Nonlinear enzyme kinetics can lead to high metabolic flux control coefficients: Implications for the evolution of dominance

Journal of Theoretical Biology

Volumn 182, Issue 3, 1996, Pages 299-302

  Grossniklaus, Ueli ^a,b   Madhusudhan, M S ^a   Nanjundiah, Vidyanand ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION RESPONSE; DOMINANT INHERITANCE; ENZYME KINETICS; ENZYME SUBSTRATE; EVOLUTION; METABOLIC REGULATION; NONLINEAR SYSTEM; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0030574068     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0167     Document Type: Article

References (6)

1. CORNISH-BOWDEN, A. (1987). Diminance is not inevitable. J. theor. Biol. 125, 333-338.
2. GOLDBETER, A. & SEGEL, L. A. (1977). Unified mechanism for relay and oscillation of cyclic AMP in Dictyostelium discoideum. Proc. Natl. Acad. Sci. USA 74, 1543-1547
3. HEINRICH, R. & RAPOPORT, T. A. (1974). A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 42, 89-95.
4. KACSER, H. & BURNS, J. A. (1973). The control of flux. In: Rate Control of Biological Processes (Davies, D. D., ed.) pp. 65-104. Cambridge: Cambridge University Press.
5. KACSER, H. & BURNS, J. A. (1981). The molecular basis of dominance. Genetics 97, 639-666.
6. NANJUNDIAH, V. (1994). Why are most mutations recessive? J. Genetics 72, 85-97.