tilorone-induced mucopolysaccharidosis in rats
    • 7. Prokopek M, The tilorone-induced mucopolysaccharidosis in rats. Biochem Pharmacol 42: 2187-2191, 1991.
    • (1991) Biochem Pharmacol , vol.42 , pp. 2187-2191
    • Prokopek, M.1
  • 8
    • 0025322738 scopus 로고
    • Cultured corneal fibroblasts as a model system for the demonstration of drug-induced mucopolysaccaridosis
    • 8. Burmester J, Handrock K and Lüllmann-Rauch R, Cultured corneal fibroblasts as a model system for the demonstration of drug-induced mucopolysaccaridosis. Arch Toxicol 64: 291-298, 1990.
    • (1990) Arch Toxicol , vol.64 , pp. 291-298
    • Burmester, J.1    Handrock, K.2    Lüllmann-Rauch, R.3
  • 9
    • 0025774229 scopus 로고
    • Drug-induced lysosomal storage of sulfated glycosaminoglycans in cultured bovine and human fibroblasts
    • 9. Lüllmann-Rauch R and Ziegenhagen M, Drug-induced lysosomal storage of sulfated glycosaminoglycans in cultured bovine and human fibroblasts. Virchows Arch [Zellpathol] 60: 99-104, 1991.
    • (1991) Virchows Arch [Zellpathol] , vol.60 , pp. 99-104
    • Lüllmann-Rauch, R.1    Ziegenhagen, M.2
  • 10
    • 0027769329 scopus 로고
    • Drug-induced lysosomal storage of sulfated glycosaminoglycans. Studies on the underlying structure activity relationships
    • 10. Handrock K, Lüllmann-Rauch R and Vogt R, Drug-induced lysosomal storage of sulfated glycosaminoglycans. Studies on the underlying structure activity relationships. Toxicology 85: 199-213, 1993.
    • (1993) Toxicology , vol.85 , pp. 199-213
    • Handrock, K.1    Lüllmann-Rauch, R.2    Vogt, R.3
  • 11
    • 0026734799 scopus 로고
    • Lysosomal storage of sulfated glycosaminoglycans in cultured fibroblasts exposed to immunostimulatory acridine derivatives
    • 11. Handrock K, Laschke A, Lüllmann-Rauch R, Vogt RD and Ziegenhagen M, Lysosomal storage of sulfated glycosaminoglycans in cultured fibroblasts exposed to immunostimulatory acridine derivatives. Toxicol Appl Pharmacol 114: 204-214, 1992.
    • (1992) Toxicol Appl Pharmacol , vol.114 , pp. 204-214
    • Handrock, K.1    Laschke, A.2    Lüllmann-Rauch, R.3    Vogt, R.D.4    Ziegenhagen, M.5
  • 12
    • 0011993322 scopus 로고    scopus 로고
    • Degradation of free galactosaminoglycan chains is inhibited by two immunomodulatory compounds in cultured fibroblasts
    • 12. Fischer J, Degradation of free galactosaminoglycan chains is inhibited by two immunomodulatory compounds in cultured fibroblasts. Naunyn Schmiedebergs Arch Pharmacol 353, Supp R78, 1996.
    • (1996) Naunyn Schmiedebergs Arch Pharmacol , vol.353 , Issue.SUPPL. R78
    • Fischer, J.1
  • 13
    • 0028802752 scopus 로고
    • Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: Biochemical and physicochemical investigations
    • 13. Fischer J, Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: Biochemical and physicochemical investigations. Biochem J 312: 215-222, 1995.
    • (1995) Biochem J , vol.312 , pp. 215-222
    • Fischer, J.1
  • 15
    • 0028990047 scopus 로고
    • Tilorone-induced lysosomal storage of sulfated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion
    • 15. Lüllmann-Rauch R, Pods R and Von Witzendorff B, Tilorone-induced lysosomal storage of sulfated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion. Biochem Pharmacol 49: 1223-1233, 1995.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1223-1233
    • Lüllmann-Rauch, R.1    Pods, R.2    Von Witzendorff, B.3
  • 16
    • 0014374718 scopus 로고
    • Analytical and preparative separation of acidic glycosaminoglycans by electrophoresis in barium acetate
    • 16. Wessler E, Analytical and preparative separation of acidic glycosaminoglycans by electrophoresis in barium acetate. Anal Biochem 26: 439-444, 1968.
