Accurate reading of morphogen concentrations by nuclear receptors: A formal model of complex transduction pathways

Journal of Theoretical Biology

Volumn 183, Issue 1, 1996, Pages 95-104

  Kerszberg, Michel ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ARTICLE; DEVELOPMENTAL GENETICS; GENETIC TRANSCRIPTION; MORPHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0030574251     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0205     Document Type: Article

References (47)

1. ARCIONI, L., SIMEONE, A., GUAZZI, S., ZAPPAVIGNA, V., BONCINELLI, E. & MAVILIO, F. (1992). The upstream region of the human homeobox gene Hox3D is a target for regulation by retinoic acid and Hox homeoproteins. EMBO J. 11, 265-277.
2. AVEROF, M. & AKAM, M. (1995). Hox genes and the diversification 1 of insect and crustacean body plans. Nature 376, 420-423.
3. BOURGUET, W., RUFF, M., CHAMBON, P., GRONEMEYER, H. & MORAS, D. (1995). Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375, 377-382.
4. CARROLL, S. B. (1995). Homeotic genes and the evolution of arthropods and chordates. Nature 376, 479-485.
5. DE THÉ, H., VIVANCO-RUIZ, M. M., TIOLLAIS, P., STUNNENBERG, H. & DEJEAN, A. (1990). Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature 343, 177-180.
6. DOLLE, P., FRAULOB, V., KASTNER, P. & CHAMBON, P. (1994). Developmental expression of murine retinoic X receptor (RXR) genes. Mech. Dev. 45, 91-104.
7. DRIEVER, W. & NÜSSLEIN-VOLHARD, C. (1988). The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 54, 95-104.
8. EICHELE, G. & THALLER, C. (1987). Characterization of concentration gradients of a morphogenetically active retinoic acid in the chick limb bud. J. Cell. Biol. 105, 1917-1923.
9. GIERER, A. (1981). Generation of biological patterns and form: some physical, mathematical and logical aspects. Prog. Biophys. Molec. Biol. 37, 1-47.
10. GURDON, J. B., LEMAIRE, P. & KATO, K. (1993). Community effects and related phenomena in development. Cell 75, 831-834.
11. JIANG, J. & LEVINE, M. (1993). Binding affinities and cooperative interactions with bHLH. Activators delimit threshold responses to the dorsal gradient morphogen. Cell 72, 741-752.
12. KASTNER, P., MARK, M. & CHAMBON, P. (1995). Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83, 859-869.
13. KELLER, A. D. (1995). Model genetic circuits encoding autoregulatory transcription factors. J. theor. Biol. 172, 169-185.
14. KERSZBERG, M. & CHANGEUX, J.-P. (1994a). A model for reading morphogenetic gradients: autocatalysis and competition at the gene level. Proc. Natl. Acad. Sci. U.S.A. 91, 5823-5827.
15. KERSZBERG, M. & CHANGEUX, J.-P. (1994b). Partners make patterns in morphogenesis. Curr. Biol. 4, 1046-1047.
16. KUROKAWA, R., DIRENZO, J., BOEHM, M., SUGARMAN, J., GLOSS, B., ROSENFELD, M. G. et al. (1994). Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371, 528-531.
17. KUROKAWA, R., Yu, V. C., NÄÄR, A., KYAKUMOTO, S., HAN, Z., SILVERMAN, S. et al. (1993). Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genes Dev. 7, 1423-1435.
18. LANGSTON, A. & GUDAS, L. (1992). Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6. Mech. Dev. 38, 217-227.
19. LANGSTON, A. & GUDAS, L. (1994). Retinoic acid and homeobox gene regulation. Curr. Opin. Genet. Dev. 4, 550-555.
20. LAUDET, V. & STEHELIN, D. (1992). Flexible friends. Curr. Biol. 2, 293-295.
21. LAUDET, V., HÄNNI, C., COLL, J., CATZEFLIS, F. & STÉHELIN, D. (1992). Evolution of the nuclear receptor gene superfamily. EMBO J. 11, 1003-1013.
22. LEWIS, J., SLACK, J. & WOLPERT, L. (1977). Thresholds in development. J. theor. Biol. 65, 579-590.
23. MANGELSDORF, D. J. & EVANS, R. M. (1995). The RXR heterodimers and orphan receptors. Cell 83, 841-850.
24. MANGELSDORF, D. J., UMESONO, K., KLIEWER, S. A., BORGMEYER, U., ONG, E. S. & EVANS, R. M. (1991). A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell 65, 555-561.
25. MARSHALL, H., STUDER, M., PÖPPERL, H., APARICIO, S., KUROIWA, A., BRENNER, S. & KRUMLAUF, R. (1994). A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature 370, 567-571.
26. MEINHARDT, H. (1994). Biological pattern formation: new observations provide support for theoretical predictions. BioEssays 16, 627-632.
27. MEINHARDT, H. (1978). Space-dependent cell determination under the control of a morphogen gradient. J. theor. Biol. 74, 307-321.
28. 2 null mutant mice appear normal. Dev. Biol. 166, 246-258.
29. MORRIS-KAY, G. (1993). Retinoic acid and craniofacial development: molecules and morphogenesis. BioEssays 15, 9-15.
30. PAPAGEORGIOU, S. & ALMIRANTIS, Y. (1992). Diffusion or autocatalysis of retinoic acid cannot explain pattern formation in the chick wing bud. Developmental Dynamics 194, 282-288.
31. PATEL, N. H. (1994). Developmental evaluation: insights from studies of insect segmentation. Science 266, 581-590.
32. PÖPPERL, H., BIENZ, M., STUDER, M., CHAN, S.-K., APARICIO, S., BRENNER, S., MANN, R. & KRUMLAUF, R. (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon esd/pbx. Cell 81, 1031-1042.
33. QUIRING, R., WALLDORF, U., KLOTER, U. & GEHRIG, W. J. (1994). Homology of the eyeless gene of Drosophila to the small eye gene in mice and Aniridia in humans. Science 265, 785-789.
34. RAGSDALE JR., C. W. & BROCKES, J. P. (1991). Retinoids and their targets in vertebrate development. Curr. Op. Cell Biol. 3, 928-934.
35. RIDDLE, R., JOHNSON, R., LAUFER, E. & TABIN, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
36. SLACK, J. M. W., HOLLAND, P. W. H. & GRAHAM, C. F. (1993). The zootype and the phylotypic stage. Nature 361, 490-492.
37. STUDER, M., PÖPPERL, H., MARSHALL, H., KUROIWA, A. & KRUMLAUF, R. (1994). Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science 265, 1728-1732.
38. THOMAS, R. & D'ARI, R. (1990). Biological Feedback. CRC Press.
39. TURING, A. M. (1952). The chemical basis of morphogenesis. Phil. Trans. Roy. Soc. 237, 37-72.
40. VIVIANO, C. M., HORTON, C. E., MADEN, M. & BROCKES, J. P. (1996). Synthesis and release of 9-cis retinoic acid by the urodele wound epidermis. Development 121, in press.
41. WARREN, R. W., NAGY, L., SELEGUE, J., GATES, J., & CARROLL, S. (1994). Evolution of Homeotic Gene regulation and Function in Flies and Butterflies. Nature 372, 458-461.
42. WILSON, P. A. & MELTON, D. (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol. 4, 676-686.
43. WOLPERT, L. (1969). Positional information and the spatial pattern of cellular differentiation. J. theor. Biol. 25, 1-47.
44. Yu, V. C., DELSERT, C., ANDERSEN, B., HOLLOWAY, J. M., DEVARY, O. V., NÄÄR, A. M., KIM, S. Y., BOUTIN, J.-M., GLASS, C. K. & ROSENFELD, M. G. (1991). RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67, 1251-1266.
45. ZECHEL, C., SHEN, X.-Q., CHAMBON, P. & GRONEMEYER, H. (1994a). Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR4 and DR5 elements. EMBO J. 13, 1414-1424.
46. ZECHEL, C., SHEN, X.-Q., CHEN, J.-Y., CHEN, Z.-P., CHEMBON, P. & GRONEMEYER, H. (1994b). The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J. 13, 1425-1433.
47. ZUKER, C. S. (1994). On the evolution of eyes: would you like it simple or compound? Science 265, 742-743.