    • (1968) Anal Biochem , vol.26 , pp. 439-444
    • Wessler, E.1
  • 17
    • 0018425749 scopus 로고
    • Beeinflussung der glycosaminoglycansynthese von kultivierten stromazellen aus rindercorneae durch variation dur kulturbedingungen
    • 17. Bleckmann H and Kresse H, Beeinflussung der Glycosaminoglycansynthese von kultivierten Stromazellen aus Rindercorneae durch Variation dur Kulturbedingungen. Albrecht v Graefes Arch klin exp Ophthal 210: 291-300, 1979.
    • (1979) Albrecht V Graefes Arch Klin Exp Ophthal , vol.210 , pp. 291-300
    • Bleckmann, H.1    Kresse, H.2
  • 18
    • 0018883907 scopus 로고
    • Glycosaminoglycan metabolism of cultured cornea cells derived from bovine and human stroma and from bovine epithelium
    • 18. Bleckmann H and Kresse H, Glycosaminoglycan metabolism of cultured cornea cells derived from bovine and human stroma and from bovine epithelium. Exp Eye Res 30: 469-479, 1980.
    • (1980) Exp Eye Res , vol.30 , pp. 469-479
    • Bleckmann, H.1    Kresse, H.2
  • 19
    • 0015816317 scopus 로고
    • The occurrence of a wide variety of dermatan sulfate-chondroitin sulfate copolymers in fibrous cartilage
    • 19. Habuchi H, Yamagata T, Iwata H and Suzuki S, The occurrence of a wide variety of dermatan sulfate-chondroitin sulfate copolymers in fibrous cartilage. J Biol Chem 248: 6019-6028, 1973.
    • (1973) J Biol Chem , vol.248 , pp. 6019-6028
    • Habuchi, H.1    Yamagata, T.2    Iwata, H.3    Suzuki, S.4
  • 20
    • 0017132903 scopus 로고
    • The synthesis of glycosaminoglycans by cultures of rabbit corneal endothelial and stroma cells
    • 20. Yue BY, Baum JL and Silbert JE, The synthesis of glycosaminoglycans by cultures of rabbit corneal endothelial and stroma cells. Biochem J 158: 567-573, 1976.
    • (1976) Biochem J , vol.158 , pp. 567-573
    • Yue, B.Y.1    Baum, J.L.2    Silbert, J.E.3
  • 21
    • 0016635617 scopus 로고
    • Fractionation of proteoglycans from bovine corneal stroma
    • 21. Axelsson I and Heinegard D, Fractionation of proteoglycans from bovine corneal stroma. Biochem J 145: 491-500, 1975.
    • (1975) Biochem J , vol.145 , pp. 491-500
    • Axelsson, I.1    Heinegard, D.2
  • 22
    • 0026519599 scopus 로고
    • A biochemical analysis of human peridontal tissue proteoglycans
    • 22. Larjava H, Häkkinen L, Rahemtulla F, A biochemical analysis of human peridontal tissue proteoglycans. Biochem J 284: 267-274, 1992.
    • (1992) Biochem J , vol.284 , pp. 267-274
    • Larjava, H.1    Häkkinen, L.2    Rahemtulla, F.3
  • 23
    • 0020973226 scopus 로고
    • Inhibitors of lysosomal function
    • 23. Seglen PO, Inhibitors of lysosomal function. Meth Enzymol 96: 737-764, 1983.
    • (1983) Meth Enzymol , vol.96 , pp. 737-764
    • Seglen, P.O.1
  • 24
    • 0019307389 scopus 로고
    • Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling
    • 24. Gonzalez-Noriega A, Grubb JH, Talkad V and Sly WS, Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling. J Cell Biol 85: 839-853, 1980.
    • (1980) J Cell Biol , vol.85 , pp. 839-853
    • Gonzalez-Noriega, A.1    Grubb, J.H.2    Talkad, V.3    Sly, W.S.4
  • 25
    • 0023792145 scopus 로고
    • The potential role of lysosomes in tissue distribution of weak bases
    • 25. MacIntyre AC and Cutler DJ, The potential role of lysosomes in tissue distribution of weak bases. Biopharm Drug Dispos 9: 513-526, 1988.
    • (1988) Biopharm Drug Dispos , vol.9 , pp. 513-526
    • MacIntyre, A.C.1    Cutler, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.